Protein interactions - POLR3C - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLR3C
Synonyms	C82, RPC3, RPC62
Gene descriptionⁱ Full gene name according to HGNC.	RNA polymerase III subunit C
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Essential proteins Metabolic proteins RNA polymerase related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Elongating spermatids - Spermiogenesis: Elongation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Early spermatids, Late spermatids)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Testis - Nuclear processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	1
Cytoband	q21.1
Chromosome location (bp)	145824053 - 145844402
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5
Ensembl	ENSG00000186141 (version 109)
Entrez gene	10623
HGNC	HGNC:30076
UniProt	Q9BUI4
GeneCards	POLR3C

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Testis - Nuclear processes

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Cluster

Cell type

Category

Cluster

Pathway

Consensus

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Interaction:

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CRCP	14	3	16	17	0
KPNA1	32	15	77	30	4
KPNA2	31	37	85	43	7
POLR1C	34	88	46	47	0
POLR1D	29	6	34	64	0
POLR2E	68	42	88	109	11
POLR2F	37	1	50	62	28
POLR2H	35	1	54	51	2
POLR2L	31	16	48	22	30
POLR3A	24	4	37	26	15
POLR3B	25	1	33	36	11
POLR3D	21	1	23	21	17
POLR3E	22	1	30	30	16
POLR3F	19	13	19	25	7
POLR3G	12	3	12	18	10
POLR3GL	13	8	13	17	12
POLR3H	16	2	17	21	0
POLR3K	16	3	20	12	30
TBP	29	18	70	41	21
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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ANKRD23	0	17	1	0	0
CEP44	5	40	13	0	0
COIL	16	37	33	6	17
ENKD1	5	161	5	0	0
GOLGA2	21	350	58	11	0
HAUS1	14	83	20	1	2
INCA1	9	205	10	0	0
KATNBL1	2	31	2	0	4
KIAA0408	1	24	1	0	0
KLHL2	4	23	13	0	0
KPNA1	32	15	77	30	4
KPNA3	15	33	33	28	3
KPNA5	3	17	9	0	3
KPNA6	16	19	35	22	4
KRT75	10	103	17	0	0
LZTS1	1	73	3	2	0
PAX6	2	79	17	0	0
PICK1	10	276	36	0	9
PNMA5	1	53	1	0	0
POLR2E	68	42	88	109	11
POLR3F	19	13	19	25	7
POLR3G	12	3	12	18	10
POLR3GL	13	8	13	17	12
POU6F2	0	103	0	0	0
RBBP8NL	0	7	0	0	0
ROCK1	3	9	12	1	8
ROPN1	0	37	1	0	0
TRAF2	53	240	125	2	0
TRIM27	20	235	63	0	0
VRTN	0	9	0	0	0
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Predicted location

Cell type specificity

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CRCP	14	3	16	17	0
GTF3C4	3	3	17	3	5
KPNA1	32	15	77	30	4
KPNA2	31	37	85	43	7
POLR1C	34	88	46	47	0
POLR1D	29	6	34	64	0
POLR2E	68	42	88	109	11
POLR2F	37	1	50	62	28
POLR2H	35	1	54	51	2
POLR2L	31	16	48	22	30
POLR3A	24	4	37	26	15
POLR3B	25	1	33	36	11
POLR3D	21	1	23	21	17
POLR3E	22	1	30	30	16
POLR3F	19	13	19	25	7
POLR3G	12	3	12	18	10
POLR3GL	13	8	13	17	12
POLR3H	16	2	17	21	0
POLR3K	16	3	20	12	30
TBP	29	18	70	41	21
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Subcell location

Predicted location

Cell type specificity

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CRCP	14	3	16	17	0
CSNK2A1	99	67	249	184	22
CSNK2A2	56	8	149	232	22
KPNA2	31	37	85	43	7
POLR1C	34	88	46	47	0
POLR1D	29	6	34	64	0
POLR2E	68	42	88	109	11
POLR2F	37	1	50	62	28
POLR2H	35	1	54	51	2
POLR2K	37	2	42	103	0
POLR3A	24	4	37	26	15
POLR3B	25	1	33	36	11
POLR3D	21	1	23	21	17
POLR3E	22	1	30	30	16
POLR3F	19	13	19	25	7
POLR3G	12	3	12	18	10
POLR3GL	13	8	13	17	12
POLR3H	16	2	17	21	0
TBP	29	18	70	41	21
TRMT1L	2	1	8	34	1
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Subcell location

Predicted location

Cell type specificity

Protein class

In same cell type

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
MAF1	6	5	6	11	6
POLR2F	37	1	50	62	28
POLR2L	31	16	48	22	30
POLR3D	21	1	23	21	17
POLR3E	22	1	30	30	16
POLR3GL	13	8	13	17	12
POLR3K	16	3	20	12	30

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene POLR3C is associated with 2 reactions in 1 different subsystems, and present in the compartments: Cytosol, Nucleus. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Nucleotide metabolism	Cytosol, Lysosome, Mitochondria, Nucleus, Extracellular, Golgi apparatus	151	80	2

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR3C-201	Q9BUI4		Metabolic proteins Predicted intracellular proteins RNA polymerase related proteins Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	534 aa 60.6 kDa	No	0
POLR3C-202		E9PHH9	Metabolic proteins Predicted intracellular proteins RNA polymerase related proteins Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	411 aa 46.2 kDa	No	0
POLR3C-207			Metabolic proteins Predicted intracellular proteins RNA polymerase related proteins Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	534 aa 60.6 kDa	No	0
POLR3C-212			Metabolic proteins Predicted intracellular proteins RNA polymerase related proteins Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	450 aa 51.2 kDa	No	0
POLR3C-217			Metabolic proteins Predicted intracellular proteins RNA polymerase related proteins Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	323 aa 36.3 kDa	No	0
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