General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Housekeeping proteins Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p36.11
Chromosome location (bp)
27098809 - 27166981
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Electroneutral Na(+) /H(+) antiporter that extrudes Na(+) in exchange for external protons driven by the inward sodium ion chemical gradient, protecting cells from acidification that occurs from metabolism 1,2,3,4,5,6,7,8,9,10,11,12. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (By similarity). Plays a key role in maintening intracellular pH neutral and cell volume, and thus is important for cell growth, proliferation, migration and survival 13,14,15,16. In addition, can transport lithium Li(+) and also functions as a Na(+)/Li(+) antiporter 17. SLC9A1 also functions in membrane anchoring and organization of scaffolding complexes that coordinate signaling inputs 18....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Calmodulin-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Antiport, Ion transport, Sodium transport, Transport
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Sodium
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a Na+/H+ antiporter that is a member of the solute carrier family 9. The encoded protein is a plasma membrane transporter that is expressed in the kidney and intestine. This protein plays a central role in regulating pH homeostasis, cell migration and cell volume. This protein may also be involved in tumor growth. [provided by RefSeq, Sep 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins Housekeeping proteins Housekeeping in single cell types Housekeeping in tissues Housekeeping in single nuclei brain Housekeeping in cell lines Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Human disease related genes Nervous system diseases Neurodegenerative diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) deepTMHMM predicted membrane proteins
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GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006811[ion transport] GO:0006812[cation transport] GO:0006814[sodium ion transport] GO:0006883[cellular sodium ion homeostasis] GO:0006885[regulation of pH] GO:0010447[response to acidic pH] GO:0010613[positive regulation of cardiac muscle hypertrophy] GO:0010882[regulation of cardiac muscle contraction by calcium ion signaling] GO:0015297[antiporter activity] GO:0015299[solute:proton antiporter activity] GO:0015385[sodium:proton antiporter activity] GO:0015386[potassium:proton antiporter activity] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0016477[cell migration] GO:0030011[maintenance of cell polarity] GO:0030027[lamellipodium] GO:0030346[protein phosphatase 2B binding] GO:0030674[protein-macromolecule adaptor activity] GO:0035994[response to muscle stretch] GO:0036376[sodium ion export across plasma membrane] GO:0043167[ion binding] GO:0045121[membrane raft] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048306[calcium-dependent protein binding] GO:0051259[protein complex oligomerization] GO:0051453[regulation of intracellular pH] GO:0051492[regulation of stress fiber assembly] GO:0051893[regulation of focal adhesion assembly] GO:0055085[transmembrane transport] GO:0060090[molecular adaptor activity] GO:0070062[extracellular exosome] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0071260[cellular response to mechanical stimulus] GO:0071468[cellular response to acidic pH] GO:0071805[potassium ion transmembrane transport] GO:0071872[cellular response to epinephrine stimulus] GO:0086036[regulation of cardiac muscle cell membrane potential] GO:0086040[sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential] GO:0086092[regulation of the force of heart contraction by cardiac conduction] GO:0090533[cation-transporting ATPase complex] GO:0098719[sodium ion import across plasma membrane] GO:0098735[positive regulation of the force of heart contraction] GO:1902600[proton transmembrane transport] GO:1903281[positive regulation of calcium:sodium antiporter activity]
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555 aa
61 kDa
No
>9
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