Protein interactions - PDHA1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PDHA1
Synonyms	E1alpha, PDHA
Gene descriptionⁱ Full gene name according to HGNC.	Pyruvate dehydrogenase E1 subunit alpha 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Citric acid cycle related proteins Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cellular respiration (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Oocytes, Parietal cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Striated muscle - Muscle contraction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Heart muscle, Skeletal muscle, Tongue)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	X
Cytoband	p22.12
Chromosome location (bp)	19343893 - 19361718
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5
Ensembl	ENSG00000131828 (version 109)
Entrez gene	5160
HGNC	HGNC:8806
UniProt	P08559
GeneCards	PDHA1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Striated muscle - Muscle contraction

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
IMMT	8	11	65	2	0
PDHB	2	3	30	5	0
PDK1	1	4	35	0	0
STAT5A	7	8	28	0	5

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CFTR	34	103	236	0	0
IMMT	8	11	65	2	0
PDHB	2	3	30	5	0
PDK1	1	4	35	0	0

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Number of interactions:

101

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACAD9	5	0	39	0	16
ACAT1	0	0	12	1	2
ACE2	10	13	278	0	0
AGPS	1	1	11	3	0
ATAD3A	0	3	33	1	0
ATP1A1	5	4	53	5	1
ATP2A2	2	4	42	0	0
ATP5F1A	9	8	71	2	11
ATP5F1B	10	14	76	1	15
ATP5F1C	2	2	44	1	0
BCKDHA	2	2	10	0	18
BSG	4	5	87	8	0
C17orf80	0	2	8	6	0
CEBPB	4	6	72	0	0
CLPP	2	19	211	0	5
CORO1C	3	1	29	4	16
COX4I1	2	5	105	2	1
CS	0	0	186	4	0
CYB5R3	9	51	22	16	0
DHX30	9	6	41	33	0
DLAT	3	3	21	4	1
DLD	2	6	37	1	2
DLST	2	55	25	1	2
DYNC1H1	17	37	61	33	1
ECI2	1	2	11	0	0
ELAVL1	19	3	149	26	0
FASTKD3	0	3	2	0	2
FASTKD5	1	3	7	0	17
GATD3	0	1	21	1	0
GFM1	4	1	21	3	4
GFM2	0	4	3	0	0
HADHA	4	9	49	4	10
HECTD1	2	1	92	2	4
HINT2	1	0	20	0	4
HNRNPDL	11	6	41	29	0
HSD17B10	5	5	44	3	0
HSDL2	0	0	11	1	0
HSPA9	9	12	81	4	12
IARS2	0	0	24	6	2
IMMT	8	11	65	2	0
LRPPRC	7	7	68	8	2
LRRC59	5	14	90	13	0
MDH2	1	0	34	7	0
METTL15	6	1	10	0	26
MRPS26	34	0	57	4	65
MRRF	1	7	12	0	0
MTCH2	0	1	75	0	5
MTIF2	12	0	40	0	20
MTRF1L	0	0	6	0	1
MYC	66	90	1269	2	0
NAA10	7	43	16	1	9
NCBP1	19	12	51	33	5
NDUFA4	0	1	48	0	0
NDUFS1	6	3	51	2	9
NDUFS2	11	5	39	0	13
NDUFS3	16	7	78	0	13
NDUFS6	14	1	24	0	50
NDUFS7	24	2	50	0	60
NDUFV1	3	17	44	0	0
NGRN	9	2	23	0	24
NIPSNAP1	2	5	23	1	0
NNT	0	0	10	1	0
NR3C1	4	10	104	3	1
OGDH	1	2	14	0	2
PDHB	2	3	30	5	0
PDHX	3	5	8	0	1
PDK1	1	4	35	0	0
PDK3	1	2	21	0	3
PDP1	0	3	5	0	0
PHB1	2	7	130	1	0
PHB2	2	4	81	2	1
PPT1	1	4	25	1	0
PRKN	11	11	1405	0	0
PTBP1	6	7	53	3	0
PYCR1	4	1	17	6	9
PYCR2	4	0	16	13	7
RAB7A	30	11	131	36	1
RPA1	7	10	420	1	1
RPA3	5	6	314	1	1
SDHA	4	7	30	2	9
SDHB	1	7	18	1	1
SERPINH1	0	27	23	4	0
SFXN1	2	15	93	2	9
SHMT2	3	9	30	0	3
SIRT3	3	4	19	0	6
SSBP1	2	4	61	0	6
STAT5A	7	8	28	0	5
STOML2	0	3	14	1	0
TACO1	0	15	7	0	0
TBRG4	0	18	9	0	0
TEFM	1	1	3	8	3
TFAM	3	8	34	5	0
TOMM22	3	5	31	1	21
TOMM40	10	2	38	11	26
TRAP1	2	1	33	15	1
TSFM	3	8	20	1	6
UQCRC1	3	29	21	2	1
UQCRC2	2	6	42	0	1
VDAC1	9	15	77	22	2
VDAC2	8	21	62	8	0
VWA8	0	0	15	5	0
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
POLR3E	22	1	30	30	16
RBSN	4	4	7	2	5

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
STAT5A	7	8	28	0	5

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene PDHA1 is associated with 2 reactions in 2 different subsystems, and present in the compartments: Mitochondria. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Glycolysis / Gluconeogenesis	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Nucleus	73	59	1
Thiamine metabolism	Mitochondria, Cytosol	6	13	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDHA1-201		Q5JPT9	Metabolic proteins Predicted intracellular proteins Citric acid cycle related proteins Human disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	397 aa 44.1 kDa	No	0
PDHA1-204		Q5JPU2	Metabolic proteins Predicted intracellular proteins Citric acid cycle related proteins Human disease related genes Protein evidence (Ezkurdia et al 2014) Show all	418 aa 46.4 kDa	No	0
PDHA1-205	P08559	A0A024RBX9	Enzymes Metabolic proteins Predicted intracellular proteins Citric acid cycle related proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	390 aa 43.3 kDa	No	0
PDHA1-206		Q5JPU1	Metabolic proteins Predicted intracellular proteins Citric acid cycle related proteins Human disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	428 aa 47.6 kDa	No	0
PDHA1-211	P08559		Enzymes Metabolic proteins Predicted intracellular proteins Citric acid cycle related proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	359 aa 40.2 kDa	No	0
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