Protein interactions - ALDOA - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ALDOA
Synonyms
Gene descriptionⁱ Full gene name according to HGNC.	Aldolase, fructose-bisphosphate A
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Essential proteins Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Neurotransmission & signaling (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Astrocytes, Bergmann glia, Brain excitatory neurons, Brain inhibitory neurons, Choroid plexus epithelial cells, Ependymal cells, Microglia, Oligodendrocyte progenitor cells, Oligodendrocytes, Other brain neurons)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Skeletal muscle - Striated muscle contraction (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Group enriched (Skeletal muscle, Tongue)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	30064164 - 30070457
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13
Ensembl	ENSG00000149925 (version 109)
Entrez gene	226
HGNC	HGNC:414
UniProt	P04075
GeneCards	ALDOA

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Skeletal muscle - Striated muscle contraction

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ALDOB	5	5	5	0	0
ALDOC	1	3	2	1	1
PCNA	34	37	150	10	14

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ALDOB	5	5	5	0	0
ALDOC	1	3	2	1	1
CARM1	6	10	44	3	0
EGFR	187	275	458	0	6
PCNA	34	37	150	10	14

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACE2	10	13	278	0	0
ADRB2	7	18	63	0	0
AGR2	3	64	227	0	2
ALDOB	5	5	5	0	0
ALDOC	1	3	2	1	1
ATG5	11	18	33	2	9
CCNF	4	4	624	0	1
CDK2	29	26	141	10	24
CFTR	34	103	236	0	0
CKB	3	5	20	3	1
CUL3	40	45	771	2	0
DDX39B	24	15	110	44	0
ENO1	5	6	78	5	1
ENO3	1	1	8	1	0
FKBP2	1	5	5	0	4
GAPDH	9	29	97	12	1
HSD17B10	5	5	44	3	0
HSPA1A	1	7	318	0	0
ISG15	3	6	73	0	2
METTL14	1	1	31	0	0
PCNA	34	37	150	10	14
PGK1	4	5	32	5	1
PLD2	0	4	17	1	0
PRKN	11	11	1405	0	0
SOD1	5	51	62	0	1
SUMO2	14	18	107	0	0
TALDO1	0	2	10	1	0
TPI1	0	4	28	0	0
UBXN7	9	22	32	2	1
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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CAPZB	100	6	133	666	0

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ALDOC	1	3	2	1	1
RPS4Y1	1	0	3	0	27

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene ALDOA is associated with 4 reactions in 4 different subsystems, and present in the compartments: Cytosol. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Fructose and mannose metabolism	Cytosol	32	33	1
Glycolysis / Gluconeogenesis	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Nucleus	73	59	1
Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism	Cytosol, Mitochondria, Peroxisome	47	45	1
Galactose metabolism	Extracellular, Cytosol, Lysosome, Golgi apparatus, Nucleus	26	32	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDOA-201		J3KPS3	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	368 aa 39.8 kDa	No	0
ALDOA-202	P04075	V9HWN7	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	364 aa 39.4 kDa	No	0
ALDOA-203		H3BR04	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	162 aa 17.8 kDa	No	0
ALDOA-205		H3BPS8	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	278 aa 30.4 kDa	No	0
ALDOA-206	P04075	V9HWN7	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	364 aa 39.4 kDa	No	0
ALDOA-207		H3BUH7	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	155 aa 16.9 kDa	No	0
ALDOA-209		H3BU78	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	204 aa 22.1 kDa	No	0
ALDOA-210		H3BR68	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	130 aa 13.7 kDa	No	0
ALDOA-214		H3BMQ8	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	140 aa 15.5 kDa	No	0
ALDOA-216	P04075	V9HWN7	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	364 aa 39.4 kDa	No	0
ALDOA-217		H3BQN4	Metabolic proteins Predicted intracellular proteins Human disease related genes Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	361 aa 39.3 kDa	No	0
ALDOA-218	P04075		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Essential proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	418 aa 45.3 kDa	No	0
ALDOA-219	P04075	V9HWN7	Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	364 aa 39.4 kDa	No	0
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