Protein interactions - ATP5F1B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP5F1B
Synonyms	ATP5B, ATPSB
Gene descriptionⁱ Full gene name according to HGNC.	ATP synthase F1 subunit beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Essential proteins Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cellular respiration (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Esophageal basal cells, Esophageal suprabasal cells, Parietal cells, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cellular respiration (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Skeletal muscle, Tongue)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	56638175 - 56645984
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5
Ensembl	ENSG00000110955 (version 109)
Entrez gene	506
HGNC	HGNC:830
UniProt	P06576
GeneCards	ATP5F1B

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Cellular respiration

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP5F1A	9	8	71	2	11
ATP5F1C	2	2	44	1	0
ATP5IF1	3	14	9	1	27
ATP5PB	14	15	31	0	53
ATP5PD	4	4	22	2	7
ATP5PF	10	16	14	3	38
ATPAF1	2	1	9	0	4
ATPAF2	4	58	8	0	8
LNX2	15	63	18	0	0
SLC35F1	1	6	2	0	0

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP5F1A	9	8	71	2	11
ATP5F1C	2	2	44	1	0
ATP5IF1	3	14	9	1	27
ATP5PB	14	15	31	0	53
ATP5PD	4	4	22	2	7
ATPAF1	2	1	9	0	4
ATPAF2	4	58	8	0	8
ATXN1	53	272	74	2	0
BYSL	42	119	57	62	8
HTR1E	0	3	0	0	0
LNX2	15	63	18	0	0
SLC35F1	1	6	2	0	0
YWHAG	254	271	433	222	13
YWHAZ	222	164	348	324	8
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACKR3	0	3	3	0	0
AGR2	3	64	227	0	2
AIFM1	3	5	139	3	0
AIMP2	9	33	60	0	2
ANLN	1	0	568	2	0
ARAF	19	16	65	11	4
ATP5F1A	9	8	71	2	11
ATP5F1C	2	2	44	1	0
ATP5F1D	3	7	17	0	3
ATP5IF1	3	14	9	1	27
ATP5ME	2	4	11	0	5
ATP5MG	1	3	11	0	10
ATP5PB	14	15	31	0	53
ATP5PD	4	4	22	2	7
ATP5PF	10	16	14	3	38
ATP5PO	6	18	34	6	8
ATP6V1B2	18	7	33	22	14
ATPAF1	2	1	9	0	4
ATPAF2	4	58	8	0	8
BLK	4	23	11	0	4
CAND1	7	7	78	0	6
CCNF	4	4	624	0	1
CDK9	17	14	125	19	0
CEP250	1	2	15	0	0
CS	0	0	186	4	0
CUL3	40	45	771	2	0
CUL7	6	1	55	3	12
EEF1A1	13	12	118	4	11
EMC2	17	9	49	18	20
ESR1	34	59	479	0	0
EZH2	16	16	236	7	0
HDAC6	16	19	167	1	2
HMOX2	8	44	15	0	25
HNRNPA3	10	2	66	35	0
HSPA5	38	32	268	25	86
HSPA8	65	45	457	29	101
HSPD1	20	38	139	11	45
HUWE1	5	5	209	2	0
ISG15	3	6	73	0	2
LNX2	15	63	18	0	0
LONP1	6	2	40	6	30
LRPPRC	7	7	68	8	2
MDH2	1	0	34	7	0
MRPL58	16	1	134	0	21
MTCH2	0	1	75	0	5
MYC	66	90	1269	2	0
NDUFB9	7	3	32	1	12
NDUFS1	6	3	51	2	9
NNT	0	0	10	1	0
P4HB	4	41	47	8	3
PDHA1	4	4	101	2	1
PHB1	2	7	130	1	0
PHB2	2	4	81	2	1
PPT1	1	4	25	1	0
PRKN	11	11	1405	0	0
PSMA3	22	53	89	13	0
PTPN5	0	8	15	0	0
RAF1	32	42	196	14	0
SFXN1	2	15	93	2	9
SLC19A2	4	3	13	1	9
SLC35F1	1	6	2	0	0
SPOP	9	29	86	0	2
SPRTN	0	0	46	0	0
STK4	23	17	947	24	7
TOMM22	3	5	31	1	21
TRIM63	8	10	36	0	0
TTN	7	13	31	0	0
TUFM	1	5	62	0	3
UNC93B1	4	24	61	0	22
UQCRC1	3	29	21	2	1
UQCRC2	2	6	42	0	1
VCP	57	56	348	43	5
VDAC1	9	15	77	22	2
VDAC2	8	21	62	8	0
VDAC3	3	3	32	12	0
WDR76	3	0	62	3	2
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CAPZB	100	6	133	666	0

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP5IF1	3	14	9	1	27
ATP5PB	14	15	31	0	53
ATP5PF	10	16	14	3	38
ATP6V0C	9	47	11	9	41
B4GALT3	1	0	2	0	33
CD27	2	5	4	0	31
F2RL1	5	8	7	0	62
GPR35	6	6	6	0	49
HTR1B	1	2	1	0	39
LHFPL4	0	1	0	0	17
P2RY1	0	1	0	0	25
PILRB	0	0	0	0	28
SCAMP2	4	2	7	13	43
TAS2R14	0	0	0	0	3
VIPR1	0	0	0	0	118
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene ATP5F1B is associated with 1 reactions in 1 different subsystems, and present in the compartments: Inner mitochondria, Mitochondria. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Oxidative phosphorylation	Mitochondria, Cytosol, Peroxisome, Endoplasmic reticulum, Inner mitochondria	106	16	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP5F1B-201	P06576	V9HW31	Enzymes Metabolic proteins Transporters Predicted intracellular proteins Plasma proteins Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	529 aa 56.6 kDa	No	0
ATP5F1B-207		F8W079	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	284 aa 30.2 kDa	No	0
ATP5F1B-209		H0YI37	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	133 aa 13.9 kDa	No	0
ATP5F1B-210		H0YH81	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	362 aa 38.1 kDa	No	0
ATP5F1B-211		F8W0P7	Metabolic proteins Predicted intracellular proteins Essential proteins Protein evidence (Ezkurdia et al 2014)	270 aa 28.4 kDa	No	0
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