Protein interactions - PKM - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PKM
Synonyms	OIP3, PK3, PKM2, THBP1
Gene descriptionⁱ Full gene name according to HGNC.	Pyruvate kinase M1/2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Essential proteins Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Elongating spermatids - Sperm cell metabolism & fertilization (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Esophageal apical cells, Esophageal basal cells, Esophageal suprabasal cells, Extravillous trophoblasts, Late spermatids, Platelets)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Skeletal muscle, Tongue)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol In addition localized to the Vesicles, Principal piece
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	15
Cytoband	q23
Chromosome location (bp)	72199029 - 72231819
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13
Ensembl	ENSG00000067225 (version 109)
Entrez gene	5315
HGNC	HGNC:9021
UniProt	P14618
GeneCards	PKM

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Non-commercial use only, subject to AlphaFold3 Output Terms of Use

Interaction:

Color scheme:

Confidence

Antibodies

Interactor

Show surface:

Off

Autorotate:

Off

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ARRB1	26	35	59	0	0
ARRB2	21	25	68	0	0
CTNNB1	47	85	285	13	13

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ARAF	19	16	65	11	4
ARRB1	26	35	59	0	0
ARRB2	21	25	68	0	0
CTNNB1	47	85	285	13	13
DAPK1	8	9	27	0	1
FGFR3	4	191	23	0	0
HTT	36	666	56	0	0
RYBP	15	44	42	0	23
SPRED1	3	309	3	0	0
TINF2	4	48	10	2	0
UBQLN1	29	214	63	5	0
Show allShow less

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACE2	10	13	278	0	0
AGR2	3	64	227	0	2
ANLN	1	0	568	2	0
ARHGAP24	0	1	12	0	0
ARRB1	26	35	59	0	0
ARRB2	21	25	68	0	0
CCNF	4	4	624	0	1
CDC25A	6	7	29	2	0
CDKN1A	29	50	93	0	19
CFTR	34	103	236	0	0
CTNNB1	47	85	285	13	13
CUL3	40	45	771	2	0
DDX39B	24	15	110	44	0
DUX4	3	3	39	0	0
EGLN3	5	17	27	0	7
ENO1	5	6	78	5	1
ENO3	1	1	8	1	0
EP300	27	34	372	4	1
EPM2A	2	2	11	0	3
EZH2	16	16	236	7	0
FGFR1	12	13	68	0	0
GAPDH	9	29	97	12	1
GSK3B	27	30	186	8	0
GTPBP4	13	4	48	20	49
HDAC6	16	19	167	1	2
HELLS	2	2	27	1	0
HERC1	0	0	7	0	23
HIF1A	28	36	139	0	0
HSP90AA1	51	57	369	23	0
HSPA1A	1	7	318	0	0
ISG15	3	6	73	0	2
KCNA3	2	2	98	0	0
KDM8	1	1	5	0	0
KPNA1	32	15	77	30	4
LHPP	0	1	1	0	6
MAPK1	19	34	123	5	12
MDM2	47	61	261	0	0
MYC	66	90	1269	2	0
MYL2	0	4	3	0	2
NPM1	112	30	347	208	0
OTUB2	3	17	11	0	1
PAEP	0	12	2	0	0
PCBP1	10	18	80	2	1
PIN1	16	116	59	0	2
PML	12	15	159	5	0
PRDX2	1	6	27	4	12
PRKN	11	11	1405	0	0
RAF1	32	42	196	14	0
REV3L	1	2	4	0	0
STK4	23	17	947	24	7
STUB1	26	57	192	0	20
SVIL	1	1	20	4	0
SYCP1	0	0	1	0	0
TP53	123	166	704	5	0
TRAF4	11	74	34	0	0
TRAF6	31	60	155	0	3
TRIM25	3	3	190	0	0
TRIM33	6	3	52	4	0
TRIM35	0	0	3	0	14
TRIM55	1	2	19	0	0
TRIM63	8	10	36	0	0
UCHL1	5	29	31	1	0
USP7	28	28	212	7	11
YAP1	31	32	304	10	0
Show allShow less

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CLIP1	7	2	13	48	0
FDPS	0	6	8	7	1
PAWR	4	5	18	2	5
TRUB1	0	1	0	2	2

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene PKM is associated with 7 reactions in 4 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Pyrimidine metabolism	Cytosol, Mitochondria, Extracellular, Nucleus, Endoplasmic reticulum	71	78	2
Purine metabolism	Cytosol, Extracellular, Lysosome, Mitochondria, Peroxisome, Nucleus	136	101	3
Glycolysis / Gluconeogenesis	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Nucleus	73	59	1
Pyruvate metabolism	Cytosol, Mitochondria	47	38	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PKM-201	P14618	A0A024R5Z9	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	531 aa 58.1 kDa	No	0
PKM-202	P14618	V9HWB8	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	531 aa 57.9 kDa	No	0
PKM-203		B4DNK4	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	457 aa 49.9 kDa	No	0
PKM-204		H3BTN5	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	485 aa 53 kDa	No	0
PKM-206		H3BUW1	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	162 aa 17.8 kDa	No	0
PKM-209		H3BTJ2	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	168 aa 18.5 kDa	No	0
PKM-214		A0A804F729	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	605 aa 65.9 kDa	No	0
PKM-215		A0A804F6T5	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	566 aa 61.6 kDa	No	0
PKM-216		H3BU13	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	82 aa 9 kDa	No	0
PKM-217		H3BT25	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	151 aa 16.4 kDa	No	0
PKM-219	P14618	A0A024R5Z9	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	531 aa 58.1 kDa	No	0
PKM-221		H3BN34	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	51 aa 5.6 kDa	No	0
PKM-225			Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	605 aa 65.8 kDa	No	0
Show allShow less