Metabolic subsystems - ACOX3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACOX3
Synonyms
Gene descriptionⁱ Full gene name according to HGNC.	Acyl-CoA oxidase 3, pristanoyl
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	Enzymes Housekeeping proteins Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Syncytiotrophoblasts - Placental homeostasis & endocrine signal (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Esophagus - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Peroxisomes
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	4
Cytoband	p16.1
Chromosome location (bp)	8366282 - 8440723
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4
Ensembl	ENSG00000087008 (version 109)
Entrez gene	8310
HGNC	HGNC:121
UniProt	O15254
GeneCards	ACOX3

METABOLIC SUMMARYⁱ

ACOX3 is part of the metabolic models of 54 of 54 cell type groups and 155 of 155 cell types. In the cell types it is associated with 3 to 63 reactions in 14 subsystems, most in Beta oxidation of even-chain fatty acids (peroxisomal), Leukotriene metabolism, Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal) and others, and present in the compartments Peroxisome, Mitochondria and Cytosol.

Cell type groups

Cell types

Subsystems

Compartments

# Reactions

# Metabolites