Protein interactions - SLC2A1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC2A1
Synonyms	CSE, DYT18, DYT9, GLUT, GLUT-1, GLUT1, HTLVR
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 2 member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Syncytiotrophoblasts - Placental homeostasis & endocrine signal (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Esophageal apical cells, Extravillous trophoblasts, Migrating cytotrophoblasts, Müller glia, Ocular epithelial cells, Prostatic hillock cells, Retinal pigment epithelial cells, Syncytiotrophoblasts, Urothelial cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Esophagus - Basic cellular processes (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Placenta)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Plasma membrane In addition localized to the Centriolar satellite
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	1
Cytoband	p34.2
Chromosome location (bp)	42925353 - 42958893
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5
Ensembl	ENSG00000117394 (version 109)
Entrez gene	6513
HGNC	HGNC:11005
UniProt	P11166
GeneCards	SLC2A1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Esophagus - Basic cellular processes

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Predicted location

Cell type specificity

Protein class

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Interaction:

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP6AP1	8	1	13	11	16
ATP6V0A2	13	0	15	16	29
HSP90AB1	65	146	187	22	19
NUP205	1	1	23	6	11
RAB35	5	3	18	5	11
XPO1	25	7	129	29	10

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Subcell location

Predicted location

Cell type specificity

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP11C	1	1	7	4	0
ATP6AP1	8	1	13	11	16
ATP6V0A1	13	1	22	17	0
ATP6V0A2	13	0	15	16	29
CCNF	4	4	624	0	1
CD55	0	0	1	0	0
GIPC1	8	6	27	2	7
HSP90AB1	65	146	187	22	19
LAMTOR1	17	16	54	6	16
NUP205	1	1	23	6	11
PRNP	9	17	294	0	0
RAB35	5	3	18	5	11
RHOB	3	2	308	1	1
RPGRIP1	3	19	6	0	0
SNX27	7	2	41	7	0
STK4	23	17	947	24	7
TUBB4A	4	2	16	0	20
TXNIP	3	4	31	0	0
WWP1	5	7	51	1	0
XPO1	25	7	129	29	10
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Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
HSP90AB1	65	146	187	22	19
VAMP3	25	46	38	62	23

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AGPAT2	1	0	2	0	29
ARF5	2	2	11	10	8
ATP1A3	3	15	4	6	92
ATP6AP1	8	1	13	11	16
ATP6AP2	16	11	33	19	72
ATP6V0A2	13	0	15	16	29
ATP6V0D2	2	11	4	0	24
BRAT1	1	7	2	0	23
BTAF1	1	0	2	1	17
CAND1	7	7	78	0	6
CHCHD6	3	3	6	0	18
CIAO1	8	14	40	0	13
COQ8B	0	0	3	0	29
CTPS2	2	2	2	1	33
DHCR24	3	1	8	8	32
EARS2	0	0	4	0	17
ECPAS	7	8	39	13	24
EI24	0	8	1	5	17
FASTKD1	0	9	1	0	32
FIS1	3	22	9	0	6
GBF1	5	2	19	5	27
GCN1	1	1	25	1	14
GEMIN4	11	29	31	12	20
GPAT3	1	0	5	4	9
ICMT	0	7	0	0	6
INTS1	7	1	22	10	24
KDELR1	0	3	3	0	22
KDELR3	1	0	1	0	17
MGST3	1	79	7	0	20
MICOS13	0	7	3	0	4
MPDU1	0	1	0	0	13
MSH2	7	8	55	6	3
MTX2	5	4	14	3	21
NUP205	1	1	23	6	11
PDXDC1	1	0	9	0	26
PEX3	3	2	8	2	21
PGM3	0	0	5	0	9
PIK3R4	6	6	14	5	16
PLSCR1	10	44	16	0	11
RAB18	1	3	6	12	15
RAB29	2	4	2	5	34
RAB35	5	3	18	5	11
RARS2	0	0	1	0	19
SAMM50	4	4	24	1	19
SFXN2	1	5	3	0	30
SLC25A33	0	0	0	0	11
SLC25A4	2	3	12	0	40
SLC33A1	0	1	4	2	9
SLC7A1	5	47	43	0	17
SPG7	0	18	0	0	23
STX17	7	8	13	0	18
SYNJ2BP	0	22	7	0	26
TELO2	3	6	16	0	19
TFB2M	0	1	2	0	14
TIMMDC1	6	53	11	0	41
TMEM161A	2	3	3	0	14
TMEM43	2	13	9	9	26
TMEM70	0	2	2	0	12
TOMM22	3	5	31	1	21
TTI2	2	1	3	0	6
XPO1	25	7	129	29	10
XPOT	2	4	6	1	8
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene SLC2A1 is associated with 7 reactions in 1 different subsystems, and present in the compartments: Cytosol, Endoplasmic reticulum, Extracellular, Golgi apparatus. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	7

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC2A1-201		A6NL68	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	116 aa 12.9 kDa	No	3
SLC2A1-203	P11166		Metabolic proteins Transporters Predicted membrane proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	492 aa 54.1 kDa	No	>9
SLC2A1-204		A0A1W2PQ59	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	43 aa 4.8 kDa	No	0
SLC2A1-205		A0A0D9SG74	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	142 aa 15.2 kDa	No	4
SLC2A1-212		A0A6Q8PFI8	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	359 aa 39.5 kDa	No	9
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