The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Moderate nuclear positivity was observed in lymphoid tissues. Neuronal cells exhibited weak to moderate nuclear staining. Moderate cytoplasmic positivity was displayed in renal tubules. Remaining normal tissues were in general negative.
Most normal tissues showed moderate to strong nuclear staining. Inflammatory cells and endothelial cells were strongly stained. The neuropil, gastrointestinal tract, squamous epithelium of esophagus and oral mucosa, islets of Langerhans, parathyroid, placenta, prostate, salivary gland and uterine gland were negative.
Cells in CNS, lymphoid tissues, adrenal gland, thyroid, testis, skeletal and heart muscle cells showed moderate to strong nuclear positivity. Breast and duodenum exhibited strong cytoplasmic immunoreactivity. Other normal tissues were weakly stained or negative.