Protein interactions - ATP1A3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATP1A3
Synonyms	DYT12
Gene descriptionⁱ Full gene name according to HGNC.	ATPase Na+/K+ transporting subunit alpha 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane, Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neuronal signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (Brain excitatory neurons, Brain inhibitory neurons, Other brain neurons)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Brain & retina - Neuronal signaling (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (Brain, Heart muscle, Retina)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	41966582 - 41997497
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6
Ensembl	ENSG00000105409 (version 109)
Entrez gene	478
HGNC	HGNC:801
UniProt	P13637
GeneCards	ATP1A3

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Brain & retina - Neuronal signaling

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Predicted location

Cell type specificity

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Interaction:

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP1A1	5	4	53	5	1
ATP1A2	1	0	6	0	4
ATP1B3	3	4	16	7	9

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Subcell location

Predicted location

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ASCL4	2	34	2	0	4
BOK	0	4	0	0	1
CAMK2A	7	53	18	0	7
ESRP1	2	28	2	0	0
EYA3	0	8	3	0	0
INCA1	9	205	10	0	0
NPFFR1	0	2	0	0	0
PNMA5	1	53	1	0	0
SKIL	2	18	10	1	0
SPIRE1	3	5	5	4	0
SYNC	1	9	2	1	0
TP53BP1	11	70	68	2	0
VAC14	19	83	25	1	12
ZBTB49	2	11	6	0	0
ZNF20	0	43	0	0	0
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Subcell location

Predicted location

Cell type specificity

Protein class

In same cell type

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATP1A1	5	4	53	5	1
ATP1A2	1	0	6	0	4
ATP1B3	3	4	16	7	9
PRNP	9	17	294	0	0

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Subcell location

Predicted location

Cell type specificity

Protein class

In same cell type

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CALD1	3	2	10	93	0
CANX	130	8	242	381	24
RAB11A	21	11	205	47	13
SLC7A5	1	1	14	5	0
VAMP3	25	46	38	62	23
ZYX	10	14	26	5	1

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Subcell location

Predicted location

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Protein class

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AGK	2	3	7	0	17
AGPAT2	1	0	2	0	29
ALG2	0	2	7	1	3
ARL4D	0	1	2	0	18
ARL5B	0	1	1	0	7
ASPH	4	1	13	10	49
ATP1A1	5	4	53	5	1
ATP1A2	1	0	6	0	4
ATP1B3	3	4	16	7	9
ATP4A	0	0	9	0	1
B3GNT3	0	1	0	0	40
C5AR1	0	0	2	0	39
CACNG4	0	0	0	0	28
CD83	0	1	0	0	11
CLEC4E	5	3	50	0	43
CST9L	0	6	0	0	19
DHCR24	3	1	8	8	32
DIO3	0	0	0	0	12
DKKL1	0	0	0	0	42
DTWD2	0	0	0	0	5
EDNRA	0	2	3	0	22
EFNA2	0	1	0	0	32
EI24	0	8	1	5	17
ENTPD7	0	0	0	0	15
F2RL1	5	8	7	0	62
FA2H	0	25	1	0	8
FAM162A	1	2	4	2	7
FAM174A	1	31	2	0	98
FPR2	0	5	0	0	53
GP5	0	1	0	0	33
GPAT4	1	1	2	2	29
GPBAR1	0	1	0	0	22
GPR173	0	1	0	0	33
GPR182	1	1	1	0	243
GPR35	6	6	6	0	49
GPR45	0	0	0	0	197
GPR55	0	0	0	0	48
GZMH	0	0	0	0	53
HLA-DMB	1	2	1	0	28
HLA-DRB5	0	1	0	0	10
ICAM2	0	0	2	0	31
IRF3	6	12	29	0	5
KCNMB2	0	2	0	0	5
KLK5	0	2	0	0	46
LAGE3	7	20	11	0	25
LDLRAD1	2	33	2	0	48
LHFPL4	0	1	0	0	17
LRRC25	0	30	1	0	59
LRRN4CL	0	0	0	0	42
MELTF	0	1	0	0	27
MFSD4A	9	0	13	0	146
MGARP	1	14	2	0	115
MPDU1	0	1	0	0	13
MRGPRX4	0	0	0	0	4
NTSR1	0	1	0	0	21
P2RX1	0	1	0	0	3
P2RY2	0	1	1	0	64
P2RY8	0	0	0	0	105
PACC1	1	5	1	1	6
PRND	0	0	0	0	4
PROKR1	0	0	0	0	13
PTAFR	2	2	4	0	18
PVRIG	0	1	0	0	6
RAMP3	0	7	0	0	100
RER1	1	2	3	42	26
S1PR1	0	1	3	0	52
S1PR4	0	1	0	0	86
SEC22B	15	46	27	15	25
SFXN5	2	8	2	0	2
SGCA	0	6	1	0	63
SH2D3A	2	1	2	0	49
SHISAL1	0	24	0	0	19
SIGLECL1	1	3	1	0	17
SLC25A22	0	0	9	0	8
SLC2A1	6	0	20	2	62
SPN	1	6	3	0	21
ST3GAL1	1	0	1	0	2
STK16	1	67	3	0	31
TACR1	0	2	1	0	11
THTPA	0	1	0	0	30
TMEM231	5	8	9	0	14
TMEM72	0	9	0	0	23
TMEM9	5	11	10	0	81
TMEM9B	4	1	7	0	53
TMPRSS11B	5	0	57	0	16
TNFRSF10C	0	23	0	0	18
TNFRSF9	0	1	4	0	12
TNFSF8	0	2	0	0	80
TPST2	0	0	2	0	42
TREML1	0	1	0	0	3
TSPAN15	2	4	3	0	122
UPK2	0	20	0	0	51
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene ATP1A3 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol, Extracellular. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP1A3-204		M0QXF2	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	251 aa 27.3 kDa	No	2
ATP1A3-206	P13637		Enzymes Metabolic proteins Transporters Predicted membrane proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1024 aa 113.1 kDa	No	>9
ATP1A3-207	P13637		Enzymes Metabolic proteins Transporters Predicted membrane proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1026 aa 113.1 kDa	No	>9
ATP1A3-208		M0R116	Metabolic proteins Predicted membrane proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	983 aa 108.3 kDa	No	>9
ATP1A3-209			Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	1 aa 0.1 kDa	No	0
ATP1A3-214	P13637		Enzymes Metabolic proteins Transporters Predicted membrane proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1013 aa 111.7 kDa	No	>9
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