Protein interactions - B4GALT3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	B4GALT3
Synonyms	beta4Gal-T3
Gene descriptionⁱ Full gene name according to HGNC.	Beta-1,4-galactosyltransferase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Plasma cells - Plasma cell differentiation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Esophageal apical cells, Extravillous trophoblasts, Migrating cytotrophoblasts, Plasma cells, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Protein processing (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Golgi apparatus In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	1
Cytoband	q23.3
Chromosome location (bp)	161171310 - 161177968
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3
Ensembl	ENSG00000158850 (version 109)
Entrez gene	8703
HGNC	HGNC:926
UniProt	O60512
GeneCards	B4GALT3

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Protein processing

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Category

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Pathway

Consensus

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BioGrid

OpenCell

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CANX	130	8	242	381	24

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Predicted location

Cell type specificity

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CANX	130	8	242	381	24
SLC19A2	4	3	13	1	9

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Subcell location

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ADAM21	0	2	0	0	22
ATP5F1A	9	8	71	2	11
ATP5F1B	10	14	76	1	15
ATP5IF1	3	14	9	1	27
ATP5MG	1	3	11	0	10
ATP5PB	14	15	31	0	53
ATP5PD	4	4	22	2	7
B4GAT1	1	1	3	3	37
C1orf54	0	0	0	0	37
CANX	130	8	242	381	24
CBLN4	0	0	0	0	60
CEACAM8	0	1	1	0	4
COA7	0	14	3	0	18
CST8	0	0	0	0	14
DNAJB9	1	1	3	0	60
DNASE1L1	1	11	1	0	58
ERLEC1	1	0	19	0	32
F2RL1	5	8	7	0	62
FAM8A1	2	1	5	0	17
GHITM	2	8	7	0	40
HSPD1	20	38	139	11	45
KDSR	1	3	5	3	19
LMF1	0	0	0	0	19
MT-ATP8	0	0	0	0	11
NTSR1	0	1	0	0	21
POMGNT1	2	7	5	0	25
PRG3	0	0	0	0	19
SEL1L	5	5	23	1	16
SFTPC	4	26	5	0	103
TMEM106A	1	8	1	0	107
TUBB8	2	1	3	1	96
UBE2J1	3	34	15	0	9
XYLT2	2	1	2	0	7
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene B4GALT3 is associated with 27 reactions in 5 different subsystems, and present in the compartments: Cytosol, Endoplasmic reticulum, Golgi apparatus. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Keratan sulfate biosynthesis	Golgi apparatus	22	70	20
Glycosphingolipid metabolism	Cytosol, Golgi apparatus, Lysosome, Endoplasmic reticulum, Nucleus, Extracellular	75	34	3
Glycosphingolipid biosynthesis-lacto and neolacto series	Cytosol	27	60	2
Sphingolipid metabolism	Cytosol, Golgi apparatus, Nucleus, Lysosome, Endoplasmic reticulum, Extracellular	130	109	1
N-glycan metabolism	Golgi apparatus, Endoplasmic reticulum, Lysosome, Extracellular, Cytosol	69	94	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
B4GALT3-201	O60512	A0A384NY44	Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	393 aa 43.9 kDa	No	0
B4GALT3-202	O60512	A0A384NY44	Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	393 aa 43.9 kDa	No	0
B4GALT3-213	O60512	A0A384NY44	Enzymes Metabolic proteins Predicted intracellular proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	393 aa 43.9 kDa	No	0