The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Subsets of leukocytes were distinctly stained. The majority of normal tissues displayed moderate to strong cytoplasmic and/or membranous positivity. Cells in gastrointestinal tract, CNS, islets of Langerhans, cells in seminiferus ducts and hepatocytes of liver were weakly stained or negative.
Strong nuclear immunoreactivity was observed in alveolar cells and in subset of lymphoid cells. Macrophages displayed additional cytoplasmic staining. Remaining normal tissues were in general negative.
Strong cytoplasmic and nuclear positivity was showed in lung, urothelial cells, fibroblasts, Langerhans cells, chondrocytes, hematopoietic cells and lymphoid cells. Cells in endometrial stroma, endothelial cells, peripheral nerve, adipocytes and decidual cells were moderately stained. Remaining normal tissues were negative.
Strong cytoplasmic and nuclear positivity was observed in fibroblats, cells in lung, subsets of leukocytes and placental decidual cells. Urothelium and cervical glands showed moderate staining. Remaining normal cells were weakly stained or negative.
Lymphoid cells showed moderate cytoplasmic immunoreactivity. Decidual cells and urothelium showed moderate cytoplasmic and nuclear positivity. Other normal cell types were negative.
Pneumocytes, fibroblasts and cells in red pulp of spleen showed strong nuclear and cytoplasmic staining. Decidual cells, stomach and urothelial cells displayed moderate immunoreactivity. Infiltrating lymphoid cells showed moderate cytoplasmic and nuclear staining. Cardiac myocytes showed moderate cytoplasmic staining. Lung macrophages exhibited moderate membranous and cytoplasmic staining. Remaining normal cell types were mainly negative.