Protein interactions - NDUFS2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFS2
Synonyms	CI-49
Gene descriptionⁱ Full gene name according to HGNC.	NADH:ubiquinone oxidoreductase core subunit S2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Essential proteins Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - RNA processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low cell type specificity
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cellular respiration (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Skeletal muscle, Tongue)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria In addition localized to the Calyx, Connecting piece
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161197104 - 161214723
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15
Ensembl	ENSG00000158864 (version 109)
Entrez gene	4720
HGNC	HGNC:7708
UniProt	O75306
GeneCards	NDUFS2

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Cellular respiration

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Interaction:

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
DNAJC30	8	23	13	0	38
NDUFA13	17	4	28	0	34
NDUFA7	7	6	12	0	33
NDUFA9	21	9	47	0	37
NDUFAF4	10	4	18	0	20
NDUFB3	18	1	23	3	38
NDUFB5	15	1	25	0	40
NDUFS3	16	7	78	0	13
NDUFS5	10	4	17	2	38
NDUFS6	14	1	24	0	50
NDUFS7	24	2	50	0	60
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Subcell location

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
MKLN1	9	21	11	2	25
NDUFA9	21	9	47	0	37
NDUFAF3	3	13	8	0	6
NDUFS3	16	7	78	0	13
OSMR	0	10	1	0	24

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACAD9	5	0	39	0	16
CLPP	2	19	211	0	5
COX4I1	2	5	105	2	1
CS	0	0	186	4	0
CUL3	40	45	771	2	0
DHRS4	0	0	3	0	0
DNAJC30	8	23	13	0	38
ECSIT	9	14	23	0	31
GRSF1	2	1	170	2	0
HSCB	6	18	65	0	0
HSPD1	20	38	139	11	45
LRPPRC	7	7	68	8	2
MRPL58	16	1	134	0	21
MTCH2	0	1	75	0	5
MYC	66	90	1269	2	0
NDUFA10	3	1	17	1	11
NDUFA12	7	3	32	1	12
NDUFA13	17	4	28	0	34
NDUFA4	0	1	48	0	0
NDUFA7	7	6	12	0	33
NDUFA9	21	9	47	0	37
NDUFAF4	10	4	18	0	20
NDUFB11	2	10	28	0	0
NDUFB3	18	1	23	3	38
NDUFB5	15	1	25	0	40
NDUFS1	6	3	51	2	9
NDUFS3	16	7	78	0	13
NDUFS4	5	1	32	0	10
NDUFS5	10	4	17	2	38
NDUFS6	14	1	24	0	50
NDUFS7	24	2	50	0	60
NDUFS8	8	0	43	0	12
NDUFV1	3	17	44	0	0
NDUFV2	6	60	34	2	8
NDUFV3	1	2	25	0	0
PDHA1	4	4	101	2	1
PHB1	2	7	130	1	0
PRKN	11	11	1405	0	0
TFAM	3	8	34	5	0
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Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
DNAJC30	8	23	13	0	38
GPR45	0	0	0	0	197
NDUFA1	0	0	0	0	35
NDUFA13	17	4	28	0	34
NDUFA7	7	6	12	0	33
NDUFA9	21	9	47	0	37
NDUFAF4	10	4	18	0	20
NDUFB3	18	1	23	3	38
NDUFB5	15	1	25	0	40
NDUFS5	10	4	17	2	38
NDUFS6	14	1	24	0	50
NDUFS7	24	2	50	0	60
TIMMDC1	6	53	11	0	41
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene NDUFS2 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Inner mitochondria, Mitochondria. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Oxidative phosphorylation	Mitochondria, Cytosol, Peroxisome, Endoplasmic reticulum, Inner mitochondria	106	16	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFS2-201	O75306		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	463 aa 52.5 kDa	No	0
NDUFS2-202	O75306		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	457 aa 51.9 kDa	No	0
NDUFS2-218	O75306		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	463 aa 52.5 kDa	No	0
NDUFS2-224	O75306		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	463 aa 52.5 kDa	No	0
NDUFS2-235		A0A7I2YQD8	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	431 aa 48.8 kDa	No	0
NDUFS2-240		A0A7I2YQG7	Metabolic proteins Predicted membrane proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	484 aa 54.7 kDa	No	1
NDUFS2-245	O75306		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	457 aa 51.9 kDa	No	0
NDUFS2-247		A0A7I2V596	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	478 aa 54 kDa	No	0
NDUFS2-257		A0A7I2YQG7	Metabolic proteins Predicted membrane proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	484 aa 54.7 kDa	No	1
NDUFS2-268	O75306		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	463 aa 52.5 kDa	No	0
NDUFS2-269	O75306		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	463 aa 52.5 kDa	No	0
NDUFS2-275		A0A7I2V4X8	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	438 aa 49.7 kDa	No	0
NDUFS2-279		A0A7I2V4G5	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	437 aa 49.5 kDa	No	0
NDUFS2-286	O75306		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	457 aa 51.9 kDa	No	0
NDUFS2-288		A0A7I2V5G4	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	341 aa 38.9 kDa	No	0
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