General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Human gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Reconciled phylogenetic tree illustrating the inferred evolutionary relationships of genes within the orthogroup based on canonical peptide sequences. Each leaf represents a gene (identified by its species code and Ensembl gene ID), while the branching structure reflects their inferred phylogeny. An orthogroup may contain multiple genes from the same species due to lineage-specific gene duplication events. Branch lengths represent estimated sequence divergence, with shorter distances indicating more closely related sequences. The asterisk (*) indicates that the orthology relationship between that gene and the currently viewed human gene is annotated as high-confidence in Ensembl.
The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.
The tissue data for RNA expression obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM project are reported as Scaled Tags Per Million. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.
0.54
Pig tissue specificityi
The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.
The tissue data for RNA expression obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM project are reported as Scaled Tags Per Million. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.
0.48
Rat tissue specificityi
The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.
The tissue data for RNA expression obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM project are reported as Scaled Tags Per Million. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.
0.60
Mouse tissue specificityi
The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.
The tissue data for RNA expression obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM project are reported as Scaled Tags Per Million. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.
0.61
Macaque tissue specificityi
The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.
The tissue data for RNA expression obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM project are reported as Scaled Tags Per Million. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.
Conservation category is a categoric annotation that intends to capture the available pairwise species overlap annotations into one metric. The categories range from: Complete, Partial and Minimal Conservation for conserved genes; and Tissue elevation shift, human specific tissue elevated, Non-Human tissue elevated, Human specific detected and Human not detected for non conserved genes.
Human-specific tissue elevated
Species overlapi
Species overlap is a categoric annotation reflecting a species pairwise tissue specificity overlap to the human. It is computed at across matching tissues. The categories range from: Complete, Partial and Minimal Overlap for overlapping genes, and Human specific tissue elevated, Non-human tissue elevated and inconsistent detection for non overlapping genes.
Macaque
Human-specific tissue elevated
Mouse
Human-specific tissue elevated
Rat
Human-specific tissue elevated
Pig
Human-specific tissue elevated
Cosine similarityi
Cosine similarity is applied as a measure of how two species share their relative gene expression proportions across matching tissues. It is a numerical indicator of relative expression overlap, where the values range from 0 to 1, where 0 indicates low similarity and 1 indicates high similarity.
RNA expression overview shows RNA-data from two different sources: Internally generated Human Protein Atlas RNA-seq data and RNA-seq data from the Genotype-Tissue Expression GTEx project, as well as the consensus dataset which is based on a combination of both sources. Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
Human dataseti
The consensus dataset consists of normalized expression (nTPM) levels for 51 tissue types, created by combining the HPA and GTEx transcriptomics datasets using the internal normalization pipeline . Color-coding is based on tissue groups, each consisting of tissues with functional features in common. To access sample data, click on tissue name or bar.
Read more about how the datasets were combined into consensus normalized expression levels here.
A summary of RNA categories for human tissues, cell lines and cancer tissues. Categories for RNA specificity include tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Categories for RNA distribution include detected in single, detected in some, detected in many, detected in all and not detected.
Human tissue RNA category is based on the consensus dataset, which is a combination of RNA data from human tissues from three sources: HPA, GTEX and FANTOM5. Cell line RNA category is based on RNA data from cell lines. More information can be found about the normalization and classification of these datasets.
Antibodies used for this assay. Click on an antibody for more information.
Organ
Expression
Alphabetical
Rat dataseti
Normalized RNA expression levels (nTPM) shown for the 13 brain regions. Color coding is based on brain region and the bar shows the highest expression among the subregions included. To access sample data, click on region name or bar.
Read more about normalized expression levels here.
Organ
Expression
Alphabetical
Pig dataseti
Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected.
Organ
Expression
Alphabetical
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The Human Protein Atlas project is funded
Macaque
Mouse
Rat
Pig
