Protein interactions - ALDH7A1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ALDH7A1
Synonyms	ATQ1, EPD, PDE
Gene descriptionⁱ Full gene name according to HGNC.	Aldehyde dehydrogenase 7 family member A1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Cytotrophoblasts - Basic cellular functions (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Migrating cytotrophoblasts, Ovarian stromal cells, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Brain & Liver - Signaling (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Liver)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria In addition localized to the Cytosol
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	5
Cytoband	q23.2
Chromosome location (bp)	126531200 - 126595362
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13
Ensembl	ENSG00000164904 (version 109)
Entrez gene	501
HGNC	HGNC:877
UniProt	P49419
GeneCards	ALDH7A1

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Brain & Liver - Signaling

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
EPS8	5	14	12	0	10

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
EPS8	5	14	12	0	10

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ABAT	0	0	6	0	0
BSG	4	5	87	8	0
EPS8	5	14	12	0	10

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CD2BP2	33	24	43	43	16
COPA	14	2	40	78	0
COPB2	13	1	29	122	4
COPE	19	3	28	92	13

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene ALDH7A1 is associated with 34 reactions in 17 different subsystems, and present in the compartments: Cytosol, Endoplasmic reticulum, Mitochondria, Peroxisome. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Pyruvate metabolism	Cytosol, Mitochondria	47	38	3
Tricarboxylic acid cycle and glyoxylate/dicarboxylate metabolism	Cytosol, Mitochondria, Peroxisome	47	45	2
Leukotriene metabolism	Peroxisome, Mitochondria, Cytosol, Endoplasmic reticulum, Nucleus, Extracellular	199	105	4
Glycine, serine and threonine metabolism	Cytosol, Mitochondria, Peroxisome	59	92	3
Isolated	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Extracellular, Nucleus, Golgi apparatus	524	320	2
Ascorbate and aldarate metabolism	Cytosol, Endoplasmic reticulum	10	30	1
Lysine metabolism	Cytosol, Nucleus, Endoplasmic reticulum, Peroxisome, Mitochondria	49	63	2
Arginine and proline metabolism	Cytosol, Mitochondria, Extracellular, Peroxisome, Endoplasmic reticulum	58	93	2
Glycolysis / Gluconeogenesis	Cytosol, Mitochondria, Peroxisome, Endoplasmic reticulum, Nucleus	73	59	1
Histidine metabolism	Cytosol, Mitochondria	56	41	2
Beta-alanine metabolism	Cytosol, Mitochondria, Peroxisome	20	31	3
Valine, leucine, and isoleucine metabolism	Mitochondria, Cytosol, Peroxisome	68	71	2
Glycerolipid metabolism	Cytosol, Lysosome, Endoplasmic reticulum, Extracellular, Mitochondria	65	154	2
Bile acid biosynthesis	Peroxisome, Endoplasmic reticulum, Cytosol, Mitochondria, Extracellular	94	171	2
Tryptophan metabolism	Mitochondria, Cytosol	21	39	1
Phenylalanine, tyrosine and tryptophan biosynthesis	Cytosol, Endoplasmic reticulum, Mitochondria	133	182	1
Serotonin and melatonin biosynthesis	Cytosol	54	40	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ALDH7A1-201	P49419		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	539 aa 58.5 kDa	No	0
ALDH7A1-203		A0A0J9YWF7	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	294 aa 32.1 kDa	No	0
ALDH7A1-211		F8VVF2	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	193 aa 21.1 kDa	No	0
ALDH7A1-213		H0YHM6	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	239 aa 25.8 kDa	No	0
ALDH7A1-215	P49419		Enzymes Metabolic proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Human disease related genes Mapped to neXtProt Protein evidence (Ezkurdia et al 2014) Show all	475 aa 51.4 kDa	No	0
ALDH7A1-216		A0A1B0GW82	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	545 aa 59.2 kDa	No	0
ALDH7A1-224		A0A1B0GTJ4	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	499 aa 53.9 kDa	No	0
ALDH7A1-227		A0A1B0GW77	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	554 aa 60 kDa	No	0
ALDH7A1-228		A0A1B0GV49	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	472 aa 51 kDa	No	0
ALDH7A1-231		A0A1B0GTY9	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	479 aa 51.9 kDa	No	0
ALDH7A1-232		A0A1B0GTG2	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	536 aa 58.1 kDa	No	0
ALDH7A1-234		A0A1B0GUA1	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	521 aa 56.5 kDa	No	0
ALDH7A1-235		A0A1B0GUY0	Metabolic proteins Predicted intracellular proteins Human disease related genes Protein evidence (Ezkurdia et al 2014)	348 aa 37.7 kDa	No	0
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