Protein interactions - SETD2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SETD2
Synonyms	FLJ23184, HIF-1, HYPB, KIAA1732, KMT3A
Gene descriptionⁱ Full gene name according to HGNC.	SET domain containing 2, histone lysine methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Essential proteins Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neutrophils - Innate immune cellular maintenance (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nuclear speckles In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	3
Cytoband	p21.31
Chromosome location (bp)	47016428 - 47164113
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9
Ensembl	ENSG00000181555 (version 109)
Entrez gene	29072
HGNC	HGNC:18420
UniProt	Q9BYW2
GeneCards	SETD2

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Transcription

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BioGrid

OpenCell

BioPlex

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
SMAD3	28	52	128	0	2

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
SMAD3	28	52	128	0	2

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AURKA	11	18	116	0	2
CLK2	15	45	40	2	0
H3C1	26	53	300	0	14
HTT	36	666	56	0	0
IWS1	1	0	7	10	0
POLR2A	10	0	186	11	0
RHOBTB1	1	3	27	0	2
RPA1	7	10	420	1	1
SMAD3	28	52	128	0	2
SPOP	9	29	86	0	2
TLE3	1	1	39	0	0
TP53	123	166	704	5	0
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CPSF6	36	8	62	212	0
HNRNPL	33	4	118	70	1
RBM39	147	25	243	217	0
SF3A1	60	9	97	120	13
SNRPA	71	41	94	246	4
SNRPB	79	28	111	217	0
SNRPC	54	49	65	203	31
SSRP1	61	9	107	333	28
TOP1	49	6	101	259	1

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
HSPB8	9	15	12	0	51
SAP18	9	8	75	0	16

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene SETD2 is associated with 7 reactions in 1 different subsystems, and present in the compartments: Cytosol, Nucleus. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Lysine metabolism	Cytosol, Nucleus, Endoplasmic reticulum, Peroxisome, Mitochondria	49	63	7

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SETD2-202	Q9BYW2		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	2564 aa 287.6 kDa	No	0
SETD2-203		C9JG86	Metabolic proteins Predicted intracellular proteins Cancer-related genes Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1340 aa 149.3 kDa	No	0
SETD2-209		A0A1W2PPX9	Metabolic proteins Predicted intracellular proteins Cancer-related genes Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	2520 aa 282.6 kDa	No	0
SETD2-210		A0A8I5KV15	Metabolic proteins Predicted intracellular proteins Cancer-related genes Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	2486 aa 278.7 kDa	No	0
SETD2-212		A0A8I5KNR2	Metabolic proteins Predicted intracellular proteins Cancer-related genes Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1352 aa 151.7 kDa	No	0
SETD2-216		A0A8I5KSB8	Metabolic proteins Predicted intracellular proteins Cancer-related genes Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1470 aa 165.2 kDa	No	0
SETD2-219		A0A8I5KPS6	Metabolic proteins Predicted intracellular proteins Cancer-related genes Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1349 aa 152.4 kDa	No	0
SETD2-221		A0A8I5QJW6	Metabolic proteins Predicted intracellular proteins Cancer-related genes Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	916 aa 102.7 kDa	No	0
SETD2-222		A0A8I5KYR1	Metabolic proteins Predicted intracellular proteins Cancer-related genes Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	1163 aa 131.3 kDa	No	0
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