Protein interactions - HADHB - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HADHB
Synonyms	MTPB
Gene descriptionⁱ Full gene name according to HGNC.	Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Myocytes - Oxidative muscle function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cardiomyocytes, Enterocytes, Esophageal apical cells, Thymic myoid cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Cellular respiration (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Heart muscle, Skeletal muscle, Tongue)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria In addition localized to the Equatorial segment, Principal piece
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	2
Cytoband	p23.3
Chromosome location (bp)	26243170 - 26290465
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7
Ensembl	ENSG00000138029 (version 109)
Entrez gene	3032
HGNC	HGNC:4803
UniProt	P55084
GeneCards	HADHB

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Cellular respiration

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
HADHA	4	9	49	4	10

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
GABARAPL1	23	60	44	1	1
HADHA	4	9	49	4	10

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACE2	10	13	278	0	0
ALK	1	5	103	0	0
ANLN	1	0	568	2	0
ATP1A1	5	4	53	5	1
C17orf80	0	2	8	6	0
CANX	130	8	242	381	24
CSNK2A2	56	8	149	232	22
DDOST	26	6	54	108	0
DDR2	5	6	26	0	0
EMC2	17	9	49	18	20
FGFR1	12	13	68	0	0
FGFR3	4	191	23	0	0
FGFR4	3	3	22	0	0
GNB2	24	26	48	0	63
HADHA	4	9	49	4	10
IFITM1	0	0	29	0	7
IFITM3	6	22	54	0	34
MINK1	1	5	29	7	0
MYC	66	90	1269	2	0
NIPSNAP2	3	5	26	0	3
PDPK1	4	7	42	1	0
PRKCZ	10	14	74	0	7
PRKN	11	11	1405	0	0
PRNP	9	17	294	0	0
RAF1	32	42	196	14	0
SQSTM1	32	40	312	2	0
TPTE	0	0	30	0	0
UBC	35	59	463	4	0
UBE2O	22	7	74	12	29
UQCRC2	2	6	42	0	1
VDAC1	9	15	77	22	2
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CAPZB	100	6	133	666	0
DDB1	39	22	173	64	9
SRP9	9	5	11	242	0

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
GPC1	2	0	9	1	20
HADHA	4	9	49	4	10
IPO9	5	3	13	7	16
LGALS1	4	11	20	5	49
SDC2	1	9	11	0	34

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene HADHB is associated with 115 reactions in 15 different subsystems, and present in the compartments: Cytosol, Mitochondria. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Beta oxidation of even-chain fatty acids (mitochondrial)	Mitochondria	14	66	30
Vitamin E metabolism	Mitochondria, Cytosol, Endoplasmic reticulum	55	68	13
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial)	Mitochondria	13	28	4
Valine, leucine, and isoleucine metabolism	Mitochondria, Cytosol, Peroxisome	68	71	1
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	70	358	27
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	38	56	1
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial)	Mitochondria	12	30	5
Beta oxidation of odd-chain fatty acids (mitochondrial)	Mitochondria	11	47	9
Arachidonic acid metabolism	Cytosol, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Mitochondria, Golgi apparatus	107	88	6
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial)	Mitochondria	12	26	4
Beta oxidation of poly-unsaturated fatty acids (mitochondrial)	Mitochondria	8	34	6
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	4
Beta oxidation of branched-chain fatty acids (mitochondrial)	Mitochondria	9	23	3
Drug metabolism	Cytosol, Mitochondria, Peroxisome, Extracellular, Endoplasmic reticulum	55	210	1
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HADHB-201	P55084		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	474 aa 51.3 kDa	No	0
HADHB-202		B5MD38	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	351 aa 37.9 kDa	No	0
HADHB-203		C9K0M0	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	84 aa 9.3 kDa	No	0
HADHB-204		C9JE81	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	175 aa 18.7 kDa	No	0
HADHB-205		C9JEY0	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	149 aa 16.1 kDa	No	0
HADHB-208		F5GZQ3	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	459 aa 49.6 kDa	No	0
HADHB-209	P55084		Enzymes Metabolic proteins Predicted intracellular proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	452 aa 48.9 kDa	No	0
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