Protein interactions - NCOA3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NCOA3
Synonyms	ACTR, AIB1, bHLHe42, CAGH16, KAT13B, p/CIP, RAC3, SRC-3, SRC3, TNRC16, TRAM-1
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear receptor coactivator 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes Metabolic proteins Plasma proteins Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	B-cells - Adaptive immunity: Humoral response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (B-cells, Endometrial glandular cells, Plasma cells)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Lymphoid tissue - Immune response (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	47501887 - 47656877
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3
Ensembl	ENSG00000124151 (version 109)
Entrez gene	8202
HGNC	HGNC:7670
UniProt	Q9Y6Q9
GeneCards	NCOA3

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Lymphoid tissue - Immune response

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CARM1	6	10	44	3	0
EP300	27	34	372	4	1
ESR1	34	59	479	0	0
PSMB9	3	7	29	0	0
PSME3	34	35	72	43	0
RARA	15	28	61	0	0
SPOP	9	29	86	0	2

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ATAD2	1	2	10	4	0
CARM1	6	10	44	3	0
EP300	27	34	372	4	1
ESR1	34	59	479	0	0
PSMB9	3	7	29	0	0
PSME3	34	35	72	43	0
RAB28	1	6	1	0	0
RARA	15	28	61	0	0
SPOP	9	29	86	0	2

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ABL1	26	34	95	7	0
ANKRD11	0	0	15	2	2
AR	34	42	254	0	0
BRCA1	36	39	311	3	0
CARM1	6	10	44	3	0
CHUK	13	19	67	7	14
CREBBP	21	36	199	4	0
CSNK1E	18	18	52	4	16
CTDSPL2	3	2	13	2	2
E2F1	10	20	75	0	0
EP300	27	34	372	4	1
ESR1	34	59	479	0	0
ESR2	2	6	60	0	0
ESRRA	3	7	12	0	0
ETV1	2	4	6	0	0
FOS	9	48	49	0	16
H3-4	6	22	109	0	0
H4C16	8	56	21	19	5
HNF1A	0	0	13	0	0
IKBKB	15	23	81	6	6
IKBKG	44	62	98	5	0
KAT2B	11	12	115	5	1
MAPK1	19	34	123	5	12
MAPK14	24	27	66	4	0
MMS19	10	8	34	0	12
MYOCD	1	2	5	0	0
NCOA2	4	5	30	1	0
NCOR1	13	18	94	3	0
NCOR2	9	15	75	1	0
NFIA	16	32	103	0	0
NFIB	12	25	84	0	0
NFIC	9	10	116	1	0
NKX2-1	0	1	13	0	0
NR3C1	4	10	104	3	1
NSD2	7	4	35	14	17
PGR	2	3	25	0	0
PHF1	1	45	30	0	0
PIN1	16	116	59	0	2
PPARD	1	3	14	0	0
PPARG	7	13	79	0	0
PRKCZ	10	14	74	0	7
PSMB9	3	7	29	0	0
PSMC5	39	31	121	19	25
PSME3	34	35	72	43	0
RARA	15	28	61	0	0
RXRA	10	13	50	0	0
SMAD2	17	23	69	0	0
SOX2	5	8	201	0	0
SPOP	9	29	86	0	2
THRB	0	0	18	0	0
TP53BP1	11	70	68	2	0
TRIM21	3	24	107	0	0
VDR	7	12	42	0	0
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
MIF	2	4	15	91	0

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene NCOA3 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Golgi apparatus	524	320	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCOA3-201	Q9Y6Q9		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Transcription factors Cancer-related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1415 aa 154.4 kDa	No	0
NCOA3-202	Q9Y6Q9		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Transcription factors Cancer-related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1424 aa 155.3 kDa	No	0
NCOA3-203	Q9Y6Q9		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Transcription factors Cancer-related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	1420 aa 154.9 kDa	No	0