Protein interactions - SRPK3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SRPK3
Synonyms	MSSK1, STK23
Gene descriptionⁱ Full gene name according to HGNC.	SRSF protein kinase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal myocytes - Muscle structure & formation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Breast lactating cells, Cardiomyocytes, Corticotrophs, Myonuclei, Salivary ionocytes, Thymic myoid cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal muscle - Striated muscle contraction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Skeletal muscle, Tongue)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153776412 - 153785732
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8
Ensembl	ENSG00000184343 (version 109)
Entrez gene	26576
HGNC	HGNC:11402
UniProt	Q9UPE1
GeneCards	SRPK3

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Skeletal muscle - Striated muscle contraction

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Cell type

Category

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Pathway

Consensus

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BioGrid

OpenCell

BioPlex

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Cell type specificity

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
SRPK1	30	30	69	20	6

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Predicted location

Cell type specificity

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Number of interactions:

View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
SRPK1	30	30	69	20	6

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Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
BRIX1	14	5	35	15	21
CCDC137	4	1	8	4	51
CCDC86	1	0	13	5	3
DDX24	18	3	68	0	49
DDX54	2	1	27	8	0
EBNA1BP2	8	5	46	11	4
FTSJ3	19	5	50	14	45
GNL2	10	1	35	17	50
KRR1	16	2	42	1	86
LLPH	2	1	7	9	2
LUC7L	5	7	22	0	0
NOC3L	6	0	25	1	37
NOP2	4	7	61	6	0
PDCD11	1	1	19	3	35
PHF5A	12	4	27	4	14
PRPF4B	24	5	36	73	24
PUM3	5	0	31	3	43
RBM28	11	2	33	10	30
RBM34	7	0	27	6	44
RBM39	147	25	243	217	0
RPF2	3	2	20	2	39
RRP15	3	0	13	6	22
RRP1B	5	11	30	13	0
RRS1	6	4	39	2	37
RSL1D1	12	6	52	20	16
SNRNP70	16	11	168	11	0
SNRPA	71	41	94	246	4
SNRPC	54	49	65	203	31
SNU13	5	4	27	17	6
SON	5	1	19	14	0
SRPK1	30	30	69	20	6
STAU1	32	13	371	39	0
SURF6	7	4	18	0	175
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene SRPK3 is associated with 6 reactions in 2 different subsystems, and present in the compartments: Cytosol, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	5
Bile acid biosynthesis	Peroxisome, Endoplasmic reticulum, Cytosol, Mitochondria, Extracellular	94	171	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SRPK3-201		A8MPP7	Metabolic proteins Predicted intracellular proteins	492 aa 55.4 kDa	No	0
SRPK3-202	Q9UPE1		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt	567 aa 62 kDa	No	0
SRPK3-203	Q9UPE1		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt	566 aa 61.9 kDa	No	0
SRPK3-204		A8MPY5	Metabolic proteins Predicted intracellular proteins	534 aa 59.1 kDa	No	0
SRPK3-205	Q9UPE1		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt	533 aa 59 kDa	No	0
SRPK3-206		H7C1T4	Metabolic proteins Predicted intracellular proteins	205 aa 22.3 kDa	No	0
SRPK3-207		H7C2I2	Metabolic proteins Predicted intracellular proteins	129 aa 14.7 kDa	No	0
SRPK3-208		E7ETV6	Metabolic proteins Predicted intracellular proteins	634 aa 69.2 kDa	No	0
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