Protein interactions - HMOX2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HMOX2
Synonyms	HO-2
Gene descriptionⁱ Full gene name according to HGNC.	Heme oxygenase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Late spermatids - Spermiogenesis: Maturation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enriched (Late spermatids)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Mixed function (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Vesicles, Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	4474690 - 4510347
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17
Ensembl	ENSG00000103415 (version 109)
Entrez gene	3163
HGNC	HGNC:5014
UniProt	P30519
GeneCards	HMOX2

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Mixed function

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Cluster

Cell type

Category

Cluster

Pathway

Consensus

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OpenCell

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Interaction:

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CEP126	3	11	3	0	0
CKAP4	9	2	65	12	25
ELOVL5	3	13	8	1	0
GIT1	18	19	40	3	0
HAP1	5	27	17	0	0
PTPN1	13	27	77	1	18
SEC63	5	0	41	5	18
TAP1	5	17	9	0	24

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
APP	44	313	141	1	0
AQP6	0	264	0	0	0
ARL13B	2	109	13	1	2
BAAT	0	9	0	0	0
BCL2L13	2	43	6	0	0
C12orf4	1	7	1	0	0
CD79A	0	144	4	0	18
CEP126	3	11	3	0	0
COA7	0	14	3	0	18
EBP	0	159	3	1	1
ELL2	2	16	8	0	2
ELOVL4	0	79	0	0	0
ELOVL5	3	13	8	1	0
ERGIC3	7	187	11	0	0
FAM209A	0	200	0	0	0
FAM210B	0	55	0	0	3
FYN	21	51	69	0	0
GET1	1	27	1	2	1
GIT1	18	19	40	3	0
GPR152	0	164	0	0	0
GPX8	2	136	5	4	33
H3-5	0	17	7	0	0
HAP1	5	27	17	0	0
KCNJ6	0	51	1	0	0
LAPTM5	2	12	7	0	0
LRRC56	0	6	0	0	4
MGST3	1	79	7	0	20
NUP54	6	42	10	7	4
ODF3L2	0	10	1	0	3
POLR2I	14	4	26	24	8
RETREG3	10	91	13	0	35
RNASEK	0	22	0	0	0
SAR1A	1	66	5	0	2
SGPL1	1	29	6	13	20
SLC30A8	0	66	0	0	0
SNW1	48	89	129	19	25
SPSB1	4	19	8	0	1
SSMEM1	0	88	0	0	4
STOM	5	120	14	2	21
SYT1	2	16	10	0	7
TMEM14B	1	193	1	0	0
TMX2	3	131	3	4	0
UBE2A	3	17	28	2	1
VMA21	3	25	4	4	9
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Subcell location

Predicted location

Cell type specificity

Protein class

In same cell type

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP5F1B	10	14	76	1	15
CANX	130	8	242	381	24
CEP126	3	11	3	0	0
CKAP4	9	2	65	12	25
ELOVL5	3	13	8	1	0
GIT1	18	19	40	3	0
HAP1	5	27	17	0	0
KRAS	11	5	414	16	0
LMNA	17	54	239	32	3
LRRC59	5	14	90	13	0
NRAS	3	6	142	0	0
PTPN1	13	27	77	1	18
SEC63	5	0	41	5	18
TAP1	5	17	9	0	24
UNC93B1	4	24	61	0	22
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Subcell location

Predicted location

Cell type specificity

Protein class

In same cell type

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CABCOCO1	0	2	0	0	18
CCR1	3	5	3	0	224
CD27	2	5	4	0	31
CISD2	4	58	5	15	3
CKAP4	9	2	65	12	25
COL10A1	0	7	0	0	10
CYP2C18	0	0	0	0	13
ENDOD1	1	3	4	3	22
FAM234A	1	1	2	1	18
GGH	2	1	4	1	106
GP5	0	1	0	0	33
HLA-C	10	7	25	0	75
KIF18A	4	4	5	4	3
LDLRAD1	2	33	2	0	48
LPAR2	1	3	4	0	76
PI4K2A	0	1	4	2	3
PTPN1	13	27	77	1	18
SEC63	5	0	41	5	18
TAP1	5	17	9	0	24
TEX264	1	23	7	2	15
TMEM205	1	15	2	0	7
TSPAN15	2	4	3	0	122
UGT8	2	0	2	2	18
VAMP5	23	58	31	0	41
WIF1	0	4	0	0	87
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene HMOX2 is associated with 2 reactions in 2 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Porphyrin metabolism	Mitochondria, Cytosol, Extracellular, Nucleus	22	41	1
Heme degradation	Cytosol, Endoplasmic reticulum	3	14	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HMOX2-201	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	316 aa 36 kDa	No	1
HMOX2-202	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	316 aa 36 kDa	No	1
HMOX2-203	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	316 aa 36 kDa	No	1
HMOX2-204	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	316 aa 36 kDa	No	1
HMOX2-205	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	316 aa 36 kDa	No	1
HMOX2-206		I3L159	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	229 aa 26.6 kDa	No	0
HMOX2-207		I3L1Y2	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	110 aa 12.8 kDa	No	0
HMOX2-208	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	316 aa 36 kDa	No	1
HMOX2-209		I3L276	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	110 aa 12.6 kDa	No	0
HMOX2-210		I3L4P8	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	130 aa 15.1 kDa	No	0
HMOX2-212		I3L1F5	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	238 aa 27.7 kDa	No	0
HMOX2-213	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	287 aa 32.8 kDa	No	1
HMOX2-214		I3L463	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	132 aa 15.3 kDa	No	0
HMOX2-215		A0A1B0GXH0	Metabolic proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)	131 aa 15.2 kDa	No	0
HMOX2-216		A0A087WT44	Metabolic proteins Predicted membrane proteins Protein evidence (Ezkurdia et al 2014)	370 aa 41.7 kDa	No	1
HMOX2-217	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	316 aa 36 kDa	No	1
HMOX2-218	P30519		Enzymes Metabolic proteins Predicted membrane proteins Plasma proteins Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	316 aa 36 kDa	No	1
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