Protein interactions - HADHA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HADHA
Synonyms	GBP, LCEH, LCHAD, MTPA
Gene descriptionⁱ Full gene name according to HGNC.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Colonocytes & Enterocytes - Gastrointestinal absorption & barrier (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Enterocytes)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cellular respiration (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Skeletal muscle)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	26190635 - 26244672
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3
Ensembl	ENSG00000084754 (version 109)
Entrez gene	3030
HGNC	HGNC:4801
UniProt	P40939
GeneCards	HADHA

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Cellular respiration

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CD74	3	8	8	0	0
CSNK2A2	56	8	149	232	22
HADHB	1	2	31	3	5
MAP1LC3B	31	57	83	6	0

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CD74	3	8	8	0	0
GABARAP	19	41	44	0	1
GABARAPL1	23	60	44	1	1
GABARAPL2	23	76	35	1	1
HADHB	1	2	31	3	5
HTT	36	666	56	0	0
MAP1LC3B	31	57	83	6	0
NDUFAB1	3	30	10	1	16
TRAF6	31	60	155	0	3

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AAR2	19	1	36	9	21
AGR2	3	64	227	0	2
ANLN	1	0	568	2	0
ATP5MG	1	3	11	0	10
BAP1	9	7	117	0	6
C17orf80	0	2	8	6	0
CANX	130	8	242	381	24
CD74	3	8	8	0	0
CLPP	2	19	211	0	5
COX4I1	2	5	105	2	1
COX8A	1	4	4	0	0
CS	0	0	186	4	0
CSNK2A2	56	8	149	232	22
FGFR3	4	191	23	0	0
GNA11	1	2	6	3	9
GRSF1	2	1	170	2	0
H4C1	32	56	356	0	5
HADHB	1	2	31	3	5
IFITM1	0	0	29	0	7
IFITM3	6	22	54	0	34
LRPPRC	7	7	68	8	2
MAP1B	4	3	48	7	2
MAP1LC3A	8	16	70	1	0
MAP1LC3B	31	57	83	6	0
MECOM	3	4	58	2	0
MINK1	1	5	29	7	0
MRPL58	16	1	134	0	21
MYC	66	90	1269	2	0
NIPSNAP2	3	5	26	0	3
NTRK3	8	11	40	0	0
PDHA1	4	4	101	2	1
PDPK1	4	7	42	1	0
PHB1	2	7	130	1	0
PPM1G	17	4	37	43	7
PRKCZ	10	14	74	0	7
PRKN	11	11	1405	0	0
PRPF8	33	22	165	18	14
RAF1	32	42	196	14	0
RPS19	53	8	112	44	127
SQSTM1	32	40	312	2	0
TFAM	3	8	34	5	0
TOMM40	10	2	38	11	26
TPTE	0	0	30	0	0
TUBA1A	12	9	90	0	121
TUBB4B	14	1	52	93	13
UBC	35	59	463	4	0
UBE2O	22	7	74	12	29
VDAC1	9	15	77	22	2
WWOX	4	7	65	1	1
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CAPZB	100	6	133	666	0
CSNK2A2	56	8	149	232	22
DDB1	39	22	173	64	9
SRP9	9	5	11	242	0

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
B3GALT6	0	0	1	0	4
CCDC50	0	6	8	0	5
GPC1	2	0	9	1	20
GPC4	3	2	8	4	6
HADHB	1	2	31	3	5
IPO9	5	3	13	7	16
LGALS1	4	11	20	5	49
SDC1	1	3	7	0	7
SDC2	1	9	11	0	34
SDC4	0	6	4	0	7

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene HADHA is associated with 259 reactions in 21 different subsystems, and present in the compartments: Cytosol, Mitochondria, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Beta oxidation of odd-chain fatty acids (mitochondrial)	Mitochondria	11	47	26
Beta oxidation of even-chain fatty acids (mitochondrial)	Mitochondria	14	66	48
Beta oxidation of poly-unsaturated fatty acids (mitochondrial)	Mitochondria	8	34	14
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	70	358	37
Arachidonic acid metabolism	Cytosol, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Mitochondria, Golgi apparatus	107	88	6
Vitamin E metabolism	Mitochondria, Cytosol, Endoplasmic reticulum	55	68	13
Beta oxidation of branched-chain fatty acids (mitochondrial)	Mitochondria	9	23	8
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	38	56	11
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)	Peroxisome	9	47	11
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)	Mitochondria	12	30	15
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	19
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)	Mitochondria	12	26	12
Beta oxidation of even-chain fatty acids (peroxisomal)	Peroxisome	9	59	12
Beta oxidation of phytanic acid (peroxisomal)	Peroxisome, Cytosol	13	37	3
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)	Mitochondria	13	28	12
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)	Peroxisome	9	17	2
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)	Peroxisome	9	28	6
Drug metabolism	Cytosol, Mitochondria, Peroxisome, Extracellular, Endoplasmic reticulum	55	210	1
Valine, leucine, and isoleucine metabolism	Mitochondria, Cytosol, Peroxisome	68	71	1
Omega-3 fatty acid metabolism	Cytosol, Peroxisome, Nucleus, Endoplasmic reticulum	52	73	1
Tryptophan metabolism	Mitochondria, Cytosol	21	39	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HADHA-201	P40939	E9KL44	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	763 aa 83 kDa	No	0
HADHA-204		H0YFD6	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	792 aa 86.4 kDa	No	0
HADHA-209		A0A2R8Y4F5	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	728 aa 79.5 kDa	No	0