Protein interactions - ECI2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ECI2
Synonyms	ACBD2, DRS1, HCA88, PECI
Gene descriptionⁱ Full gene name according to HGNC.	Enoyl-CoA delta isomerase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Basic cellular functions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Hepatocytes, Migrating cytotrophoblasts, Parietal cells, Respiratory ciliated cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Liver & Kidney - Metabolism (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Liver)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Peroxisomes, Mitochondria
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	6
Cytoband	p25.2
Chromosome location (bp)	4115693 - 4135597
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5
Ensembl	ENSG00000198721 (version 109)
Entrez gene	10455
HGNC	HGNC:14601
UniProt	O75521
GeneCards	ECI2

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Liver & Kidney - Metabolism

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Cell type specificity

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ECH1	5	6	15	0	3

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Predicted location

Cell type specificity

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Number of interactions:

View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ECH1	5	6	15	0	3
TNPO3	3	9	12	22	0

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Predicted location

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CS	0	0	186	4	0
ECH1	5	6	15	0	3
HERC2	9	6	69	0	20
MAPK6	5	8	21	2	1
NEURL4	1	3	15	2	0
PDHA1	4	4	101	2	1
PEX5	3	11	34	0	0
SOCS6	4	15	76	0	3
TRAF1	17	168	46	0	9
UBE3A	8	8	117	1	0
ZRANB1	35	112	197	0	1
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene ECI2 is associated with 70 reactions in 13 different subsystems, and present in the compartments: Mitochondria, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Beta oxidation of even-chain fatty acids (peroxisomal)	Peroxisome	9	59	12
Vitamin E metabolism	Mitochondria, Cytosol, Endoplasmic reticulum	55	68	4
Beta oxidation of phytanic acid (peroxisomal)	Peroxisome, Cytosol	13	37	3
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	70	358	11
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)	Mitochondria	13	28	2
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	7
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)	Peroxisome	9	47	11
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	38	56	9
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)	Peroxisome	9	28	6
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)	Mitochondria	12	26	1
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)	Peroxisome	9	17	2
Omega-3 fatty acid metabolism	Cytosol, Peroxisome, Nucleus, Endoplasmic reticulum	52	73	1
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)	Mitochondria	12	30	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ECI2-201		A0A0C4DGA2	Metabolic proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	364 aa 40.2 kDa	No	0
ECI2-202	O75521		Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	394 aa 43.6 kDa	No	0
ECI2-204		A0A0C4DGA2	Metabolic proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)	364 aa 40.2 kDa	No	0
ECI2-207		A0A0C4DGA2	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	364 aa 40.2 kDa	No	0
ECI2-210		C9JB63	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	220 aa 24 kDa	No	0
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