BETA
GENERAL INFORMATIONi
Gene namei RBPJ
Synonyms CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH
Gene descriptioni Recombination signal binding protein for immunoglobulin kappa J region
Protein classi Disease related genes
Housekeeping proteins
Human disease related genes
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
Regulates ABCC1, ACTA2, ADAM19, AHSP, AKT1… (156 genes, show all)
Regulated by CEBPB, RBPJ, SOX2
GENE INFORMATIONi
Chromosome 4
Cytoband p15.2
Chromosome location (bp) 26163455 - 26435131
Number of transcriptsi 29
Ensembl ENSG00000168214 (version 109)
Entrez gene 3516
HGNC HGNC:5724
UniProt Q06330
GeneCards RBPJ


PROTEIN FUNCTION
Protein function (UniProt)i Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations 1, 2. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes. Probably represses or activates transcription via the recruitment of chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins, respectively. Specifically binds to the immunoglobulin kappa-type J segment recombination signal sequence. Binds specifically to methylated DNA 3. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) 4. Negatively regulates the phagocyte oxidative burst in response to bacterial infection by repressing transcription of NADPH oxidase subunits (By similarity). show less
Molecular function (UniProt)i Activator, DNA-binding, Repressor
Biological process (UniProt)i Host-virus interaction, Notch signaling pathway, Transcription, Transcription regulation
Gene summary (Entrez)i The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013] show less
TRANSCRIPTION FACTOR TARGETS
Target gene MOA Evidence References (PubMed IDs)
ABCC1 NA ExTRI; NTNU.Curated 22143792
ACTA2 -1.0 TFactS 15634680, 15987768, 16741155
ADAM19 1.0 TFactS 10933396
AHSP 1.0 TFactS 15979417
AKT1 NA ExTRI 24113181
ASCL1 -1.0 ExTRI; Pavlidis2021; TFactS 11306509, 22718343, 9102301, 9133387
ATM 1.0 TFactS 15979417
ATP5PD -1.0 TFactS 15979417
BCL2 1.0 TFactS 9881968
BIRC5 NA ExTRI; NTNU.Curated 21555376
Show allShow less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
RBPJ-201
ENSP00000345206
ENST00000342295 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 500 aa
55.6 kDa 		No 0
RBPJ-202
ENSP00000340124
ENST00000342320 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 486 aa
54.4 kDa 		No 0
RBPJ-203
ENSP00000305815
ENST00000345843 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 465 aa
51.9 kDa 		No 0
RBPJ-204
ENSP00000339699
ENST00000348160 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 486 aa
54.4 kDa 		No 0
RBPJ-205
ENSP00000347659
ENST00000355476 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001756 [somitogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003157 [endocardium development]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006959 [humoral immune response]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0007507 [heart development]
GO:0008283 [cell population proliferation]
GO:0009912 [auditory receptor cell fate commitment]
GO:0009957 [epidermal cell fate specification]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0021983 [pituitary gland development]
GO:0030097 [hemopoiesis]
GO:0030154 [cell differentiation]
GO:0030182 [neuron differentiation]
GO:0030183 [B cell differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035019 [somatic stem cell population maintenance]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0042742 [defense response to bacterium]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045596 [negative regulation of cell differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0047485 [protein N-terminus binding]
GO:0048505 [regulation of timing of cell differentiation]
GO:0048733 [sebaceous gland development]
GO:0048820 [hair follicle maturation]
GO:0048844 [artery morphogenesis]
GO:0050673 [epithelial cell proliferation]
GO:0050678 [regulation of epithelial cell proliferation]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060412 [ventricular septum morphogenesis]
GO:0060486 [club cell differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0060844 [arterial endothelial cell fate commitment]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072089 [stem cell proliferation]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:1901297 [positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
GO:2000241 [regulation of reproductive process]
GO:2000647 [negative regulation of stem cell proliferation]
Show all
 487 aa
54.3 kDa 		No 0
RBPJ-206
ENSP00000354528
ENST00000361572 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 500 aa
55.6 kDa 		No 0
RBPJ-207
ENSP00000421804
ENST00000504423 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
H0Y8R3
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 465 aa
51.9 kDa 		No 0
RBPJ-208
ENSP00000423703
ENST00000504907 		D6R927
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 382 aa
43.5 kDa 		No 0
RBPJ-209
ENSP00000424459
ENST00000504938 		D6RB37
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 143 aa
16.4 kDa 		No 0
RBPJ-211
ENSP00000426872
ENST00000505958 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
D6RE93
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 486 aa
54.4 kDa 		No 0
RBPJ-213
ENSP00000425750
ENST00000506956 		D6RIZ8
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 97 aa
11.3 kDa 		No 0
RBPJ-214
ENSP00000423907
ENST00000507561 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 465 aa
51.9 kDa 		No 0
RBPJ-215
ENSP00000422617
ENST00000507574 		D6RBQ8
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 157 aa
17.9 kDa 		No 0
RBPJ-216
ENSP00000424804
ENST00000509158 		D6RF98
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 434 aa
48.8 kDa 		No 0
RBPJ-221
ENSP00000422838
ENST00000511546 		D6R9X3
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 107 aa
12.4 kDa 		No 0
RBPJ-222
ENSP00000424789
ENST00000512351 		D6RAT2
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 94 aa
10.9 kDa 		No 0
RBPJ-223
ENSP00000423644
ENST00000512671 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
D6R946
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 500 aa
55.6 kDa 		No 0
RBPJ-227
ENSP00000423575
ENST00000514675 		D6R9K5
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 110 aa
12.8 kDa 		No 0
RBPJ-228
ENSP00000425061
ENST00000514730 		D6REC2
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 113 aa
13.1 kDa 		No 0
RBPJ-229
ENSP00000424989
ENST00000514807 		D6REP3
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
 GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
 48 aa
5.7 kDa 		No 0
RBPJ-231
ENSP00000423406
ENST00000515573 		D6RA45
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 189 aa
21.5 kDa 		No 0
RBPJ-234
ENSP00000506443
ENST00000680140 		A0A7P0Z4N7
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 440 aa
49.3 kDa 		No 0
RBPJ-237
ENSP00000506628
ENST00000680511 		A0A7P0TBJ4
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 434 aa
48.8 kDa 		No 0
RBPJ-238
ENSP00000505493
ENST00000680928 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 486 aa
54.4 kDa 		No 0
RBPJ-240
ENSP00000504964
ENST00000681093 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 486 aa
54.4 kDa 		No 0
RBPJ-241
ENSP00000505479
ENST00000681260 		A0A7P0T947
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 463 aa
51.7 kDa 		No 0
RBPJ-242
ENSP00000505255
ENST00000681264 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 465 aa
51.9 kDa 		No 0
RBPJ-244
ENSP00000505636
ENST00000681484 		Q06330
[Direct mapping] Recombining binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Immunoglobulin fold
   CollecTRI - Gene Regulatory Network
Disease related genes
Human disease related genes
   Congenital malformations
   Other congenital malformations
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003176 [aortic valve development]
GO:0003177 [pulmonary valve development]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0010628 [positive regulation of gene expression]
GO:0017053 [transcription repressor complex]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060379 [cardiac muscle cell myoblast differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140297 [DNA-binding transcription factor binding]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 465 aa
51.9 kDa 		No 0
RBPJ-248
ENSP00000505922
ENST00000681856 		A0A7P0T9Y9
[Direct mapping] Recombining-binding protein suppressor of hairless
Housekeeping proteins
   Housekeeping in single cell types
   Housekeeping in tissues
   Housekeeping in single nuclei brain
   Housekeeping in cell lines
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
   CollecTRI - Gene Regulatory Network
Human disease related genes
   Congenital malformations
   Other congenital malformations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005634 [nucleus]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
Show all
 457 aa
51.1 kDa 		No 0

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