Protein interactions - EHHADH - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EHHADH
Synonyms	ECHD
Gene descriptionⁱ Full gene name according to HGNC.	Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Proximal tubular cells - Transmembrane transport (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Adipocytes, Hepatocytes, Proximal tubule cells, Retinal pigment epithelial cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Liver & Kidney - Metabolism (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (Kidney, Liver)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Not available
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	3
Cytoband	q27.2
Chromosome location (bp)	185190624 - 185281990
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3
Ensembl	ENSG00000113790 (version 109)
Entrez gene	1962
HGNC	HGNC:3247
UniProt	Q08426
GeneCards	EHHADH

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Liver & Kidney - Metabolism

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
KCTD6	2	20	7	0	11
TRIM41	9	112	14	0	0
TRIM63	8	10	36	0	0
ZRANB1	35	112	197	0	1

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AARS2	2	1	26	0	6
ACTB	77	27	195	111	34
ACTG1	30	15	75	116	0
ARMCX3	3	3	5	2	4
BHLHE40	2	52	8	0	0
C1orf50	1	11	1	1	0
CBS	1	17	4	0	0
CCDC102B	3	87	3	0	0
CCDC13	0	37	0	0	0
CDR2L	9	49	11	0	11
CFL2	4	11	9	4	1
CISD2	4	58	5	15	3
CLDN18	0	2	0	0	0
CLDN5	0	33	0	0	0
CLK2	15	45	40	2	0
CMTM6	2	17	4	0	34
COQ9	6	32	6	0	2
CYB561	0	49	0	0	0
CYB561A3	0	21	0	0	0
DERL3	0	14	0	0	0
DES	11	36	17	0	15
DIABLO	8	25	24	3	0
EBP	0	159	3	1	1
EMP1	0	55	0	0	0
ERGIC1	1	4	9	0	0
ERGIC3	7	187	11	0	0
ERVFRD-1	0	21	0	0	0
FUNDC1	0	13	5	0	2
GAS8	1	97	1	0	0
GMCL1	5	50	9	0	4
GRIPAP1	4	48	6	0	4
HID1	1	9	1	0	0
HIP1	4	48	11	6	1
HMG20A	11	53	27	11	7
HSD17B11	5	55	10	4	5
IKZF3	4	131	22	0	0
JAGN1	1	102	4	3	0
KCTD6	2	20	7	0	11
KCTD9	4	77	8	0	4
KRTAP10-7	8	239	10	0	0
KRTAP4-11	0	61	1	0	0
LCN2	1	47	1	0	0
LEPROTL1	0	68	0	0	0
LTBR	5	6	7	0	4
LYPD5	0	8	0	0	0
LZTFL1	6	17	6	0	2
LZTS2	21	178	46	4	7
MAB21L3	0	24	0	0	0
MID1	9	27	26	0	0
NACC1	0	11	15	0	1
ORMDL1	0	31	0	1	1
PAQR8	0	3	0	0	0
PICK1	10	276	36	0	9
PNMA1	5	115	6	0	3
PNMA5	1	53	1	0	0
PPP1R12C	2	15	7	0	0
PRKRA	22	16	34	7	169
PRMT5	19	53	84	0	6
PSTPIP1	4	42	7	0	0
PTGES	0	15	0	0	0
RNF4	10	80	71	0	4
RPRM	1	66	1	0	0
RUSF1	2	49	4	0	22
SDR16C5	0	9	0	0	9
SFT2D1	0	27	0	0	0
SGCB	0	10	2	1	19
SLC14A2	0	9	2	0	0
SLC39A2	0	45	0	0	0
SMIM5	0	7	0	0	0
SMN1	26	67	71	20	0
SMN2	6	67	13	0	0
SSMEM1	0	88	0	0	4
SSNA1	3	12	3	0	1
SSX2IP	9	81	32	3	0
SYNGR3	0	15	2	0	0
TMEM121	0	12	0	0	0
TMEM17	1	4	1	0	0
TMEM35A	0	22	0	0	0
TNIP1	22	68	77	0	0
TPP2	0	3	3	7	9
TRAF1	17	168	46	0	9
TRAF2	53	240	125	2	0
TRIM21	3	24	107	0	0
TRIM23	9	142	23	0	0
TRIM27	20	235	63	0	0
TRIM41	9	112	14	0	0
TRIM54	3	151	8	0	0
TRIM63	8	10	36	0	0
VAC14	19	83	25	1	12
ZBTB26	0	27	0	0	0
ZBTB8A	2	58	5	0	0
ZBTB9	1	29	3	0	4
ZCCHC17	2	13	6	8	0
ZRANB1	35	112	197	0	1
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CAT	0	1	20	0	0
KCTD6	2	20	7	0	11
PEX5	3	11	34	0	0
TRIM41	9	112	14	0	0
TRIM63	8	10	36	0	0
ZRANB1	35	112	197	0	1

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Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
KCTD6	2	20	7	0	11

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene EHHADH is associated with 168 reactions in 13 different subsystems, and present in the compartments: Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	70	358	70
Beta oxidation of even-chain fatty acids (peroxisomal)	Peroxisome	9	59	24
Beta-alanine metabolism	Cytosol, Mitochondria, Peroxisome	20	31	1
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	13
Omega-3 fatty acid metabolism	Cytosol, Peroxisome, Nucleus, Endoplasmic reticulum	52	73	2
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	38	56	9
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)	Peroxisome	9	47	20
Bile acid biosynthesis	Peroxisome, Endoplasmic reticulum, Cytosol, Mitochondria, Extracellular	94	171	4
Drug metabolism	Cytosol, Mitochondria, Peroxisome, Extracellular, Endoplasmic reticulum	55	210	3
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)	Peroxisome	9	28	10
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)	Peroxisome	9	17	4
Beta oxidation of phytanic acid (peroxisomal)	Peroxisome, Cytosol	13	37	6
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Golgi apparatus	524	320	2

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EHHADH-201	Q08426		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	723 aa 79.5 kDa	No	0
EHHADH-202		C9JJE0	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	76 aa 8.3 kDa	No	0
EHHADH-203	Q08426		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	627 aa 69.2 kDa	No	0