On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.
h
m
l
n
Glandular cells:
Not detected
Lymphoid tissue:
Medium
RNA expressioni
A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.
Scroll down to view mRNA expression data in more detail.
Consensus:
0.4
nTPM
HPA:
0.4
nTPM
FANTOM5:
1.8
Scaled Tags Per Million
APPENDIX - Antibody stainingi
Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.
Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.
Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)
Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts
Antibody HPA013191
Glandular cells
Not detected
Lymphoid tissue
High
APPENDIX - PROTEINTALKS DB MS
Median intensity
ND
Sample
Intensity
Appendix_01
ND
Appendix_02
ND
APPENDIX - HPA RNA-seqi
The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.
Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.
Average nTPMi
Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.
0.4
Male, age 26
Appendix sample 92 nTPM: 0.4
Cell types%
Lymphocytes:
70
Fibroblasts:
15
Smooth muscle cells:
5
Endothelial cells:
5
Other cell types:
5
Female, age 37
Appendix sample 93 nTPM: 0.5
Cell types%
Lymphocytes:
65
Fibroblasts:
15
Smooth muscle cells:
10
Endothelial cells:
5
Other cell types:
5
Female, age 53
Appendix sample 94 nTPM: 0.2
Cell types%
Lymphocytes:
75
Fibroblasts:
5
Smooth muscle cells:
5
Endothelial cells:
5
Other cell types:
10
APPENDIX - FANTOM5 CAGEi
RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.
Max subtype Scaled Tags Per Millioni
Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.
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The Human Protein Atlas project is funded
