Expression of CWC25 in testis cancer - The Human Protein Atlas

TESTICULAR GERM CELL TUMOR (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

CWC25 is not prognostic in Testicular Germ Cell Tumor (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 14.8

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

RNA samplesⁱ

Average pTPM

13.9

Number of samples

133

Samples

Sample	Description	pTPM
TCGA-2G-AAH3-01A	20 years, male, white, stage:Stage I, alive, 1822 days	50.1
TCGA-SN-A84Y-01A	18 years, male, white, stage:Stage IS, alive, 524 days	38.6
TCGA-4K-AA1G-01A	34 years, male, white, stage:Stage IS, alive, 436 days	33.9
TCGA-2G-AAFE-01A	37 years, male, white, stage:Stage IIA, alive, 4702 days	33.7
TCGA-SB-A76C-01A	38 years, male, white, stage:'--, alive, 42 days	33.2
TCGA-W4-A7U3-01A	26 years, male, white, stage:'--, alive, 149 days	26.4
TCGA-S6-A8JX-01A	27 years, male, white, stage:Stage IB, alive, 552 days	25.9
TCGA-YU-AA4L-01A	27 years, male, black or african american, stage:Stage IIIC, alive, 1573 days	25.9
TCGA-XE-AAO6-01A	47 years, male, white, stage:Stage IA, alive, 240 days	24.7
TCGA-2G-AAGN-01A	41 years, male, white, stage:Stage IIIB, alive, 3656 days	23.1
TCGA-2G-AAGA-01A	38 years, male, white, stage:Stage IIA, alive, 2439 days	22.6
TCGA-ZM-AA0B-01A	32 years, male, white, stage:Stage IA, alive, 838 days	22.4
TCGA-VF-A8AB-01A	31 years, male, black or african american, stage:Stage IA, alive, 760 days	21.9
TCGA-XY-A8S2-01A	67 years, male, white, stage:Stage I, alive, 672 days	20.8
TCGA-2G-AAGY-01A	28 years, male, white, stage:Stage IS, alive, 5329 days	19.7
TCGA-ZM-AA06-01A	45 years, male, white, stage:Stage IB, alive, 1498 days	19.2
TCGA-YU-A90P-01A	25 years, male, white, stage:Stage IA, alive, 2069 days	19.2
TCGA-YU-AA61-01A	29 years, male, white, stage:Stage IS, alive, 864 days	18.8
TCGA-WZ-A7V4-01A	28 years, male, white, stage:Stage I, alive, 894 days	18.4
TCGA-2G-AAHC-01A	33 years, male, white, stage:Stage IS, alive, 5539 days	18.1
TCGA-SN-A6IS-01A	26 years, male, white, stage:Stage IS, alive, 496 days	18.0
TCGA-XE-AAOC-01A	31 years, male, white, stage:Stage IA, alive, 270 days	17.9
TCGA-2X-A9D6-01A	42 years, male, white, stage:Stage I, alive, 607 days	17.3
TCGA-2G-AAGE-01A	21 years, male, white, stage:Stage IS, alive, 2478 days	17.3
TCGA-X3-A8G4-01A	33 years, male, white, stage:Stage IS, alive, 856 days	17.2
TCGA-S6-A8JY-01A	27 years, male, white, stage:Stage IS, alive, 278 days	17.2
TCGA-2G-AAGT-01A	30 years, male, white, stage:Stage IS, alive, 4406 days	16.9
TCGA-2G-AAGC-01A	28 years, male, white, stage:Stage IS, alive, 2585 days	16.6
TCGA-2G-AAH0-01A	30 years, male, white, stage:Stage IS, alive, 5477 days	16.0
TCGA-2G-AAGO-01A	41 years, male, white, stage:Stage IS, alive, 4026 days	16.0
TCGA-2G-AAH2-01A	20 years, male, white, stage:Stage IS, alive, 6060 days	16.0
TCGA-2X-A9D5-01A	49 years, male, white, stage:Stage I, alive, 435 days	15.7
TCGA-2G-AAG8-01A	21 years, male, white, stage:Stage IB, alive, 2289 days	15.7
TCGA-VF-A8AD-01A	36 years, male, white, stage:Stage IB, alive, 1006 days	15.7
TCGA-XE-AANV-01A	52 years, male, stage:Stage IB, alive, 1701 days	15.5
TCGA-2G-AAH4-01A	34 years, male, white, stage:Stage II, alive, 6210 days	15.4
TCGA-2G-AAF8-01A	33 years, male, white, stage:Stage IA, alive, 3911 days	15.4
TCGA-2G-AAH8-01A	45 years, male, white, stage:Stage IIIC, alive, 2248 days	15.3
TCGA-2G-AAL5-01A	31 years, male, white, stage:Stage I, alive, 7437 days	15.2
TCGA-2G-AAGX-01A	22 years, male, white, stage:Stage IA, alive, 5514 days	15.1
TCGA-2G-AAF4-01A	30 years, male, white, stage:Stage I, alive, 2315 days	15.0
TCGA-2G-AAFG-01A	30 years, male, white, stage:Stage IS, alive, 6183 days	14.9
TCGA-2G-AAG5-01A	36 years, male, white, stage:Stage IS, alive, 2299 days	14.9
TCGA-2G-AAEW-01A	31 years, male, white, stage:Stage IS, dead, 618 days	14.7
TCGA-2G-AAHG-01A	25 years, male, white, stage:Stage I, alive, 1819 days	14.7
TCGA-2G-AAG7-01A	33 years, male, white, stage:Stage IS, alive, 2475 days	14.4
TCGA-2G-AAG6-01A	24 years, male, white, stage:Stage IS, alive, 2231 days	14.3
TCGA-2G-AAGJ-01A	28 years, male, black or african american, stage:Stage IA, alive, 2938 days	14.2
TCGA-XE-AAO3-01A	33 years, male, asian, stage:Stage I, alive, 2857 days	14.2
TCGA-VF-A8AC-01A	29 years, male, white, stage:Stage IA, alive, 1083 days	14.2
TCGA-2G-AAKH-01A	19 years, male, white, stage:Stage II, alive, 6862 days	14.1
TCGA-YU-A94I-01A	66 years, male, stage:Stage IA, alive, 536 days	14.1
TCGA-ZM-AA0D-01A	34 years, male, white, stage:Stage IA, alive, 848 days	14.0
TCGA-4K-AAAL-01A	31 years, male, white, stage:Stage IS, alive, 483 days	14.0
TCGA-XE-AAO4-01A	40 years, male, white, stage:Stage IA, alive, 367 days	14.0
TCGA-2G-AAKG-01A	22 years, male, white, stage:Stage I, alive, 6598 days	13.9
TCGA-S6-A8JW-01A	37 years, male, white, stage:Stage IS, alive, 698 days	13.9
TCGA-2G-AAGV-01A	23 years, male, white, stage:'--, alive, 4527 days	13.9
TCGA-2G-AAGK-01A	20 years, male, white, stage:Stage IS, alive, 3621 days	13.8
TCGA-2G-AAFV-01A	31 years, male, white, stage:Stage IS, alive, 1389 days	13.7
TCGA-VF-A8A9-01A	31 years, male, white, stage:Stage IA, alive, 1119 days	13.7
TCGA-WZ-A7V5-01A	27 years, male, white, stage:Stage I, alive, 1061 days	13.6
TCGA-2G-AAFI-01A	41 years, male, white, stage:Stage IB, alive, 675 days	13.4
TCGA-2G-AAGI-01A	33 years, male, white, stage:Stage IS, alive, 3137 days	13.2
TCGA-4K-AA1I-01A	26 years, male, white, stage:Stage IA, alive, 3 days	13.2
TCGA-W4-A7U4-01A	23 years, male, white, stage:'--, alive, 738 days	13.0
TCGA-XE-A8H4-01A	23 years, male, white, stage:Stage IA, alive, 559 days	13.0
TCGA-2G-AAHN-01A	32 years, male, white, stage:Stage I, alive, 6445 days	13.0
TCGA-XE-AAOD-01A	39 years, male, white, stage:Stage IB, alive, 2058 days	12.9
TCGA-2G-AAF6-01A	28 years, male, white, stage:Stage IS, alive, 3491 days	12.8
TCGA-YU-A90Y-01A	23 years, male, black or african american, stage:Stage IIIC, dead, 17 days	12.8
TCGA-XE-AANI-01A	37 years, male, white, stage:Stage IS, alive, 1041 days	12.8
TCGA-2G-AAG0-01A	23 years, male, white, stage:Stage IS, alive, 1529 days	12.7
TCGA-2G-AAHA-01A	48 years, male, white, stage:Stage IB, alive, 3349 days	12.7
TCGA-SN-A84W-01A	30 years, male, white, stage:Stage IS, alive, 293 days	12.6
TCGA-2G-AAF1-01A	28 years, male, asian, stage:Stage IS, alive, 1403 days	12.6
TCGA-XE-AANR-01A	23 years, male, white, stage:Stage I, alive, 14 days	12.6
TCGA-SO-A8JP-01A	29 years, male, white, stage:Stage I, alive, 540 days	12.5
TCGA-2G-AAGG-01A	20 years, male, white, stage:Stage IIIC, alive, 2611 days	12.5
TCGA-VF-A8AA-01A	51 years, male, white, stage:Stage I, alive, 1146 days	12.4
TCGA-2G-AALP-01A	43 years, male, white, stage:Stage IIIB, alive, 2645 days	12.3
TCGA-2G-AAFJ-01A	23 years, male, asian, stage:'--, alive, 792 days	12.1
TCGA-2G-AAGP-01A	33 years, male, white, stage:Stage IIA, alive, 4018 days	12.0
TCGA-2G-AAFY-01A	24 years, male, white, stage:Stage IIA, alive, 1099 days	11.8
TCGA-2G-AAG9-01A	25 years, male, white, stage:Stage IIIB, alive, 2234 days	11.8
TCGA-2G-AAGM-01A	51 years, male, white, stage:Stage IS, alive, 3891 days	11.8
TCGA-XE-AANJ-01A	39 years, male, white, stage:Stage IS, alive, 2007 days	11.6
TCGA-W4-A7U2-01A	26 years, male, white, stage:'--, alive, 1263 days	11.5
TCGA-2G-AAHL-01A	26 years, male, white, stage:Stage I, alive, 7081 days	11.5
TCGA-2G-AAHT-01A	32 years, male, white, stage:Stage IS, alive, 542 days	11.5
TCGA-XY-A9T9-01A	37 years, male, white, stage:Stage IS, alive, 281 days	11.4
TCGA-YU-A94D-01A	28 years, male, stage:Stage IIIB, alive, 2167 days	11.4
TCGA-2G-AAGZ-01A	27 years, male, white, stage:Stage IIIA, alive, 5233 days	11.4
TCGA-YU-A90S-01A	26 years, male, white, stage:Stage IA, alive, 971 days	11.3
TCGA-XE-A8H5-01A	29 years, male, stage:Stage IS, alive, 1217 days	11.0
TCGA-2G-AAFO-01A	33 years, male, white, stage:Stage IIA, alive, 685 days	10.9
TCGA-2G-AAKM-01A	14 years, male, white, stage:Stage II, dead, 6972 days	10.9
TCGA-ZM-AA0N-01A	44 years, male, white, stage:Stage IB, alive, 634 days	10.8
TCGA-2G-AAFH-01A	38 years, male, white, stage:Stage IIB, alive, 1375 days	10.4
TCGA-4K-AA1H-01A	26 years, male, white, stage:Stage IA, alive, 518 days	10.3
TCGA-XE-AAOJ-01A	24 years, male, white, stage:Stage IS, alive, 1550 days	10.2
TCGA-YU-A90W-01A	45 years, male, white, stage:Stage IA, alive, 1113 days	10.1
TCGA-2G-AAFN-01A	26 years, male, white, stage:Stage IIIB, alive, 773 days	9.9
TCGA-2G-AAFZ-01A	32 years, male, white, stage:Stage III, alive, 1353 days	9.8
TCGA-ZM-AA0F-01A	35 years, male, white, stage:Stage IA, alive, 681 days	9.8
TCGA-VF-A8A8-01A	18 years, male, white, stage:Stage IA, alive, 1131 days	9.8
TCGA-SB-A6J6-01A	22 years, male, white, stage:Stage IA, alive, 413 days	9.7
TCGA-XE-A8H1-01A	24 years, male, white, stage:Stage IS, alive, 209 days	9.7
TCGA-ZM-AA0E-01A	39 years, male, white, stage:Stage IA, alive, 811 days	9.6
TCGA-ZM-AA0H-01A	50 years, male, white, stage:Stage IS, alive, 1736 days	9.6
TCGA-VF-A8AE-01A	39 years, male, white, stage:Stage IA, alive, 727 days	9.5
TCGA-YU-A90Q-01A	21 years, male, stage:Stage IB, alive, 1964 days	9.5
TCGA-2G-AAFM-01A	31 years, male, white, stage:Stage IIA, alive, 503 days	9.5
TCGA-SN-A84X-01A	21 years, male, white, stage:Stage IS, alive, 312 days	9.4
TCGA-YU-A912-01A	34 years, male, black or african american, stage:Stage IIIC, alive, 866 days	9.3
TCGA-WZ-A8D5-01A	38 years, male, white, stage:'--, alive, 774 days	8.7
TCGA-2G-AAHP-01A	31 years, male, white, stage:Stage IS, alive, 5667 days	8.4
TCGA-2G-AAGF-01A	28 years, male, white, stage:Stage IS, alive, 2734 days	8.3
TCGA-2G-AAGW-01A	38 years, male, white, stage:Stage IS, alive, 4899 days	8.3
TCGA-2G-AAG3-01A	53 years, male, white, stage:Stage IS, alive, 1593 days	8.2
TCGA-2G-AAL7-01A	32 years, male, white, stage:Stage IS, alive, 3991 days	7.9
TCGA-XE-AAOL-01A	38 years, male, black or african american, stage:Stage I, alive, 13 days	7.5
TCGA-XE-AAOB-01A	27 years, male, white, stage:Stage IS, dead, 513 days	7.1
TCGA-WZ-A7V3-01A	20 years, male, white, stage:Stage I, alive, 753 days	7.1
TCGA-2G-AAEX-01A	38 years, male, white, stage:Stage IS, alive, 1259 days	6.5
TCGA-2G-AAGS-01A	39 years, male, white, stage:Stage IIIB, alive, 4816 days	6.2
TCGA-2G-AAFL-01A	35 years, male, white, stage:Stage IB, alive, 750 days	6.0
TCGA-2G-AAKL-01A	26 years, male, white, stage:Stage II, alive, 7023 days	5.6
TCGA-2G-AAKD-01A	18 years, male, white, stage:Stage III, alive, 6340 days	0.0
TCGA-XE-A9SE-01A	35 years, male, white, stage:Stage IA, alive, 708 days	0.0
TCGA-XY-A89B-01A	35 years, male, white, stage:Stage IA, alive, 471 days	0.0
TCGA-ZM-AA05-01A	36 years, male, white, stage:Stage IIC, alive, 1126 days	0.0
TCGA-XE-AAOF-01A	50 years, male, asian, stage:Stage IA, alive, 1268 days	0.0
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TESTIS CANCER - Cancer proteome, tumor vs adjacent non-tumor (ProteinTalks DB, TGCT)

Number of samples

50 (25 tumor / adjacent non-tumor pairs)

Detected in

22/25 tumors, 0/25 non-tumors

Tumor vs non-tumor

Not tested

Samples

Patient ID	Tumor	Non-tumor
TGCT_18	10.9	N/A
TGCT_12	10.6	N/A
TGCT_21	10.2	N/A
TGCT_14	10.1	N/A
TGCT_09	10.1	N/A
TGCT_16	9.9	N/A
TGCT_13	9.9	N/A
TGCT_25	9.9	N/A
TGCT_15	9.8	N/A
TGCT_23	9.7	N/A
TGCT_08	9.7	N/A
TGCT_10	9.6	N/A
TGCT_22	9.6	N/A
TGCT_20	9.6	N/A
TGCT_17	9.5	N/A
TGCT_02	9.5	N/A
TGCT_24	9.3	N/A
TGCT_03	9.2	N/A
TGCT_06	9.1	N/A
TGCT_19	9.1	N/A
TGCT_05	9.0	N/A
TGCT_01	8.8	N/A
TGCT_04	N/A	N/A
TGCT_07	N/A	N/A
TGCT_11	N/A	N/A
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TESTIS CANCER - Protein stainingⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample. Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes. Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based) Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts	Antibody HPA062997	Antibody CAB014874
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Seminoma, NOS
Carcinoma, Embryonal, NOS
Carcinoma, Embryonal, NOS Teratoma, malignant, NOS
Seminoma, NOS Carcinoma, Embryonal, NOS