The Cancer resource - Explore the expression profiles of human cancers

Cancer methods

The Cancer Resource provides an integrated view of gene and protein expression across human cancer types, combining transcriptomics, mass spectrometry (MS) and immunohistochemistry (IHC). The resource includes mRNA expression data from 21 cancer types, MS-based proteomics data covering 25 cancer types, and IHC staining profiles for 20 cancer types. The MS data is derived from two independed data sources and include both tumor and adjecent non-tumor tissue, enabling exploration of cancer-associated changes in protein abundance.

Expression specificity across cancer types is assessed using both RNA and MS data, allowing genes and proteins with elevated expression in particular cancer types to be identified. The molecular data are complemented by millions of in-house generated immunohistochemically stained tissue images, as well as Kaplan–Meier survival analysis showing associations between gene expression and patient survival, validated in independent patient cohorts for 10 cancer types. More information about the specific content and the generation and analysis of the data in the resource can be found in the Methods Summary.

Learn about:

• RNA and protein expression across different cancer types
• genes and proteins enriched in particular cancer types
• differences in protein abundance between tumor and adjacent non-tumor tissue
• genes with expression associated with patient survival