Protein interactions - SIRT6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SIRT6
Synonyms
Gene descriptionⁱ Full gene name according to HGNC.	Sirtuin 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Colonocytes & Enterocytes - Gastrointestinal absorption & barrier (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Colonocytes)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Transcription (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Vesicles
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	19
Cytoband	p13.3
Chromosome location (bp)	4174109 - 4182566
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6
Ensembl	ENSG00000077463 (version 109)
Entrez gene	51548
HGNC	HGNC:14934
UniProt	Q8N6T7
GeneCards	SIRT6

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Transcription

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Predicted location

Cell type specificity

Protein class

In same cell type

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Interaction:

Color scheme:

Confidence

Antibodies

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CHD3	23	15	100	4	7
FYCO1	6	9	8	1	12
G3BP1	35	15	146	69	1
GFPT2	1	2	2	0	9
H2AC21	13	5	24	11	56
NCAPD2	3	3	12	2	17
RELA	36	58	174	13	0
VIM	36	88	109	14	25

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Predicted location

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Protein class

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Number of interactions:

View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CHD3	23	15	100	4	7
MYC	66	90	1269	2	0
RELA	36	58	174	13	0
VIM	36	88	109	14	25

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Subcell location

Predicted location

Cell type specificity

Protein class

In same cell type

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ABCF2	0	0	12	3	2
AKT1	53	143	197	2	4
ANAPC1	9	3	33	12	10
CAPRIN1	16	3	49	135	0
CCNDBP1	7	85	10	0	2
CDC27	19	16	55	17	7
CDKN1B	28	32	58	2	14
CHD3	23	15	100	4	7
CHD4	13	3	188	17	0
DDB2	14	4	40	1	23
ELF5	0	2	3	0	0
FYCO1	6	9	8	1	12
G3BP1	35	15	146	69	1
GFPT1	0	1	6	0	0
GFPT2	1	2	2	0	9
GTF2I	2	2	50	2	0
H2AC21	13	5	24	11	56
H3C1	26	53	300	0	14
HASPIN	1	3	5	0	2
HNRNPH1	43	32	128	85	1
LMNA	17	54	239	32	3
MCM2	40	48	108	10	21
MDM2	47	61	261	0	0
MSH6	6	3	42	16	3
MUTYH	0	1	9	0	0
MYBBP1A	5	3	62	14	0
NCAPD2	3	3	12	2	17
NPM1	112	30	347	208	0
PARP1	80	28	281	158	1
PIAS1	8	38	66	4	0
PRKDC	11	13	143	17	1
RAD9A	4	3	33	0	3
RELA	36	58	174	13	0
RNF20	6	13	33	3	3
RNF40	10	10	26	39	0
RUVBL1	52	16	129	29	39
SART3	21	14	60	12	12
SMARCA5	15	18	76	27	7
STUB1	26	57	192	0	20
SUPT5H	37	8	68	91	0
TCOF1	3	4	27	0	0
TRIM25	3	3	190	0	0
TRIM28	109	24	346	68	94
TSPYL2	5	28	15	0	6
UBE3A	8	8	117	1	0
UBR5	5	5	96	2	4
USP10	5	8	73	1	0
USP48	0	1	47	0	1
USP54	7	5	13	6	0
VIM	36	88	109	14	25
WAPL	7	7	25	3	0
XRCC5	14	18	135	13	2
XRCC6	21	23	231	15	2
ZNF318	0	0	7	6	0
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Subcell location

Predicted location

Cell type specificity

Protein class

In same cell type

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ANKS1A	3	4	13	0	14
DHFR	0	1	2	2	44
FYCO1	6	9	8	1	12
G3BP1	35	15	146	69	1
GFPT2	1	2	2	0	9
H2AC20	3	0	50	0	35
H2AC21	13	5	24	11	56
H2AZ1	19	7	89	0	28
H2BC17	0	2	20	0	5
H2BC5	4	2	44	25	4
H3-7	0	0	2	0	27
H4C1	32	56	356	0	5
H4C11	0	56	1	0	5
H4C12	1	56	2	0	5
H4C13	2	56	3	0	5
H4C14	4	56	6	0	5
H4C15	0	56	1	0	5
H4C16	8	56	21	19	5
H4C2	1	56	3	0	5
H4C3	3	56	5	0	5
H4C4	0	56	1	0	5
H4C5	0	56	0	0	5
H4C6	3	56	5	0	5
H4C8	0	56	1	0	5
H4C9	7	56	15	0	5
NCAPD2	3	3	12	2	17
QRICH1	6	36	7	1	18
RGL3	0	6	0	0	24
RGPD8	1	0	2	0	14
SYMPK	6	5	25	6	12
TONSL	7	2	18	5	26
XPC	8	4	33	7	8
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene SIRT6 is associated with 5 reactions in 2 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Nicotinate and nicotinamide metabolism	Cytosol, Mitochondria, Extracellular, Peroxisome, Nucleus	46	44	2
Histidine metabolism	Cytosol, Mitochondria	56	41	3

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SIRT6-201	Q8N6T7		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	328 aa 36.1 kDa	No	0
SIRT6-202	Q8N6T7		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	355 aa 39.1 kDa	No	0
SIRT6-203		M0R1N9	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	176 aa 19.1 kDa	No	0
SIRT6-208		M0QZ09	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	275 aa 30.4 kDa	No	0
SIRT6-214		M0QXA0	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	187 aa 20.1 kDa	No	0
SIRT6-215		M0R1F6	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	186 aa 20.2 kDa	No	0
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