Protein interactions - CYB5R3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CYB5R3
Synonyms	DIA1
Gene descriptionⁱ Full gene name according to HGNC.	Cytochrome b5 reductase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Stratified epithelial cells - Barrier functions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Conjunctival goblet cells, Endometrial secretory cells, Epididymal basal cells, Ocular epithelial cells, Respiratory basal cells, Respiratory secretory cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Smooth muscle tissue - ECM organization (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Endoplasmic reticulum In addition localized to the Perinuclear theca, Calyx, Connecting piece, Mid piece, Principal piece
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	22
Cytoband	q13.2
Chromosome location (bp)	42615730 - 42720870
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14
Ensembl	ENSG00000100243 (version 109)
Entrez gene	1727
HGNC	HGNC:2873
UniProt	P00387
GeneCards	CYB5R3

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Smooth muscle tissue - ECM organization

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Consensus

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CANX	130	8	242	381	24
FUNDC2	1	22	3	0	19
RPN2	33	3	99	60	2
RTN4	23	13	45	66	0
STOM	5	120	14	2	21
TMED10	17	8	25	101	20
VAPA	74	40	114	140	0
VDAC1	9	15	77	22	2
VDAC2	8	21	62	8	0

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ALG8	0	9	0	0	1
AQP6	0	264	0	0	0
ASGR1	1	27	1	0	2
BNIP2	0	37	4	0	0
CANX	130	8	242	381	24
CDIPT	0	47	1	2	2
CERS4	0	40	0	0	5
CNIH1	0	21	0	0	0
CSGALNACT2	1	16	3	0	0
ELOVL4	0	79	0	0	0
FAM210B	0	55	0	0	3
FAM3C	1	45	7	2	1
FAXDC2	0	28	0	0	0
FUNDC2	1	22	3	0	19
GAST	0	17	0	0	6
GPR152	0	164	0	0	0
GRM2	1	20	4	0	0
HBA1	1	13	2	0	17
HBA2	1	13	1	0	17
HSD17B13	0	104	0	0	6
LAPTM5	2	12	7	0	0
LRCH4	3	15	4	1	0
MFSD6	0	31	0	0	0
NINJ1	0	16	0	0	0
NRM	0	50	0	0	1
NSG1	0	26	2	3	1
NXPE3	0	5	0	0	0
ORMDL2	0	18	0	1	1
PNLIPRP1	0	31	0	0	0
REEP4	12	93	12	13	15
SLC10A1	2	76	3	0	4
SLC10A6	0	124	0	0	0
SLC13A3	0	9	0	0	0
SLC35A4	0	23	0	0	0
SLC35B2	1	9	4	0	0
SLC38A7	0	43	0	0	1
STOM	5	120	14	2	21
TMEM115	0	11	0	2	0
TMEM14B	1	193	1	0	0
TMEM14C	0	35	0	0	0
TMEM51	2	33	3	0	10
TMEM60	0	86	0	0	0
TMEM79	0	32	1	0	8
TNF	3	36	34	0	0
TNFRSF10C	0	23	0	0	18
UBIAD1	1	33	8	3	0
VAMP4	11	36	15	13	0
VAMP5	23	58	31	0	41
VMP1	2	6	6	1	8
WFDC2	1	14	1	0	0
ZDHHC15	0	47	3	0	0
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Predicted location

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ANPEP	0	0	15	0	0
CANX	130	8	242	381	24
CYB5B	1	37	13	1	0
FUNDC2	1	22	3	0	19
HSPA8	65	45	457	29	101
KCNA3	2	2	98	0	0
MTCH1	0	0	20	0	0
PDHA1	4	4	101	2	1
PRKN	11	11	1405	0	0
PRNP	9	17	294	0	0
RAB5C	10	7	60	0	7
REEP6	5	12	7	1	24
RPN1	33	10	135	65	3
RPN2	33	3	99	60	2
RTN4	23	13	45	66	0
SDHA	4	7	30	2	9
SLC37A3	0	0	5	0	0
STOM	5	120	14	2	21
TMED10	17	8	25	101	20
VAPA	74	40	114	140	0
VDAC1	9	15	77	22	2
VDAC2	8	21	62	8	0
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP2A3	0	0	2	12	0
CANX	130	8	242	381	24
COPA	14	2	40	78	0
RPN2	33	3	99	60	2
RTN4	23	13	45	66	0
SACM1L	9	26	15	20	23
SGPL1	1	29	6	13	20
SPCS3	2	4	3	13	20
TMED10	17	8	25	101	20
TOMM20	6	1	20	8	11
TOMM22	3	5	31	1	21
TOMM40	10	2	38	11	26
VAPA	74	40	114	140	0
VDAC1	9	15	77	22	2
VDAC2	8	21	62	8	0
YIPF5	3	2	5	39	0
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene CYB5R3 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Nicotinate and nicotinamide metabolism	Cytosol, Mitochondria, Extracellular, Peroxisome, Nucleus	46	44	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYB5R3-201	P00387		Enzymes Metabolic proteins Transporters Predicted membrane proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	301 aa 34.2 kDa	No	1
CYB5R3-202		A0A8J8YWN6	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	345 aa 38.8 kDa	No	1
CYB5R3-203	P00387		Enzymes Metabolic proteins Transporters Predicted intracellular proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	278 aa 31.6 kDa	No	0
CYB5R3-204		A0A8J8Z3C6	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	307 aa 34.9 kDa	No	1
CYB5R3-205	P00387		Enzymes Metabolic proteins Transporters Predicted intracellular proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	278 aa 31.6 kDa	No	0
CYB5R3-206		B1AHF3	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	159 aa 17.8 kDa	No	0
CYB5R3-211		A0A8I5KVD2	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	131 aa 14.9 kDa	No	0
CYB5R3-214	P00387		Enzymes Metabolic proteins Transporters Predicted intracellular proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	278 aa 31.6 kDa	No	0
CYB5R3-216	P00387		Enzymes Metabolic proteins Transporters Predicted membrane proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	334 aa 38.2 kDa	No	1
CYB5R3-217		A0A8I5KYU1	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	201 aa 23.2 kDa	No	1
CYB5R3-219		A0A8I5QKX1	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	273 aa 31.3 kDa	No	1
CYB5R3-226	P00387		Enzymes Metabolic proteins Transporters Predicted intracellular proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	278 aa 31.6 kDa	No	0
CYB5R3-229		A0A8I5KW26	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	315 aa 35.7 kDa	No	1
CYB5R3-230		A0A8I5KR71	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	298 aa 33.9 kDa	No	1
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