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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
p13.1
Chromosome location (bp)
38937920 - 39074399
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the mechanistic target of rapamycin complex 2 (mTORC2), which transduces signals from growth factors to pathways involved in proliferation, cytoskeletal organization, lipogenesis and anabolic output 1,2,3,4,5,6,7,8. In response to growth factors, mTORC2 phosphorylates and activates AGC protein kinase family members, including AKT (AKT1, AKT2 and AKT3), PKC (PRKCA, PRKCB and PRKCE) and SGK1 9,10,11. In contrast to mTORC1, mTORC2 is nutrient-insensitive 12,13. Within the mTORC2 complex, RICTOR probably acts as a molecular adapter 14,15,16. RICTOR is responsible for the FKBP12-rapamycin-insensitivity of mTORC2 17. mTORC2 plays a critical role in AKT1 activation by mediating phosphorylation of different sites depending on the context, such as 'Thr-450', 'Ser-473', 'Ser-477' or 'Thr-479', facilitating the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDPK1/PDK1 which is a prerequisite for full activation 18,19,20,21. mTORC2 catalyzes the phosphorylation of SGK1 at 'Ser-422' and of PRKCA on 'Ser-657' (By similarity). The mTORC2 complex also phosphorylates various proteins involved in insulin signaling, such as FBXW8 and IGF2BP1 (By similarity). mTORC2 acts upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors 22. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin 23....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q6R327 [Direct mapping] Rapamycin-insensitive companion of mTOR
Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Essential proteins Protein evidence (Ezkurdia et al 2014)
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GO:0005515[protein binding] GO:0005829[cytosol] GO:0007010[cytoskeleton organization] GO:0007154[cell communication] GO:0009792[embryo development ending in birth or egg hatching] GO:0016310[phosphorylation] GO:0018105[peptidyl-serine phosphorylation] GO:0019901[protein kinase binding] GO:0030307[positive regulation of cell growth] GO:0031532[actin cytoskeleton reorganization] GO:0031669[cellular response to nutrient levels] GO:0031929[TOR signaling] GO:0031932[TORC2 complex] GO:0032008[positive regulation of TOR signaling] GO:0032956[regulation of actin cytoskeleton organization] GO:0038203[TORC2 signaling] GO:0043066[negative regulation of apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0051897[positive regulation of protein kinase B signaling] GO:0060090[molecular adaptor activity]
Q6R327 [Direct mapping] Rapamycin-insensitive companion of mTOR
Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001932[regulation of protein phosphorylation] GO:0005515[protein binding] GO:0005829[cytosol] GO:0007010[cytoskeleton organization] GO:0007154[cell communication] GO:0009792[embryo development ending in birth or egg hatching] GO:0010468[regulation of gene expression] GO:0016310[phosphorylation] GO:0018105[peptidyl-serine phosphorylation] GO:0019901[protein kinase binding] GO:0030307[positive regulation of cell growth] GO:0030838[positive regulation of actin filament polymerization] GO:0031532[actin cytoskeleton reorganization] GO:0031669[cellular response to nutrient levels] GO:0031929[TOR signaling] GO:0031932[TORC2 complex] GO:0032008[positive regulation of TOR signaling] GO:0032956[regulation of actin cytoskeleton organization] GO:0033135[regulation of peptidyl-serine phosphorylation] GO:0038203[TORC2 signaling] GO:0043022[ribosome binding] GO:0043066[negative regulation of apoptotic process] GO:0043087[regulation of GTPase activity] GO:0043539[protein serine/threonine kinase activator activity] GO:0050727[regulation of inflammatory response] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0051716[cellular response to stimulus] GO:0051896[regulation of protein kinase B signaling] GO:0051897[positive regulation of protein kinase B signaling] GO:0060090[molecular adaptor activity] GO:2000114[regulation of establishment of cell polarity]
The Human Protein Atlas project is funded
