General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
G-protein coupled receptors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Membrane
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
1
HUMAN PROTEIN ATLAS INFORMATIONi
Summary of RNA expression based on cell line data from the DepMap portal and cell line data generated within the Human Protein Atlas project.
Cell line expression clusteri
The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.
Not detected - no cluster assigned
Cell line specificityi
RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.
Not detected
Tau specificity scorei
Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.
Not detected
Cell line distributioni
RNA distribution category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.
Not detected
Protein evidencei
Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.
Evidence at transcript level
CELL LINE GROUPSi
This figure is comparatively showing RNA level (nTPM) and Protein level (nRPX) of various cell line groups of this particular gene. It is possible to reorder the Barchart by the levels of RNA expression or the cell line group names.
Cell line categories
Alphabetical
Expression
RNA specificity: Not detected
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines.The analyzed cell lines are grouped according to cancer type. Detailed information about the groups is revealed by hovering over the corresponding bar in the chart. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cancer cell line group. The size of the circle corresponds to the median Normalized Relative Protein Expression (nRPX) for the cell lines with MS data in each group, the color represents the tissue type to which the cancer belongs with the intensity of the color reflecting the percentage of the cell lines in the group showing expression of the protein according to MS data. A white circle means that the protein was not detected by MS in corresponding cell lines, while no circle means that MS data was not available for the cell lines.
Please refer to the method of this section for more details.
COMMON CELL LINESi
Similar to the cell line group figure above, this figure is relatively comparing RNA level (nTPM) and Protein level (nRPX) of each cell line in the cell line group of this particular gene. It is possible to reorder the Barchart by the levels of RNA expression or the cell line group names.
Alphabetical
Expression
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
CELL LINE DATA
Alphabetical
Expression
Adrenocortical cancer (n=1)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Bile duct cancer (n=7)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Bladder cancer (n=26)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Bone cancer (n=21)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Brain cancer (n=79)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Breast cancer (n=63)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Cervical cancer (n=8)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Colorectal cancer (n=63)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Esophageal cancer (n=27)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Gallbladder cancer (n=1)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Gastric cancer (n=42)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Head and Neck cancer (n=38)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Kidney cancer (n=35)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Leukemia (n=93)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Liver cancer (n=24)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Lung cancer (n=232)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Lymphoma (n=76)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Myeloma (n=34)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Neuroblastoma (n=17)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Non-cancerous (n=63)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Ovarian cancer (n=59)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Pancreatic cancer (n=46)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Prostate cancer (n=8)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Rhabdoid (n=14)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Sarcoma (n=15)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Skin cancer (n=62)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Testis cancer (n=1)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Thyroid cancer (n=11)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Uncategorized (n=11)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
Alphabetical
Expression
Uterine cancer (n=29)
RNAi
RNA expression data as normalized transcript per million (nTPM) values of cancer cell lines. Similar to the cell line groups above, this plot show each individual nTPM of the gene in each cell line. More information and cell line data can be found in the Cell line resource.
Proteini
Protein expression based on the MS proteomics dataset from the Pan-Cancer Atlas project is represented by a circle for each cell line.The size of the circle corresponds to the Normalized Relative Protein Expression (nRPX) value for the cell line and the color represents the tissue type to which the cell line is related. A white circle means that the protein was not detected by MS in the cell line, while no circle means that MS data was not available for the cell line.
Please refer to the method of this section for more details.
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The Human Protein Atlas project is funded
