Protein interactions - NAA10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NAA10
Synonyms	ARD1, ARD1A, DXS707, TE2
Gene descriptionⁱ Full gene name according to HGNC.	N-alpha-acetyltransferase 10, NatA catalytic subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Essential proteins Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cellular respiration (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Megakaryocytes)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol In addition localized to the Nucleoli
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	X
Cytoband	q28
Chromosome location (bp)	153929225 - 153935080
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6
Ensembl	ENSG00000102030 (version 109)
Entrez gene	8260
HGNC	HGNC:18704
UniProt	P41227
GeneCards	NAA10

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Basic cellular processes

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CDCA5	6	6	16	3	1
EHMT2	10	29	57	0	0
HIF1A	28	36	139	0	0
HYPK	4	5	17	0	3
NAA15	4	4	10	0	0
NAA16	2	3	3	0	2
NAA50	2	5	5	0	0

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACOT12	1	6	1	0	0
APP	44	313	141	1	0
ARHGEF6	5	14	14	5	0
ARHGEF7	14	15	27	10	0
CALCOCO2	21	118	59	0	5
CCDC106	2	15	3	0	3
CCDC174	1	3	1	1	1
CDCA5	6	6	16	3	1
CEP44	5	40	13	0	0
CFTR	34	103	236	0	0
CREBRF	0	3	0	0	0
DDIT4L	1	169	1	0	0
DHX57	1	18	12	0	21
EHMT2	10	29	57	0	0
FIP1L1	2	5	19	6	0
HIF1A	28	36	139	0	0
KIFAP3	3	16	11	3	6
KRTAP10-5	10	115	10	0	0
KRTAP10-6	0	65	0	0	0
KRTAP10-7	8	239	10	0	0
MCRS1	9	98	40	0	0
MDM4	11	23	28	1	2
MEOX2	4	158	10	0	0
MKRN1	3	14	18	1	0
MRPS11	0	1	12	1	0
NAA15	4	4	10	0	0
NAA16	2	3	3	0	2
NAA50	2	5	5	0	0
NFE2L2	38	46	69	0	0
PDE4DIP	5	31	17	5	0
PLSCR3	0	26	2	0	0
PPP2R3B	3	4	6	1	2
RAB3IP	4	27	5	2	0
RAC1	33	61	111	15	0
RBCK1	6	21	45	0	2
RCN3	1	6	2	0	0
SNX33	4	13	4	1	11
SSX2IP	9	81	32	3	0
TAF7L	0	1	3	0	0
TSEN54	3	15	3	0	0
ZBTB14	1	54	6	0	1
ZNF202	0	17	0	0	0
ZNF655	2	117	3	5	0
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CDC25A	6	7	29	2	0
CDCA5	6	6	16	3	1
CTNNB1	47	85	285	13	13
EHMT2	10	29	57	0	0
HIF1A	28	36	139	0	0
HIF1AN	23	19	58	0	18
HSPA4	16	5	129	54	5
HYPK	4	5	17	0	3
NAA15	4	4	10	0	0
NAA16	2	3	3	0	2
NAA50	2	5	5	0	0
OFD1	8	13	51	2	0
PDHA1	4	4	101	2	1
PGK1	4	5	32	5	1
PSME2	12	6	31	6	10
SERBP1	16	6	151	35	0
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
INPPL1	5	4	19	31	12

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
HYPK	4	5	17	0	3
MRPL42	14	2	25	2	97
NAA11	1	12	1	0	1
NAA16	2	3	3	0	2
PTCD2	0	2	0	0	4
RBP4	1	2	1	0	5
SPATA46	1	10	1	0	11
WASHC3	15	45	18	7	22
WIF1	0	4	0	0	87

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene NAA10 is associated with 3 reactions in 2 different subsystems, and present in the compartments: Cytosol, Nucleus. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Histidine metabolism	Cytosol, Mitochondria	56	41	1
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	2

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAA10-201	P41227		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	220 aa 24.8 kDa	No	0
NAA10-202		C9JN83	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	142 aa 16.7 kDa	No	0
NAA10-203		F8W808	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	169 aa 19.4 kDa	No	0
NAA10-205		A8MWP7	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	184 aa 21.2 kDa	No	0
NAA10-206		C9JW55	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	145 aa 16.9 kDa	No	0
NAA10-208	P41227		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	235 aa 26.5 kDa	No	0
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