General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes FDA approved drug targets Housekeeping proteins Human disease related genes Metabolic proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q23.3
Chromosome location (bp)
128083766 - 128189677
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane 1,2,3,4,5,6,7,8. Plays a vital role in the regulation of ionic balance and cell volume 9,10,11,12....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Ion transport, Potassium transport, Sodium transport, Symport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Chloride, Potassium, Sodium
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P55011 [Direct mapping] Solute carrier family 12 member 2
Q53ZR1 [Target identity:100%; Query identity:100%] Bumetanide-sensitive Na-K-Cl cotransporter; Solute carrier family 12 (Sodium/potassium/chloride transporters), member 2, isoform CRA_b
Metabolic proteins Housekeeping proteins Housekeeping in single cell types Housekeeping in tissues Housekeeping in single nuclei brain Housekeeping in cell lines Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) deepTMHMM predicted membrane proteins
Show all
GO:0005515[protein binding] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006821[chloride transport] GO:0006883[cellular sodium ion homeostasis] GO:0006884[cell volume homeostasis] GO:0006972[hyperosmotic response] GO:0007214[gamma-aminobutyric acid signaling pathway] GO:0007568[aging] GO:0008511[sodium:potassium:chloride symporter activity] GO:0008519[ammonium transmembrane transporter activity] GO:0009925[basal plasma membrane] GO:0010818[T cell chemotaxis] GO:0015079[potassium ion transmembrane transporter activity] GO:0015293[symporter activity] GO:0015377[cation:chloride symporter activity] GO:0015379[potassium:chloride symporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016328[lateral plasma membrane] GO:0019901[protein kinase binding] GO:0022857[transmembrane transporter activity] GO:0030007[cellular potassium ion homeostasis] GO:0030321[transepithelial chloride transport] GO:0030644[cellular chloride ion homeostasis] GO:0030659[cytoplasmic vesicle membrane] GO:0031253[cell projection membrane] GO:0035633[maintenance of blood-brain barrier] GO:0035725[sodium ion transmembrane transport] GO:0035865[cellular response to potassium ion] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0044297[cell body] GO:0044298[cell body membrane] GO:0045795[positive regulation of cell volume] GO:0046873[metal ion transmembrane transporter activity] GO:0051087[chaperone binding] GO:0051879[Hsp90 protein binding] GO:0055064[chloride ion homeostasis] GO:0055075[potassium ion homeostasis] GO:0055078[sodium ion homeostasis] GO:0055085[transmembrane transport] GO:0061044[negative regulation of vascular wound healing] GO:0070062[extracellular exosome] GO:0070634[transepithelial ammonium transport] GO:0071805[potassium ion transmembrane transport] GO:0071944[cell periphery] GO:0072488[ammonium transmembrane transport] GO:0098658[inorganic anion import across plasma membrane] GO:0098659[inorganic cation import across plasma membrane] GO:0098719[sodium ion import across plasma membrane] GO:0150003[regulation of spontaneous synaptic transmission] GO:0150104[transport across blood-brain barrier] GO:1902476[chloride transmembrane transport] GO:1903561[extracellular vesicle] GO:1904450[positive regulation of aspartate secretion] GO:1904464[regulation of matrix metallopeptidase secretion] GO:1990573[potassium ion import across plasma membrane] GO:1990869[cellular response to chemokine]
P55011 [Direct mapping] Solute carrier family 12 member 2
Metabolic proteins Housekeeping proteins Housekeeping in single cell types Housekeeping in tissues Housekeeping in single nuclei brain Housekeeping in cell lines Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Nervous system diseases Ear disease Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) deepTMHMM predicted membrane proteins
Show all
GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0006811[ion transport] GO:0006813[potassium ion transport] GO:0006814[sodium ion transport] GO:0006883[cellular sodium ion homeostasis] GO:0006884[cell volume homeostasis] GO:0007214[gamma-aminobutyric acid signaling pathway] GO:0008511[sodium:potassium:chloride symporter activity] GO:0008519[ammonium transmembrane transporter activity] GO:0009925[basal plasma membrane] GO:0010818[T cell chemotaxis] GO:0015079[potassium ion transmembrane transporter activity] GO:0015293[symporter activity] GO:0015377[cation:chloride symporter activity] GO:0015379[potassium:chloride symporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016323[basolateral plasma membrane] GO:0016324[apical plasma membrane] GO:0016328[lateral plasma membrane] GO:0019901[protein kinase binding] GO:0022857[transmembrane transporter activity] GO:0030007[cellular potassium ion homeostasis] GO:0030321[transepithelial chloride transport] GO:0030644[cellular chloride ion homeostasis] GO:0030659[cytoplasmic vesicle membrane] GO:0031253[cell projection membrane] GO:0035633[maintenance of blood-brain barrier] GO:0035725[sodium ion transmembrane transport] GO:0035865[cellular response to potassium ion] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0044297[cell body] GO:0044298[cell body membrane] GO:0046873[metal ion transmembrane transporter activity] GO:0051087[chaperone binding] GO:0051879[Hsp90 protein binding] GO:0055064[chloride ion homeostasis] GO:0055075[potassium ion homeostasis] GO:0055078[sodium ion homeostasis] GO:0055085[transmembrane transport] GO:0061044[negative regulation of vascular wound healing] GO:0070062[extracellular exosome] GO:0070634[transepithelial ammonium transport] GO:0071944[cell periphery] GO:0072488[ammonium transmembrane transport] GO:0098658[inorganic anion import across plasma membrane] GO:0098659[inorganic cation import across plasma membrane] GO:0098719[sodium ion import across plasma membrane] GO:0150003[regulation of spontaneous synaptic transmission] GO:0150104[transport across blood-brain barrier] GO:1902476[chloride transmembrane transport] GO:1903561[extracellular vesicle] GO:1904450[positive regulation of aspartate secretion] GO:1904464[regulation of matrix metallopeptidase secretion] GO:1990573[potassium ion import across plasma membrane] GO:1990869[cellular response to chemokine]
We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.