Protein interactions - MKRN3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MKRN3
Synonyms	D15S9, MGC88288, RNF63, ZFP127, ZNF127
Gene descriptionⁱ Full gene name according to HGNC.	Makorin ring finger protein 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocyte progenitor cells - Development & myelination (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Astrocytes, Bergmann glia, Choroid plexus epithelial cells, Ependymal cells, Oligodendrocyte progenitor cells, Oligodendrocytes)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Oligodendrocytes - Myelination (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Brain, Retina)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Plasma membrane, Cytosol In addition localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	15
Cytoband	q11.2
Chromosome location (bp)	23565674 - 23630075
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9
Ensembl	ENSG00000179455 (version 109)
Entrez gene	7681
HGNC	HGNC:7114
UniProt	Q13064
GeneCards	MKRN3

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Oligodendrocytes - Myelination

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
LARP4B	5	17	24	10	12
MDM4	11	23	28	1	2
UBE2D1	34	40	123	0	0
ZNF688	2	28	4	1	0

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Number of interactions:

118

View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ADRA2C	0	10	0	0	0
ANTKMT	0	10	0	0	0
APEX2	0	3	2	1	0
AQP1	1	106	2	0	0
ARID5A	2	96	2	0	0
ARMC5	0	8	5	0	0
ATOSB	1	51	1	0	0
ATXN3	3	74	64	1	0
AVPI1	0	29	0	0	4
BATF2	1	10	1	0	0
BCL2L11	7	15	22	0	0
BEX2	1	68	4	0	0
BLZF1	4	85	7	3	3
BPIFA1	0	38	1	0	9
CCDC120	8	93	13	0	5
CCDC185	0	34	0	0	2
CDCA4	7	20	13	0	9
CEP70	17	197	18	0	0
CERCAM	0	28	1	0	36
CRACR2A	0	33	1	0	0
CYSRT1	0	397	1	0	0
DDIT4L	1	169	1	0	0
ECM1	0	27	0	0	0
ECSIT	9	14	23	0	31
EFEMP1	2	27	13	0	0
ENKD1	5	161	5	0	0
ERCC1	5	9	15	2	0
FAM110A	1	41	1	1	0
FAM124B	2	24	2	0	0
FARS2	1	58	2	0	2
GADD45GIP1	15	90	22	4	73
GEM	0	88	2	0	0
GOLGA6A	1	37	1	0	0
GRAP2	10	41	18	0	5
HEXB	1	25	2	4	2
HGS	33	178	84	8	0
HSF2BP	3	224	5	0	0
IKZF3	4	131	22	0	0
INO80B	9	49	19	0	6
KANK2	5	153	7	3	0
KLF1	1	14	6	0	0
KLHL38	0	72	0	0	0
KRT34	5	201	5	0	0
KRT75	10	103	17	0	0
KRT86	3	38	3	0	0
KRTAP19-2	0	33	0	0	0
KRTAP19-6	0	50	0	0	0
KRTAP19-7	0	72	0	0	0
KRTAP21-2	0	25	0	0	0
KRTAP6-2	0	137	0	0	0
KRTAP7-1	0	28	0	0	0
KRTAP8-1	0	76	0	0	0
LAGE3	7	20	11	0	25
MAGED1	7	80	25	2	0
MCCD1	0	21	0	0	0
MDM4	11	23	28	1	2
MEOX1	1	78	2	0	0
MORN3	0	58	0	0	1
MRPL38	13	17	27	0	35
MRPS6	5	4	10	1	30
MYOZ2	1	10	1	0	0
NABP1	1	9	2	0	0
NDUFB7	3	27	17	0	7
NME4	4	44	13	0	1
ODAD4	0	7	0	0	0
ODF3B	0	8	0	0	0
PEX26	2	28	5	0	0
PKN1	7	59	20	3	0
POLR1C	34	88	46	47	0
POMC	0	13	1	0	0
PRKAA2	8	79	30	0	3
PRPF31	11	118	57	0	0
PRR35	0	58	0	0	0
PSMA1	37	145	78	24	0
PSMB1	43	84	63	43	20
PTH1R	2	9	4	0	1
PTK6	4	24	13	0	0
RASD1	0	24	2	0	0
RBM41	2	23	2	0	0
RBPMS2	1	40	3	0	0
RIBC1	1	21	1	0	22
RSPO4	0	12	1	0	0
RTP5	0	49	0	0	0
SCNM1	2	148	3	3	0
SF1	9	14	37	3	0
SFN	59	126	102	1	0
SLPI	0	12	1	0	0
SMARCD1	17	105	51	16	0
SMYD3	0	7	5	0	2
SNRPC	54	49	65	203	31
SORBS3	4	88	7	0	0
STH	0	16	1	0	0
STMN3	0	18	2	1	4
STN1	2	16	3	0	10
SYNGAP1	6	24	18	0	0
TARDBP	16	141	74	7	0
TASOR2	1	36	3	0	3
TCEA2	3	88	4	0	0
TCHP	6	40	16	0	1
TCL1B	0	11	0	0	3
TENT5B	2	57	2	0	3
TFAP2A	3	7	25	4	1
TFIP11	22	180	39	10	11
TRAF2	53	240	125	2	0
TSGA10IP	0	83	0	0	0
TSPAN4	0	30	0	0	0
TXNDC11	0	7	1	0	0
UBE2D1	34	40	123	0	0
UBE2K	18	61	35	3	0
UQCC2	2	10	2	1	2
USHBP1	8	162	12	0	0
VPS9D1	1	22	1	2	0
ZBTB42	0	38	1	0	4
ZIM2	0	26	0	0	6
ZNF414	0	43	0	0	23
ZNF587	0	102	0	0	0
ZNF688	2	28	4	1	0
ZNF835	0	54	0	0	0
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ANKRD11	0	0	15	2	2
LARP4B	5	17	24	10	12
MBD3	8	14	52	11	0
MDM4	11	23	28	1	2
MOV10	10	9	78	5	21
PABPC1	20	25	144	0	0
PABPC3	0	3	3	0	3
PABPC4	11	3	70	17	0
RNF10	6	17	16	0	0
UBE2D1	34	40	123	0	0
UPF1	33	17	89	52	0
ZNF688	2	28	4	1	0
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Subcell location

Predicted location

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Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
GSPT2	4	3	4	1	18
LARP4B	5	17	24	10	12

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene MKRN3 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Golgi apparatus	524	320	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MKRN3-201	Q13064		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Show all	507 aa 55.6 kDa	No	0
MKRN3-202		H3BPL3	Metabolic proteins Predicted intracellular proteins Human disease related genes	182 aa 19.6 kDa	No	0
MKRN3-203		Q6NSB6	Metabolic proteins Predicted intracellular proteins Human disease related genes	105 aa 10.5 kDa	No	0
MKRN3-206		A0A3B3IRN4	Metabolic proteins Predicted intracellular proteins Human disease related genes	38 aa 4 kDa	No	0
MKRN3-207		A0A3B3IRU9	Metabolic proteins Predicted intracellular proteins Human disease related genes	161 aa 17.4 kDa	No	0
MKRN3-208		A0A7I2YQ72	Metabolic proteins Predicted intracellular proteins Human disease related genes	330 aa 34.6 kDa	No	0
MKRN3-209		A0A7I2V4D6	Metabolic proteins Predicted intracellular proteins Human disease related genes	123 aa 12.4 kDa	No	0
MKRN3-211		A0A7I2V2Q0	Metabolic proteins Predicted intracellular proteins Human disease related genes	320 aa 33.6 kDa	No	0
MKRN3-212		A0A7I2V6H1	Metabolic proteins Predicted intracellular proteins Human disease related genes	102 aa 10.2 kDa	No	0
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