General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes FDA approved drug targets Human disease related genes Nuclear receptors Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
p24.2
Chromosome location (bp)
24687887 - 25597932
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors 1. The RXRA/RARB heterodimer can act as a repressor on the DR1 element and as an activator on the DR5 element 2. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
DNA-binding, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]...show less
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001657[ureteric bud development] GO:0002068[glandular epithelial cell development] GO:0003417[growth plate cartilage development] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0008283[cell population proliferation] GO:0009755[hormone-mediated signaling pathway] GO:0012501[programmed cell death] GO:0021756[striatum development] GO:0022008[neurogenesis] GO:0030154[cell differentiation] GO:0032331[negative regulation of chondrocyte differentiation] GO:0035116[embryonic hindlimb morphogenesis] GO:0035264[multicellular organism growth] GO:0043065[positive regulation of apoptotic process] GO:0043068[positive regulation of programmed cell death] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048048[embryonic eye morphogenesis] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:0055012[ventricular cardiac muscle cell differentiation] GO:0060348[bone development] GO:0061037[negative regulation of cartilage development] GO:0072089[stem cell proliferation] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000647[negative regulation of stem cell proliferation]
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0030154[cell differentiation] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:1990837[sequence-specific double-stranded DNA binding]
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0030154[cell differentiation] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:1990837[sequence-specific double-stranded DNA binding]
Housekeeping in single nuclei brain Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC CollecTRI - Gene Regulatory Network Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0030154[cell differentiation] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:1990837[sequence-specific double-stranded DNA binding]
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0030154[cell differentiation] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:1990837[sequence-specific double-stranded DNA binding]
Housekeeping in single nuclei brain Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC CollecTRI - Gene Regulatory Network Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0030154[cell differentiation] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:1990837[sequence-specific double-stranded DNA binding]
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0030154[cell differentiation] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:1990837[sequence-specific double-stranded DNA binding]
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0030154[cell differentiation] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:1990837[sequence-specific double-stranded DNA binding]
Housekeeping in single nuclei brain Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC CollecTRI - Gene Regulatory Network Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye
Housekeeping in single nuclei brain Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC CollecTRI - Gene Regulatory Network Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye
Housekeeping in single nuclei brain Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains CollecTRI - Gene Regulatory Network Cancer-related genes Candidate cancer biomarkers Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Cancers Cancers of the digestive system Cancers of the lung and pleura Congenital malformations Congenital malformations of eye Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0004879[nuclear receptor activity] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0007165[signal transduction] GO:0008270[zinc ion binding] GO:0009755[hormone-mediated signaling pathway] GO:0030154[cell differentiation] GO:0043565[sequence-specific DNA binding] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048384[retinoic acid receptor signaling pathway] GO:0048566[embryonic digestive tract development] GO:1990837[sequence-specific double-stranded DNA binding]
Show all
336 aa
37.9 kDa
No
0
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