Protein interactions - MGST3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MGST3
Synonyms	GST-III
Gene descriptionⁱ Full gene name according to HGNC.	Microsomal glutathione S-transferase 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Basic cellular functions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Epididymal principal cells, Extravillous trophoblasts, Migrating cytotrophoblasts, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cellular respiration (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	1
Cytoband	q24.1
Chromosome location (bp)	165631213 - 165661796
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6
Ensembl	ENSG00000143198 (version 109)
Entrez gene	4259
HGNC	HGNC:7064
UniProt	O14880
GeneCards	MGST3

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Cellular respiration

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

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Interaction:

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
TFAM	3	8	34	5	0

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AGPAT4	0	22	2	0	4
APOD	0	40	5	0	21
APOL2	0	26	1	0	0
AQP1	1	106	2	0	0
AQP10	0	17	0	0	0
AQP3	0	23	0	0	0
ARL6IP1	10	60	11	16	0
ARL6IP6	1	13	1	18	10
BET1	8	41	28	5	10
BMP10	0	51	0	0	0
C11orf24	0	7	0	0	0
C14orf180	0	38	0	0	0
C3orf52	2	57	2	0	43
CACNG1	0	15	0	0	0
CCNC	25	71	41	15	0
CDIPT	0	47	1	2	2
CLRN1	0	23	0	0	0
CREB3L1	4	163	5	0	0
CYBC1	0	51	0	1	3
ERG28	4	48	4	3	0
FAXDC2	0	28	0	0	0
FUNDC2	1	22	3	0	19
FXYD6	0	44	0	0	0
GIMAP1	0	40	0	0	0
GIMAP5	0	53	1	0	0
GPR152	0	164	0	0	0
GPX8	2	136	5	4	33
GRM2	1	20	4	0	0
HMOX2	8	44	15	0	25
ITGAM	0	34	1	0	2
LEMD1	0	12	0	0	0
LPAR3	0	46	0	0	0
LRP10	0	21	1	0	16
MIP	0	35	1	0	0
MRM1	5	35	13	0	38
MTIF3	0	62	0	0	2
NEU1	0	16	3	0	9
NINJ2	0	63	0	0	0
NKG7	0	39	0	0	0
NRM	0	50	0	0	1
NSG1	0	26	2	3	1
PAGE1	1	12	1	0	0
PLN	3	44	6	0	0
PLP2	0	58	0	0	1
PLPP4	0	29	0	0	0
SCD	1	36	2	13	1
SCN3B	3	94	4	0	27
SEC22B	15	46	27	15	25
SLC1A3	2	3	7	2	6
SLC2A5	1	8	3	0	0
SLC35A1	0	27	0	0	0
SLC39A9	0	30	8	0	0
SLC7A1	5	47	43	0	17
SMCO4	0	51	0	0	0
SNAP47	1	22	4	0	0
SNORC	0	20	0	0	0
STX3	6	34	24	12	0
STX7	25	37	60	30	0
STX8	18	58	25	16	27
SYS1	0	14	0	0	0
TFAM	3	8	34	5	0
TFRC	3	23	112	1	0
TMEM107	0	38	0	0	0
TMEM109	0	13	3	0	2
TMEM120B	1	47	2	1	3
TMEM140	0	44	0	0	0
TMEM229B	0	34	0	0	0
TMEM60	0	86	0	0	0
TMEM86B	0	92	0	0	0
TMX2	3	131	3	4	0
TSPAN12	1	21	1	0	0
TSPAN2	4	34	4	0	18
TSPAN33	0	23	0	0	24
UBIAD1	1	33	8	3	0
UNC50	0	29	0	0	0
VAMP3	25	46	38	62	23
VAMP4	11	36	15	13	0
YIF1A	5	66	5	5	0
ZFPL1	3	54	14	0	11
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP5F1C	2	2	44	1	0
BIRC6	0	5	21	1	18
DNAJC11	7	4	22	11	0
TFAM	3	8	34	5	0
TOMM22	3	5	31	1	21
TOMM40	10	2	38	11	26
VDAC2	8	21	62	8	0

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
APLNR	0	4	0	0	84
CGRRF1	0	26	1	0	6
EDNRA	0	2	3	0	22
EFNA2	0	1	0	0	32
GLMN	5	3	21	1	13
GP5	0	1	0	0	33
HAVCR2	0	3	0	0	4
IRF9	1	2	4	0	3
LPAR2	1	3	4	0	76
NCR3LG1	0	9	4	2	4
RAMP3	0	7	0	0	100
SGCA	0	6	1	0	63
SLC2A1	6	0	20	2	62
SSUH2	0	0	0	0	130
TMEM184A	0	0	0	0	48
TMEM72	0	9	0	0	23
TOR1A	4	8	7	3	9
TSPAN15	2	4	3	0	122
VAC14	19	83	25	1	12
WIF1	0	4	0	0	87
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene MGST3 is associated with 66 reactions in 7 different subsystems, and present in the compartments: Cytosol, Endoplasmic reticulum, Mitochondria, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Estrogen metabolism	Cytosol, Endoplasmic reticulum, Mitochondria, Peroxisome, Lysosome	68	48	24
Xenobiotics metabolism	Cytosol, Extracellular, Endoplasmic reticulum, Peroxisome	110	178	18
Prostaglandin biosynthesis	Cytosol, Endoplasmic reticulum	49	80	5
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	4
Eicosanoid metabolism	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Golgi apparatus, Nucleus	42	82	5
Phenylalanine, tyrosine and tryptophan biosynthesis	Cytosol, Endoplasmic reticulum, Mitochondria	133	182	7
Arachidonic acid metabolism	Cytosol, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Mitochondria, Golgi apparatus	107	88	3

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGST3-201		Q5VV89	Metabolic proteins Predicted membrane proteins Protein evidence (Ezkurdia et al 2014)	166 aa 18.4 kDa	No	3
MGST3-202	O14880	A0A024R8Z1	Enzymes Metabolic proteins Predicted membrane proteins Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	152 aa 16.5 kDa	No	4
MGST3-203		Q5VV89	Metabolic proteins Predicted membrane proteins Protein evidence (Ezkurdia et al 2014)	166 aa 18.4 kDa	No	3
MGST3-204		Q5VV87	Metabolic proteins Predicted membrane proteins Protein evidence (Ezkurdia et al 2014)	129 aa 14.4 kDa	No	3
MGST3-205	O14880	A0A024R8Z1	Enzymes Metabolic proteins Predicted membrane proteins Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	152 aa 16.5 kDa	No	4
MGST3-214		Q5VV89	Metabolic proteins Predicted membrane proteins Protein evidence (Ezkurdia et al 2014)	166 aa 18.4 kDa	No	3
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