Protein interactions - COMT - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COMT
Synonyms
Gene descriptionⁱ Full gene name according to HGNC.	Catechol-O-methyltransferase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Basic cellular functions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Esophageal basal cells, Esophageal suprabasal cells, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Vesicles In addition localized to the Endoplasmic reticulum
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	22
Cytoband	q11.21
Chromosome location (bp)	19941371 - 19969975
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12
Ensembl	ENSG00000093010 (version 109)
Entrez gene	1312
HGNC	HGNC:2228
UniProt	P21964
GeneCards	COMT

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

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Consensus

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
SLC7A1	5	47	43	0	17
TMEM205	1	15	2	0	7
TRIP13	11	72	19	0	6

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AVPR2	0	2	2	0	0
BEST2	0	14	0	0	0
CCL4L2	0	31	0	0	0
CNR2	1	22	1	0	0
CREB3L1	4	163	5	0	0
EMD	16	72	94	12	0
FAM209A	0	200	0	0	0
FFAR3	0	12	0	0	0
GET1	1	27	1	2	1
GJB1	0	37	4	0	0
GJB3	0	11	0	0	2
GJB4	0	8	0	0	0
GJB5	0	32	0	0	0
GPR152	0	164	0	0	0
GPR161	0	4	2	0	0
GPR42	0	88	0	0	0
HIBADH	0	31	1	1	2
HSD3B7	3	42	3	0	0
KCNK5	0	24	0	0	0
MFSD14B	0	61	0	0	0
MYADML2	0	10	0	0	0
NIPAL4	0	15	0	0	0
PLPP6	0	45	0	0	1
REEP4	12	93	12	13	15
RHBDL1	0	9	0	0	0
S1PR3	0	3	0	0	0
SELENOK	0	24	4	0	0
SLC10A6	0	124	0	0	0
SLC16A7	0	13	0	0	0
SLC2A5	1	8	3	0	0
SLC35A4	0	23	0	0	0
SLC35F1	1	6	2	0	0
SLC39A1	1	7	1	0	0
SLC39A2	0	45	0	0	0
SLC48A1	0	6	0	0	0
SLC7A1	5	47	43	0	17
SLC7A8	0	25	1	0	0
SMIM1	0	48	0	0	0
THSD7A	0	12	0	0	1
TLCD4	0	61	1	0	1
TMEM100	0	32	0	0	0
TMEM120B	1	47	2	1	3
TMEM14B	1	193	1	0	0
TMEM14C	0	35	0	0	0
TMEM187	0	13	0	0	0
TMEM205	1	15	2	0	7
TMEM222	0	30	0	0	0
TMEM50A	0	9	0	0	0
TRHR	0	14	0	0	2
TRIP13	11	72	19	0	6
VAMP3	25	46	38	62	23
VAMP5	23	58	31	0	41
WFS1	0	316	2	2	20
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CDC42	30	33	160	15	1
RUFY1	2	5	32	0	0
SLC7A1	5	47	43	0	17
TMEM205	1	15	2	0	7
TRIP13	11	72	19	0	6

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
VAPA	74	40	114	140	0

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene COMT is associated with 21 reactions in 4 different subsystems, and present in the compartments: Cytosol, Endoplasmic reticulum. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Golgi apparatus	524	320	1
Phenylalanine, tyrosine and tryptophan biosynthesis	Cytosol, Endoplasmic reticulum, Mitochondria	133	182	12
Estrogen metabolism	Cytosol, Endoplasmic reticulum, Mitochondria, Peroxisome, Lysosome	68	48	7
Serotonin and melatonin biosynthesis	Cytosol	54	40	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COMT-202	P21964	A0A140VJG8	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	271 aa 30 kDa	No	0
COMT-203		E7EUU8	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	235 aa 26 kDa	No	0
COMT-204	P21964	A0A140VJG8	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	271 aa 30 kDa	No	0
COMT-205	P21964	A0A140VJG8	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	271 aa 30 kDa	No	0
COMT-206	P21964	A0A140VJG8	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	271 aa 30 kDa	No	0
COMT-207		E7EMS6	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	223 aa 24.8 kDa	No	0
COMT-208		H7BZ45	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	292 aa 32.4 kDa	No	0
COMT-209	P21964		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	221 aa 24.4 kDa	No	0
COMT-212	P21964	A0A140VJG8	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	271 aa 30 kDa	No	0
COMT-218	P21964	A0A140VJG8	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	271 aa 30 kDa	No	0
COMT-219		A0A7I2V370	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	302 aa 33.5 kDa	No	0
COMT-220	P21964	A0A140VJG8	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes FDA approved drug targets Human disease related genes Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	271 aa 30 kDa	No	0
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