Protein interactions - HSD17B4 - The Human Protein Atlas

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HSD17B4

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Field

Cluster

Cell type

Category

Cluster

Cluster

Pathway

SUMMARY

TISSUE

BRAIN

SINGLE CELL

SUBCELL

CANCER

BLOOD

CELL LINE

STRUCTURE

INTERACTION

HSD17B4

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HSD17B4
Synonyms	DBP, MFE-2, SDR8C1
Gene descriptionⁱ Full gene name according to HGNC.	Hydroxysteroid 17-beta dehydrogenase 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Alveolar cells - Lung function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Alveolar cells type 2, Hepatocytes)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Metabolism (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Liver)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Peroxisomes
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	5
Cytoband	q23.1
Chromosome location (bp)	119452465 - 119637199
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10
Ensembl	ENSG00000133835 (version 109)
Entrez gene	3295
HGNC	HGNC:5213
UniProt	P51659
GeneCards	HSD17B4

ASSAYSⁱ

INTERACTIONⁱ

e.g. Brain enriched, Localized to mitochondria, Non-specific - Metabolism

Field

Cluster

Cell type

Category

Cluster

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AGPS	1	1	11	3	0
CAT	0	1	20	0	0
CDK7	16	6	48	17	9
LTK	1	2	34	0	0
PEX14	4	7	18	5	0
PEX5	3	11	34	0	0
PRKN	11	11	1405	0	0
SCP2	1	2	3	0	0
STAU1	32	13	371	39	0
TUBA1A	12	9	90	0	121

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene HSD17B4 is associated with 125 reactions in 14 different subsystems, and present in the compartments: Cytosol, Endoplasmic reticulum, Mitochondria, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Fatty acid oxidation	Cytosol, Endoplasmic reticulum, Peroxisome, Mitochondria, Extracellular	70	358	57
Vitamin E metabolism	Mitochondria, Cytosol, Endoplasmic reticulum	55	68	13
Beta oxidation of even-chain fatty acids (peroxisomal)	Peroxisome	9	59	12
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal)	Peroxisome	9	47	9
Bile acid biosynthesis	Peroxisome, Endoplasmic reticulum, Cytosol, Mitochondria, Extracellular	94	171	5
Arachidonic acid metabolism	Cytosol, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Mitochondria, Golgi apparatus	107	88	6
Omega-6 fatty acid metabolism	Cytosol, Mitochondria, Peroxisome	38	56	3
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal)	Peroxisome	9	28	4
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	6
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal)	Peroxisome	9	17	2
Beta oxidation of phytanic acid (peroxisomal)	Peroxisome, Cytosol	13	37	3
Omega-3 fatty acid metabolism	Cytosol, Peroxisome, Nucleus, Endoplasmic reticulum	52	73	1
Drug metabolism	Cytosol, Mitochondria, Peroxisome, Extracellular, Endoplasmic reticulum	55	210	3
Cholesterol metabolism	Cytosol, Peroxisome, Mitochondria, Lysosome, Endoplasmic reticulum, Nucleus	31	66	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HSD17B4-201	P51659		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	761 aa 83 kDa	No	0
HSD17B4-208		E7EPL9	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	713 aa 77.1 kDa	No	0
HSD17B4-211	P51659	A0A0S2Z4J1	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	736 aa 79.7 kDa	No	0
HSD17B4-216		E7ET17	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	599 aa 65 kDa	No	0
HSD17B4-218	P51659		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	718 aa 77.9 kDa	No	0
HSD17B4-219		A0A804HIR1	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	484 aa 52 kDa	No	0
HSD17B4-227		A0A2R8Y7L2	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	589 aa 63.7 kDa	No	0
HSD17B4-230		A0A2R8YD50	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	711 aa 76.8 kDa	No	0
HSD17B4-233		A0A2R8YDT8	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	166 aa 17.8 kDa	No	0
HSD17B4-239		A0A804HK65	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	712 aa 77.2 kDa	No	0
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