LRRC10B protein expression summary - The Human Protein Atlas

LRRC10B

Search result

Field

Cluster

Cell type

Category

Cluster

Cluster

Subsystem

BETA

SUMMARY

TISSUE

BRAIN

SINGLE CELL

IMMUNE

SUBCELL

CANCER

BLOOD

CELL LINE

STRUCTURE

INTERACTION

METABOLIC

ISOFORM

EVOLUTION

LRRC10B

LRRC10B INFORMATION
Proteinⁱ Full gene name according to HGNC.	Leucine rich repeat containing 10B
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LRRC10B
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).
Protein evidence	Evidence at protein level (all genes)
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1
Protein interactions	Interacting with 1 protein

LRRC10B AI GENERATED INFOGRAPHICⁱ This infographic was generated by AI (Gemini) using only data presented in the Human Protein Atlas v25. It is a quick overview and may contain errors or simplifications, so please check the full data on this gene page before drawing conclusions. Read more

PROTEIN EXPRESSION AND LOCALIZATION
Tissue profileⁱ A summary of the overall protein expression profile across the analyzed normal tissues based on knowledge-based annotation, presented in the Tissue resource. "Estimation of protein expression could not be performed. View primary data." is shown for genes where available RNA-seq and gene/protein characterization data in combination with immunohistochemistry data has been evaluated as not sufficient to yield a reliable estimation of the protein expression profile.	Not available
Tissue specificity (MS)	Tissue enriched (Ovary)
Cell type specificity (DVP)	Cell type enriched (Smooth muscle cells)
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Nucleoplasm In addition localized to the Nucleoli
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular

TISSUE RNA EXPRESSION
Tissue specificityⁱ The RNA specificity category is based on normalized mRNA expression levels in the consensus dataset, calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Tissue enhanced (Brain, Fallopian tube, Pituitary gland)
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Brain - Neuronal signaling (mainly)
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category	Domain enhanced (Striatum)
Brain expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Neurons - Mixed function (mainly)
Isoform expression categoryⁱ The expression category reflects the overall expression pattern for the gene based on expression profiles for all individual isoforms. Read more	Single isoform gene
Evolutionary conservation categoryⁱ Conservation category is a categoric annotation that intends to capture the available pairwise species overlap annotations into one metric. The categories range from: Complete, Partial and Minimal Conservation for conserved genes; and Tissue elevation shift, human specific tissue elevated, Non-Human tissue elevated, Human specific detected and Human not detected for non conserved genes.	Partial conservation (Tissue elevated)

CELL TYPE RNA EXPRESSION
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Respiratory ciliated cells, Fallopian tube ciliated cells, Endometrial ciliated cells, Epididymal efferent duct ciliated cells, Vascular smooth muscle cells, Pancreatic islet cells, Ependymal cells)
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Ciliated cells - Cilia assembly & function (mainly)
Bulk RNA deconvolution classificationⁱ Genes can have enriched specificity in different cell types in one or several tissues, or be enriched in a core cell type that appears in many different tissues.	Cell type enriched in 7 tissues
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected in immune cells
Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Not detected - no cluster assigned

CANCER & CELL LINES
Cancer specificity (RNA)ⁱ Specificity of RNA expression (TCGA dataset) across 21 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity or not detected.	Cancer enhanced (Uterine Corpus Endometrial Carcinoma)
Cancer specificity (Protein)ⁱ Specificity of protein abundance in tumor samples from 25 cancer types, measured by mass spectrometry (ProteinTalks DB dataset), is categorized as cancer enriched, group enriched, cancer enhanced, low cancer specificity or not detected.	Not detected
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	DU4475 - Unknown function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from cancer cell lines in the Human Protein Atlas grouped according to type of cancer. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cancer specificity

PROTEINS IN BLOOD
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search.	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics dataset obtained from the PeptideAtlas.	No
Proximity extension assayⁱ Indicates whether the protein has been measured (Data available) or not (Not available) using the Olink Explore HT proximity extension assay platform.	Not available
SomaScanⁱ Indicates whether the protein has been measured (Data available) or not (Not available) using the SomaScan 11K platform.	Not available

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut and Alice Wallenberg Foundation.

contact@proteinatlas.org

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.