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BETA
  • SUMMARY

  • TISSUE

  • BRAIN

  • SINGLE CELL

  • IMMUNE

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  • BLOOD

  • CELL LINE

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  • GNAS
ISOFORM
Isoform resource
Isoform methods
GENERAL INFORMATIONi

General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.

Gene namei

Official gene symbol, which is typically a short form of the gene name, according to HGNC.

GNAS
Gene descriptioni

Full gene name according to HGNC.

GNAS complex locus
Protein classi

Assigned HPA protein class(es) for the encoded protein(s).

Cancer-related genes
Disease related genes
Housekeeping proteins
Human disease related genes
Potential drug targets
Transporters
Predicted locationi

All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.

  • Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
  • Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).

The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.

Membrane, Intracellular
Number of transcriptsi

Number of protein-coding transcripts from the gene as defined by Ensembl.

50
HUMAN PROTEIN ATLAS INFORMATIONi

Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.

Tissue specificity HPA (aggregated)i

The aggregated tissue specificity category corresponds to the combined unique specificity categories of all individual isoforms for the gene, based on HPA RNA-seq data

Read more
Enhanced, enriched, low specificity
Tissue expression
cluster (RNA)i

The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.

Non-specific - Basic cellular processes (mainly)
Expression category (HPA)i

The expression category reflects the overall expression pattern for the gene based on expression profiles for all individual isoforms.

Read more
Many expressed
Tissue specificity (RNA)i

The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.

Low tissue specificity
TRANSCRIPT OVERVIEW
RNA ISOFORM EXPRESSION (HPA)
Expression
Predicted location
Organ
Expression
Alphabetical
Expression: many expressed
Specificity: enhanced;enriched;low specificity
RNA ISOFORM EXPRESSION (GTEx)
Expression
Predicted location
Organ
Expression
Alphabetical
PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.

Splice variant SwissProt TrEMBL Protein class Length & mass Signal peptide
(predicted)
Transmembrane regions
(predicted)
GNAS-201 P63092
Housekeeping proteins
Transporters
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Potential drug targets
Human disease related genes
Mapped to neXtProt
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
379 aa
44.2 kDa
No 0
GNAS-202 A0A0A0MR13
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
362 aa
41.8 kDa
No 0
GNAS-203 A0A8I5F5B5
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
690 aa
74.9 kDa
No 0
GNAS-204 O95467
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Protein evidence (Ezkurdia et al 2014)
Show all
245 aa
28 kDa
No 0
GNAS-205 A2A2R6
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
72 aa
8.2 kDa
No 0
GNAS-206 Q5JWE9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
1022 aa
109.5 kDa
No 0
GNAS-207 P63092
Housekeeping proteins
Transporters
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Potential drug targets
Human disease related genes
Mapped to neXtProt
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
395 aa
45.8 kDa
No 0
GNAS-208 O95467
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Protein evidence (Ezkurdia et al 2014)
Show all
245 aa
28 kDa
No 0
GNAS-209 Q5JWD1
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
87 aa
9.6 kDa
No 0
GNAS-210 P63092
A0A0S2Z3H8
Housekeeping proteins
Transporters
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Potential drug targets
Human disease related genes
Mapped to neXtProt
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
394 aa
45.7 kDa
No 0
GNAS-211 P63092
A0A0S2Z3S5
Housekeeping proteins
Transporters
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Potential drug targets
Human disease related genes
Mapped to neXtProt
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
380 aa
44.3 kDa
No 0
GNAS-212 O95467
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Protein evidence (Ezkurdia et al 2014)
Show all
245 aa
28 kDa
No 0
GNAS-214 Q5JWF2
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
1037 aa
111 kDa
No 0
GNAS-215 Q5JWF2
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Protein evidence (Ezkurdia et al 2014)
Show all
1023 aa
109.6 kDa
No 0
GNAS-216 O95467
H0Y7Z6
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Protein evidence (Ezkurdia et al 2014)
Show all
245 aa
28 kDa
No 0
GNAS-217 H0Y7E8
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
730 aa
75 kDa
No 0
GNAS-218 O95467
A2A2S1
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Disease related genes
Human disease related genes
Mapped to neXtProt
Protein evidence (Ezkurdia et al 2014)
Show all
245 aa
28 kDa
No 0
GNAS-219 A0A590UJ46
Housekeeping proteins
Predicted membrane proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
285 aa
30.9 kDa
No 2
GNAS-220 A0A590UK28
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
321 aa
37.6 kDa
No 0
GNAS-222 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-223 A0A590UJX3
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
28 aa
3 kDa
No 0
GNAS-224 A0A590UK28
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
321 aa
37.6 kDa
No 0
GNAS-225 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-226 A0A590UJS2
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
368 aa
42.6 kDa
No 0
GNAS-227 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-228 A0A590UJQ9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
336 aa
39.1 kDa
No 0
GNAS-229 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-232 A0A590UJF0
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
320 aa
37.5 kDa
No 0
GNAS-233 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-234 A0A590UK28
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
321 aa
37.6 kDa
No 0
GNAS-236 A0A590UJQ9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
336 aa
39.1 kDa
No 0
GNAS-237 A0A590UJF0
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
320 aa
37.5 kDa
No 0
GNAS-238 A0A590UK28
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
321 aa
37.6 kDa
No 0
GNAS-240 A0A590UJF0
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
320 aa
37.5 kDa
No 0
GNAS-242 A0A590UJ47
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
13 aa
1.5 kDa
No 0
GNAS-243 A0A590UK28
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
321 aa
37.6 kDa
No 0
GNAS-246 A0A590UK28
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
321 aa
37.6 kDa
No 0
GNAS-247 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-249 A0A590UJ47
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
13 aa
1.5 kDa
No 0
GNAS-250 A0A590UK28
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
321 aa
37.6 kDa
No 0
GNAS-251 A0A590UJX3
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
28 aa
3 kDa
No 0
GNAS-255 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-256 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-257 A0A590UJY2
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
237 aa
27.9 kDa
No 0
GNAS-258 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-259 A0A590UJQ9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
336 aa
39.1 kDa
No 0
GNAS-260 B0AZR9
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
335 aa
39 kDa
No 0
GNAS-261 A0A7I2V5R6
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
1038 aa
111.1 kDa
No 0
GNAS-267 A0A804HIH4
Housekeeping proteins
Predicted intracellular proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
285 aa
33.6 kDa
No 0
GNAS-271 A0A590UJ46
Housekeeping proteins
Predicted membrane proteins
Cancer-related genes
Human disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
285 aa
30.9 kDa
No 2
Show allShow less

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