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TISSUE PRIMARY DATA KIDNEY Show tissue menu
ADIPOSE TISSUE ADRENAL GLAND AMYGDALA APPENDIX BASAL GANGLIA BLOOD VESSEL BONE MARROW BREAST BRONCHUS CEREBELLUM CEREBRAL CORTEX CERVIX CHOROID PLEXUS COLON
DUODENUM ENDOMETRIUM EPIDIDYMIS ESOPHAGUS FALLOPIAN TUBE GALLBLADDER HEART MUSCLE HIPPOCAMPAL FORMATION HYPOTHALAMUS KIDNEY LIVER LUNG LYMPH NODE MIDBRAIN
NASOPHARYNX ORAL MUCOSA OVARY PANCREAS PARATHYROID GLAND PITUITARY GLAND PLACENTA PROSTATE RECTUM RETINA SALIVARY GLAND SEMINAL VESICLE SKELETAL MUSCLE SKIN
SMALL INTESTINE SMOOTH MUSCLE SOFT TISSUE SPINAL CORD SPLEEN STOMACH TESTIS THYMUS THYROID GLAND TONGUE TONSIL URINARY BLADDER VAGINA
ANTIBODIES
AND
VALIDATION
Dictionary
Kidney
Tissue proteome
Kidney
Tissue methods
KIDNEY - Expression summary
Protein expression
Kidneyi

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

h
m
l
n
Bowman's capsule: Not detected
Cells in glomeruli: Not detected
Collecting ducts: Not detected
Distal tubules: Medium
Proximal tubules (cell body): Medium
Proximal tubules (microvilli): Not detected
Protein profiling
Multiplex tissuei

A summary of the protein localization in the current human tissue based on multiplex immunohistochemistry profiling in selected tissues is shown for genes where this analysis has been performed.

Cytoplasmic staining in proximal tubules. Additional staining in distal tubules and podocytes.

RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

Scroll down to view mRNA expression data in more detail.

Consensus:583.6 nTPM
HPA:140.6 nTPM
GTEx:583.6 nTPM
FANTOM5:198.1 Scaled Tags Per Million
KIDNEY - SINGLE CELL RNA EXPRESSION
Explore single cell type data

KIDNEY - Multiplex stainingi

Antibody localization in the annotated cell types/states/structures of the current human tissue is reported as main/additional locations, percent overlap between the antibody and cell type/state/structure-specific markers, and, when applicable also subcellular localization. The scores are based on multiplex immunohistochemistry profiling in selected tissues.

Main locations are characterized by a high overlap between the antibody and the cell type/state-specific marker combined with strong antibody signal intensity, while additional locations are characterized by lower overlap and weaker antibody signal intensity.

The antibody of interest is reported in green, while cell types/states/structures are reported in various other colors, and DAPI (marks nucleus) is reported in blue. Colors can be toggled on and off by clicking on the name of the cell type/state of interest, “Antibody” or “DAPI”. To toggle between the different tissue samples, click on the miniature images at the right bottom corner of the main image. The miniature images appear upon hovering the mouse over that area.

- Antibody HPA075879
Main location Proximal tubules
Additional location Distal tubules
Podocytes
No antibody overlap
Antibody overlap>75%
LocationCytoplasm
Plasma membrane
Antibody overlap50%-25%
LocationCytoplasm
Antibody overlap>75%
LocationCytoplasm
No antibody overlap

KIDNEY - Antibody stainingi

Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

Antibody HPA075879
Bowman's capsule Not detected
Cells in glomeruli Not detected
Collecting ducts Not detected
Distal tubules Medium
Proximal tubules (cell body) Medium
Proximal tubules (microvilli) Not detected



KIDNEY - HPA RNA-seqi

The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

Average nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

140.6
overview
Female, age 58
Kidney sample 55
nTPM: 239.4
Cell types%
Cells in tubules:
60

Cells in glomeruli:
20

Fibroblasts:
5

Other cell types:
15

overview
Female, age 67
Kidney sample 56
nTPM: 278.5
Cell types%
Cells in tubules:
70

Cells in glomeruli:
15

Fibroblasts:
10

Other cell types:
5

overview
Female, age 55
Kidney sample 57
nTPM: 100.2
Cell types%
Cells in tubules:
80

Cells in glomeruli:
10

Fibroblasts:
5

Other cell types:
5

overview
Male, age 46
Kidney sample 58
nTPM: 306.4
Cell types%
Cells in tubules:
60

Cells in glomeruli:
25

Fibroblasts:
5

Other cell types:
10

overview
Female, age 57
Kidney sample 358
nTPM: 42.2
Cell types%
Cells in tubules:
60

Cells in glomeruli:
10

Fibroblasts:
10

Other cell types:
20

overview
Male, age 78
Kidney sample 377
nTPM: 45
Cell types%
Cells in tubules:
65

Cells in glomeruli:
10

Fibroblasts:
5

Other cell types:
20

overview
Male, age 73
Kidney sample 380
nTPM: 156.5
Cell types%
Cells in tubules:
60

Cells in glomeruli:
10

Fibroblasts:
10

Other cell types:
20

overview
Female, age 59
Kidney sample 394
nTPM: 65
Cell types%
Cells in tubules:
65

Cells in glomeruli:
10

Fibroblasts:
10

Other cell types:
15

overview
Female, age 48
Kidney sample 414
nTPM: 32.6
Cell types%
Cells in tubules:
60

Cells in glomeruli:
5

Fibroblasts:
10

Other cell types:
25


KIDNEY - GTEx RNA-seqi

RNA-Seq data generated by the Genotype-Tissue Expression (GTEx) project from human tissues is reported as mean nTPM. More information can be found on the GTEx portal.

Distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

583.6
GTEx sample id Sample description nTPM
Kidney - Cortex
Average nTPM: 583.6
Samples: 104

Max nTPM: 1993.7
Min nTPM: 30.8
Std nTPM: 390.1
Median nTPM: 497.2
GTEX-1HCVE-2126-SM-HL9UO 50-59 years, male 1993.7
GTEX-T5JC-1526-SM-4DM68 20-29 years, male 1366.2
GTEX-16Z82-2826-SM-HAUZZ 60-69 years, male 1341.4
GTEX-1E2YA-1626-SM-7MGXS 50-59 years, male 1336.1
GTEX-QDVN-1726-SM-HL9TO 50-59 years, male 1316.8
GTEX-13OW6-1826-SM-5N9F9 50-59 years, male 1278.2
GTEX-REY6-1826-SM-EAZAT 60-69 years, male 1269.3
GTEX-14JG1-2326-SM-HAUZ5 40-49 years, male 1262.4
GTEX-14C5O-2026-SM-5YYB1 60-69 years, male 1213.1
GTEX-1BAJH-1826-SM-731DA 70-79 years, male 1178.7
GTEX-13NYB-1726-SM-5N9G2 40-49 years, male 1174.4
GTEX-Y5V5-1226-SM-EYYVP 60-69 years, female 1160.7
GTEX-1H3NZ-2126-SM-9WPQ6 60-69 years, male 1092.2
GTEX-14E6D-2526-SM-5YYA9 50-59 years, male 1077.2
GTEX-1NV8Z-2226-SM-EXOJ2 60-69 years, male 1070.6
GTEX-1JJ6O-2526-SM-AHZ3J 60-69 years, male 1047.8
GTEX-QDT8-1726-SM-EYYV6 30-39 years, female 1039.0
GTEX-T6MN-1826-SM-EXOHN 50-59 years, male 1015.5
GTEX-15DYW-2026-SM-6AJBD 60-69 years, female 968.0
GTEX-1RQEC-2426-SM-F2I1J 60-69 years, male 962.1
GTEX-1KWVE-0826-SM-CXZKO 30-39 years, male 949.8
GTEX-1GMR3-2426-SM-7MXV2 40-49 years, male 926.9
GTEX-17HHY-2326-SM-7KFSR 50-59 years, male 916.6
GTEX-1HBPI-2026-SM-CE6RZ 50-59 years, male 911.6
GTEX-P4QS-1126-SM-3NMD5 60-69 years, male 885.1
GTEX-14PJ2-1826-SM-HL9UB 50-59 years, male 881.0
GTEX-17F96-1926-SM-7MGWY 70-79 years, male 833.9
GTEX-NFK9-1826-SM-HL9T3 40-49 years, male 830.3
GTEX-1JMLX-1526-SM-AHZ3N 50-59 years, male 787.3
GTEX-1GN1U-2126-SM-AHZ4J 50-59 years, female 771.5
GTEX-WL46-1926-SM-GNIN6 50-59 years, male 763.8
GTEX-1C6VQ-2326-SM-7IGN1 50-59 years, male 721.1
GTEX-11OF3-1326-SM-5N9FJ 60-69 years, male 698.9
GTEX-15CHQ-2126-SM-6871M 60-69 years, male 692.0
GTEX-O5YV-1226-SM-EV795 60-69 years, female 690.6
GTEX-1ICLY-2026-SM-GA913 50-59 years, male 688.8
GTEX-13FHP-2126-SM-GIN8J 50-59 years, male 681.4
GTEX-Y5V6-2026-SM-5IFHO 60-69 years, male 678.7
GTEX-1QP6S-1526-SM-EXUSG 40-49 years, male 672.4
GTEX-1GF9W-1326-SM-7P8PX 60-69 years, male 655.5
GTEX-1O9I2-1926-SM-F2TBQ 50-59 years, male 629.3
GTEX-1JMQJ-1726-SM-E9U4V 50-59 years, male 628.7
GTEX-14C39-2126-SM-664OH 40-49 years, male 621.0
GTEX-1IKK5-0926-SM-A9G2U 60-69 years, male 595.6
GTEX-1497J-0826-SM-5NQAJ 60-69 years, male 594.8
GTEX-1QAET-2126-SM-F2TBS 50-59 years, male 590.1
GTEX-16XZZ-2226-SM-HAV34 60-69 years, male 589.7
GTEX-1HB9E-1826-SM-D4P33 50-59 years, male 584.5
GTEX-S33H-1426-SM-EZ6L7 30-39 years, male 515.9
GTEX-1R9PO-1626-SM-E6CPT 60-69 years, female 513.7
GTEX-145MN-0326-SM-5QGQI 30-39 years, male 506.0
GTEX-1HCU7-1826-SM-A9G2A 50-59 years, male 498.5
GTEX-15DCD-1926-SM-HAV33 70-79 years, female 495.9
GTEX-1GF9V-1926-SM-9JGHE 60-69 years, male 488.0
GTEX-1JMPZ-1226-SM-ARU8Y 30-39 years, male 483.1
GTEX-1F48J-2226-SM-7MXTN 50-59 years, female 452.9
GTEX-ZC5H-1726-SM-5HL7X 40-49 years, female 434.9
GTEX-ZDXO-0226-SM-4WKH7 60-69 years, male 431.8
GTEX-1JJE9-1026-SM-HL9TH 70-79 years, male 429.9
GTEX-1GTWX-1826-SM-9QEHG 60-69 years, male 424.9
GTEX-13RTJ-2226-SM-5S2Q1 60-69 years, male 419.0
GTEX-11GS4-2326-SM-5A5KS 60-69 years, male 416.6
GTEX-1117F-2126-SM-GIN9G 60-69 years, female 415.8
GTEX-13O3O-1726-SM-GJ3RL 60-69 years, female 415.0
GTEX-XPVG-0526-SM-4B65N 50-59 years, male 404.0
GTEX-1LG7Y-2726-SM-D5OVW 50-59 years, male 392.2
GTEX-1I1GP-1926-SM-CNNQU 50-59 years, male 382.6
GTEX-1A8FM-2026-SM-7P8RN 50-59 years, female 375.5
GTEX-16MT8-1926-SM-7EPGL 60-69 years, female 356.7
GTEX-17F97-1926-SM-7IGM4 50-59 years, male 345.9
GTEX-1MUQO-2526-SM-E9TJN 60-69 years, male 338.1
GTEX-147F4-2626-SM-5Q5CS 50-59 years, male 334.4
GTEX-1EKGG-2226-SM-7IGOA 60-69 years, male 319.7
GTEX-1IL2V-1826-SM-ARU7R 70-79 years, male 304.1
GTEX-1N2EF-1426-SM-EXUSH 60-69 years, male 300.8
GTEX-ZE9C-1426-SM-4WKGM 60-69 years, male 300.0
GTEX-1N2DW-1826-SM-EAZ54 50-59 years, male 296.0
GTEX-11TTK-1926-SM-5PNW8 60-69 years, female 294.6
GTEX-1PWST-2226-SM-EVR3G 70-79 years, male 279.7
GTEX-ZYFG-1626-SM-5GZYY 60-69 years, female 277.1
GTEX-ZLFU-0926-SM-5P9F8 40-49 years, male 258.9
GTEX-ZVZP-0926-SM-5GIDB 50-59 years, male 210.7
GTEX-1AX8Z-2326-SM-731CR 60-69 years, male 204.9
GTEX-1K9T9-1826-SM-CXZK2 50-59 years, female 204.9
GTEX-1J1OQ-1426-SM-AHZ3P 40-49 years, female 200.0
GTEX-ZXG5-2026-SM-HAUZV 60-69 years, male 198.5
GTEX-1JMQK-1926-SM-CJI3B 60-69 years, male 195.5
GTEX-13O1R-2526-SM-5N9FW 60-69 years, male 194.0
GTEX-1CB4J-1926-SM-7MGX8 60-69 years, male 191.0
GTEX-1399S-0526-SM-5IJG8 30-39 years, female 189.5
GTEX-1A3MW-2226-SM-73KUX 60-69 years, female 184.4
GTEX-12WSG-0826-SM-5EQ5A 50-59 years, female 172.8
GTEX-13OVI-1126-SM-5KLZF 60-69 years, female 131.8
GTEX-13OVL-1826-SM-5KLZR 50-59 years, male 112.2
GTEX-RN64-1626-SM-48FD7 50-59 years, male 106.7
GTEX-1H3VY-1926-SM-9JGHJ 50-59 years, male 105.7
GTEX-QLQW-1626-SM-CMKFE 30-39 years, male 101.7
GTEX-W5X1-1626-SM-H7OGO 40-49 years, female 93.6
GTEX-16XZY-1026-SM-HAV39 70-79 years, male 87.6
GTEX-1OJC4-2326-SM-DTXA5 50-59 years, female 70.5
GTEX-ZYT6-2226-SM-5GIC9 30-39 years, male 68.5
GTEX-12696-0926-SM-5FQTV 60-69 years, male 60.6
GTEX-13112-2126-SM-5GCO4 50-59 years, male 43.5
GTEX-1LH75-1326-SM-F2I1R 50-59 years, female 30.8
Show allShow less
Kidney - Medulla
Average nTPM: 249.0
Samples: 11

Max nTPM: 988.1
Min nTPM: 20.3
Std nTPM: 335.5
Median nTPM: 63.9
GTEX-P4QS-1226-SM-HPAG8 60-69 years, male 988.1
GTEX-N7MS-1526-SM-HAUZP 60-69 years, male 797.9
GTEX-RU72-1926-SM-EAZ3F 50-59 years, female 524.4
GTEX-TKQ2-0626-SM-EZ6LB 50-59 years, male 126.6
GTEX-T6MN-1926-SM-GOQYD 50-59 years, male 86.9
GTEX-QEG4-1526-SM-GPRWK 30-39 years, male 63.9
GTEX-SIU8-1926-SM-H7OG4 50-59 years, male 45.8
GTEX-T5JC-1626-SM-EZ6KW 20-29 years, male 29.6
GTEX-S33H-1526-SM-GQ1CB 30-39 years, male 29.4
GTEX-R55E-2026-SM-EZ6L1 20-29 years, male 26.1
GTEX-QEG5-2026-SM-H6Q6I 20-29 years, male 20.3
Show allShow less

KIDNEY - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

198.1
FANTOM5 sample id Sample description Scaled Tags Per Million
Kidney
Scaled Tags Per Million: 198.1
FF:10017-101C8 60,62,63 years, female 198.1

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