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BETA
  • SUMMARY

  • TISSUE

  • BRAIN

  • SINGLE CELL

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  • EVOLUTION

  • PRRC2B
EVOLUTIONARY CEREBRAL CORTEX Show tissue menu
BRAIN73 EYE4 ENDOCRINE TISSUES5 RESPIRATORY SYSTEM6 PROXIMAL DIGESTIVE TRACT5 GASTROINTESTINAL TRACT11 LIVER & GALLBLADDER4 PANCREAS1 KIDNEY & URINARY BLADDER4 MALE REPRODUCTIVE SYSTEM11 BREAST & FEMALE REPRODUCTIVE SYSTEM10 MUSCLE & VASCULAR TISSUE11 CONNECTIVE & SOFT TISSUE15 SKIN4 BONE MARROW & LYMPHOID TISSUES7
Select an organ to show its tissues
AMYGDALA ANGULAR GYRUS ANNECTANT GYRUS ANTERIOR CINGULATE GYRUS CAUDATE NUCLEUS CAUDATE PUTAMEN CEREBELLUM CEREBRAL CORTEX CHOROID PLEXUS CINGULATE CORTEX CLAUSTRUM CORPUS CALLOSUM CUNEUS DORSAL HIPPOCAMPUS DORSAL ROOT GANGLION DORSAL SPINAL CORD ENTORHINAL CORTEX FRONTAL CORTEX FUSIFORM GYRUS
GENICULATE NUCLEUS GLOBUS PALLIDUS GYRUS RECTUS HABENULA HIPPOCAMPAL FORMATION HYPOTHALAMUS HYPOTHALAMUS, ANTERIOR HYPOTHALAMUS, POSTERIOR INFERIOR FRONTAL GYRUS INFERIOR OCCIPITAL GYRUS INFERIOR TEMPORAL GYRUS INSULAR CORTEX LATERAL THALAMIC NUCLEI MEDULLA OBLONGATA MIDBRAIN MIDDLE FRONTAL GYRUS MIDDLE TEMPORAL GYRUS MOTOR AND PREFRONTAL CORTEX MOTOR CORTEX
OCCIPITAL CORTEX OCCIPITAL GYRUS OLFACTORY BULB ORBITAL GYRUS PERIAQUEDUCTAL GRAY PONS POSTCENTRAL GYRUS POSTERIOR CINGULATE CORTEX POSTERIOR PARAHIPPOCAMPAL GYRUS POSTERIOR THALAMUS PRECENTRAL GYRUS PREFRONTAL CORTEX PREOPTIC AREA PUTAMEN RETROSPLENIAL AND CINGULATE CORTEX RETROSPLENIAL CORTEX SEPTAL AREA SEPTUM SOMATOSENSORY CORTEX
SPINAL CORD SUBICULUM SUBSTANTIA NIGRA SUPERIOR COLLICULI SUPERIOR FRONTAL GYRUS SUPERIOR PARIETAL LOBULE SUPERIOR TEMPORAL GYRUS SUPRAMARGINAL GYRUS TEMPORAL CORTEX THALAMUS VENTRAL FOREBRAIN VENTRAL HIPPOCAMPUS VENTRAL PALLIDUM VENTRAL SPINAL CORD VISUAL CORTEX WHITE MATTER
CORNEA HARDERIAN GLAND LENS RETINA
ADRENAL GLAND PARATHYROID GLAND PINEAL GLAND PITUITARY GLAND THYROID GLAND
BRONCHUS LARYNX LUNG NASOPHARYNX OLFACTORY EPITHELIUM TRACHEA
ESOPHAGUS LIP ORAL MUCOSA SALIVARY GLAND TONGUE
CECUM COLON DUODENUM ILEUM JEJUNUM RECTUM SMALL INTESTINE STOMACH STOMACH (LOWER) STOMACH (MIDDLE) STOMACH (UPPER)
GALLBLADDER LIVER LIVER (LOBE 1) LIVER (LOBE 4)
PANCREAS
KIDNEY KIDNEY (CORTEX) KIDNEY (MEDULLA) URINARY BLADDER
BULBOURETHRAL GLAND DUCTUS DEFERENS EPIDIDYMIS MALE PREPUTIAL GLAND PENIS PROSTATE PROSTATE (ANTERIOR) PROSTATE (VENTRAL) SEMINAL VESICLE TESTIS URETHRAL GLAND
BREAST CERVIX CLITORIS ENDOMETRIUM FALLOPIAN TUBE FEMALE PREPUTIAL GLAND OVARY PLACENTA UTERUS VAGINA
AORTA DIAPHRAGM HEART ATRIUM HEART MUSCLE HEART VALVE HEART WALL PERIPHERAL VASCULATURE SKELETAL MUSCLE SMOOTH MUSCLE SMOOTH MUSCLE (INTESTINE) SMOOTH MUSCLE (UTERUS)
ABDOMINAL ADIPOSE TISSUE ADIPOSE TISSUE BROWN ADIPOSE TISSUE DURA MATER EAR CANAL EAR CARTILAGE JOINT CARTILAGE MENINGES ORBITAL ADIPOSE TISSUE PERICARDIUM PERITONEUM PLEURA SUBCUTANEOUS ADIPOSE TISSUE SYNOVIAL TISSUE VAGUS NERVE
EYE LID SKIN SKIN (BACK) SKIN (GROIN)
APPENDIX BLOOD, PBMC BONE MARROW LYMPH NODE SPLEEN THYMUS TONSIL
HumanMacaqueMouseRatPig
Protein evolution
Brain
Evolutionary methods
CEREBRAL CORTEX - Expression summary
Protein expression
Cerebral cortexi

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

h
m
l
n
Endothelial cells: Low
Glial cells: Medium
Neuronal cells: High
Neuropil: Low
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

Scroll down to view mRNA expression data in more detail.

Consensus:66.6 nTPM
HPA:66.6 nTPM
HPA Brain:297.4 nTPM
HPA PFC Brain:45.6 nTPM
FANTOM5:191.9 Scaled Tags Per Million
Macaque:123.9 nTPM
Mouse:186.0 nTPM
Rat:123.5 nTPM
Pig:120.9 nTPM

CEREBRAL CORTEX - Antibody stainingi

Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.

Ascending and descending describe two types of gradient, based on difference in staining intensity between enterocytes in crypts and apical enterocytes.

Ascending - the staining intensity is stronger in apical enterocytes (towards the lumen) compared to enterocytes in the crypts (gland based)

Descending - the staining is weaker in apical enterocytes compared to enterocytes in crypts

Antibody HPA021022
Endothelial cells Low
Glial cells Medium
Neuronal cells High
Neuropil Low



CEREBRAL CORTEX - PROTEINTALKS DB MS
Median intensity 771
Sample Intensity
Cerebral cortex_01
1009
Cerebral cortex_02
617
Cerebral cortex_03
ND
Cerebral cortex_04
ND
Cerebral cortex_05
ND
Cerebral cortex_06
ND
Cerebral cortex_07
874
Cerebral cortex_08
755
Cerebral cortex_09
ND
Cerebral cortex_10
ND
Cerebral cortex_11
ND
Cerebral cortex_12
771
Cerebral cortex_13
695
Cerebral cortex_14
ND
Cerebral cortex_15
972
Cerebral cortex_16
ND
Cerebral cortex_17
ND
Cerebral cortex_18
1053
Cerebral cortex_19
772
Cerebral cortex_20
764
Cerebral cortex_21
ND
Cerebral cortex_22
ND
Cerebral cortex_23
714
Cerebral cortex_24
ND
Cerebral cortex_25
ND
Cerebral cortex_26
ND
Cerebral cortex_27
ND
Cerebral cortex_28
ND
Cerebral cortex_29
ND
Cerebral cortex_30
ND
Cerebral cortex_31
ND
Cerebral cortex_32
ND
Cerebral cortex_33
ND
Cerebral cortex_34
ND
Cerebral cortex_35
ND
Cerebral cortex_36
ND
Cerebral cortex_37
ND
Cerebral cortex_38
ND

CEREBRAL CORTEX - MANN MS
Median intensity 71676
Replicate Intensity
Cerebral cortex_01
64973
Cerebral cortex_02
71676
Cerebral cortex_03
130838

CEREBRAL CORTEX - HPA RNA-seqi

The RNA-seq details section shows detailed information about the individual samples used for the transcript profiling and results of the RNA-seq analysis.

Information about each individual sample is listed below, including gender, age, a tissue section image and estimated fractions of cell types. nTPM (normalized transcripts per million) values give a quantification of the gene abundance which is comparable between different genes and samples.

Average nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

66.6
N/A
Male, age 5
Cerebral cortex sample 48
nTPM: 91
overview
Female, age 40
Cerebral cortex sample 105
nTPM: 45.5
Cell types%
Neuronal cells:
35

Glial cells and endothelial cells:
65

overview
Male, age 70
Cerebral cortex sample 106
nTPM: 63.5
Cell types%
Neuronal cells:
35

Glial cells and endothelial cells:
65


CEREBRAL CORTEX - HPA Brain Stereo-seq

CEREBRAL CORTEX - HPA Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

297.4
Sample id Sample description nTPM
Angular gyrus
nTPM: 197.2
2602 Female, age 94, right hemisphere 217.7
1866 Male, age 76, both hemispheres 213.0
2722 Male, age 61, left hemisphere 207.7
2260 Female, age 72, left hemisphere 196.8
1790 Male, age 76, right hemisphere 193.5
2221 Female, age 67, right hemisphere 193.5
2103 Male, age 75, left hemisphere 179.6
2265 Female, age 91, left hemisphere 175.7
Angular gyrus (white matter)
nTPM: 164.5
1920 Male, age 76, both hemispheres 164.5
Anterior cingulate cortex, supragenual-dorsal
nTPM: 207.8
2342 Female, age 94, right hemisphere 217.7
2478 Female, age 67, right hemisphere 217.5
1896 Female, age 85, right hemisphere 215.3
2547 Male, age 74, left hemisphere 207.1
2472 Male, age 75, left hemisphere 181.4
Anterior cingulate cortex, supragenual-ventral
nTPM: 212.7
1761 Male, age 74, left hemisphere 233.9
2538 Male, age 75, left hemisphere 230.1
1755 Female, age 94, right hemisphere 213.9
1950 Female, age 85, right hemisphere 200.1
2479 Female, age 67, right hemisphere 185.4
Anterior insular cortex, dorsal
nTPM: 205.7
2670 Male, age 75, left hemisphere 228.9
2235 Female, age 91, right hemisphere 203.4
2506 Female, age 94, right hemisphere 202.2
2001 Male, age 76, right hemisphere 188.4
Anterior insular cortex, ventral
nTPM: 208.9
1925 Female, age 91, left hemisphere 230.0
2596 Male, age 75, left hemisphere 222.9
1852 Male, age 76, left hemisphere 210.0
2262 Female, age 67, right hemisphere 200.3
2507 Female, age 94, left hemisphere 198.8
2757 Male, age 61, right hemisphere 191.1
Area parastriata, inferior
nTPM: 192.9
1760 Female, age 67, left hemisphere 242.2
1758 Female, age 72, right hemisphere 241.2
1789 Male, age 76, right hemisphere 197.1
2421 Female, age 91, left hemisphere 189.2
2234 Male, age 75, left hemisphere 180.9
2268 Male, age 61, right hemisphere 169.6
2509 Female, age 94, left hemisphere 130.0
Area parastriata, parietal
nTPM: 172.3
2236 Female, age 91, left hemisphere 211.5
1785 Male, age 76, right hemisphere 194.6
2680 Female, age 94, right hemisphere 174.5
2233 Male, age 61, right hemisphere 151.3
2420 Male, age 75, left hemisphere 129.4
Area parastriata, superior
nTPM: 193.6
2881 Male, age 76, left hemisphere 272.6
1773 Female, age 91, left hemisphere 266.3
2684 Female, age 67, left hemisphere 194.3
2419 Male, age 75, right hemisphere 153.2
2604 Female, age 94, right hemisphere 148.5
2435 Male, age 61, left hemisphere 127.0
Area parastriata, temporal
nTPM: 187.0
1804 Male, age 76, right hemisphere 216.4
2471 Male, age 75, left hemisphere 203.3
2681 Female, age 94, right hemisphere 199.8
2424 Female, age 67, left hemisphere 166.5
2267 Male, age 61, right hemisphere 148.9
Area striata
nTPM: 182.4
1753 Female, age 72, right hemisphere 251.6
2679 Female, age 94, right hemisphere 188.2
2427 Female, age 91, left hemisphere 182.1
2002 Female, age 91, right hemisphere 168.9
1884 Male, age 76, left hemisphere 162.1
2417 Male, age 61, right hemisphere 141.7
Area striata (white matter)
nTPM: 162.2
2258 Female, age 91, left hemisphere 162.2
Claustrum
nTPM: 215.5
2645 Female, age 72, unknown 272.4
2568 Male, age 61, both hemispheres 246.7
2284 Female, age 91, both hemispheres 231.9
2196 Female, age 79, unknown 222.7
2198 Male, age 80, both hemispheres 214.5
1956 Male, age 74, unknown 207.5
2292 Female, age 85, both hemispheres 192.0
2491 Male, age 75, both hemispheres 177.9
2392 Female, age 94, both hemispheres 173.9
Corpus callosum, genu (white matter)
nTPM: 128.3
1849 Female, age 91, right hemisphere 136.2
2771 Male, age 75, left hemisphere 133.8
1886 Female, age 67, right hemisphere 130.2
1934 Male, age 61, right hemisphere 128.6
1887 Male, age 76, left hemisphere 125.7
1885 Female, age 94, left hemisphere 115.3
Corpus callosum, splenium (white matter)
nTPM: 137.1
2104 Male, age 75, left hemisphere 162.9
1946 Male, age 76, left hemisphere 154.6
2847 Female, age 67, right hemisphere 118.0
2238 Female, age 94, right hemisphere 112.8
Frontal eye field
nTPM: 210.8
2761 Female, age 94, left hemisphere 239.9
2543 Male, age 74, left hemisphere 220.2
2441 Male, age 75, left hemisphere 208.2
2147 Male, age 61, left hemisphere 175.0
Frontal operculum
nTPM: 167.0
2781 Female, age 85, right hemisphere 198.8
2348 Male, age 75, left hemisphere 166.1
2030 Male, age 61, right hemisphere 136.1
Fusiform gyrus
nTPM: 233.7
2784 Female, age 85, left hemisphere 295.0
2617 Female, age 94, left hemisphere 277.6
1807 Male, age 76, left hemisphere 241.3
2112 Male, age 80, both hemispheres 241.1
2074 Female, age 91, left hemisphere 203.6
2433 Female, age 72, left hemisphere 199.1
2431 Male, age 75, right hemisphere 178.5
Inferior frontal gyrus, opercular
nTPM: 229.7
2872 Female, age 94, right hemisphere 268.5
2867 Male, age 75, left hemisphere 251.3
2873 Female, age 85, left hemisphere 243.9
2869 Male, age 74, left hemisphere 239.7
2865 Male, age 61, left hemisphere 238.6
2875 Female, age 67, left hemisphere 236.3
2871 Female, age 94, left hemisphere 233.5
2868 Male, age 75, right hemisphere 230.2
2866 Male, age 61, right hemisphere 194.2
2874 Female, age 85, right hemisphere 161.1
Inferior parietal lobule
nTPM: 226.7
2876 Male, age 76, right hemisphere 277.0
2606 Female, age 67, right hemisphere 230.5
2599 Female, age 94, left hemisphere 215.7
2418 Male, age 75, left hemisphere 183.4
Inferior temporal gyrus
nTPM: 217.4
2689 Female, age 94, right hemisphere 244.6
1880 Male, age 80, right hemisphere 234.5
1808 Male, age 76, left hemisphere 217.6
1965 Female, age 91, left hemisphere 213.1
1970 Female, age 85, right hemisphere 199.0
2430 Male, age 75, right hemisphere 195.3
Intraparietal deep sulcus
nTPM: 192.2
2669 Male, age 75, left hemisphere 209.8
2798 Male, age 76, left hemisphere 208.9
2607 Female, age 67, right hemisphere 199.7
2230 Male, age 61, right hemisphere 192.3
2600 Female, age 94, right hemisphere 176.6
2102 Female, age 91, left hemisphere 166.1
Lingual gyrus
nTPM: 239.7
2618 Female, age 94, left hemisphere 272.5
2838 Male, age 80, right hemisphere 256.7
1893 Male, age 76, left hemisphere 231.4
2688 Male, age 75, right hemisphere 221.8
2073 Female, age 85, left hemisphere 215.9
Middle cingulate cortex
nTPM: 208.9
2539 Male, age 75, left hemisphere 222.1
2357 Female, age 67, right hemisphere 214.3
2028 Female, age 85, left hemisphere 207.6
2640 Female, age 94, right hemisphere 204.1
2633 Male, age 74, left hemisphere 196.1
Middle temporal gyrus
nTPM: 231.4
2611 Male, age 75, right hemisphere 251.8
2034 Female, age 91, right hemisphere 246.2
2616 Female, age 94, left hemisphere 229.3
1819 Male, age 80, right hemisphere 226.3
1799 Male, age 76, left hemisphere 203.1
Occipital cortex
nTPM: 198.8
2608 Female, age 67, both hemispheres 248.2
2677 Female, age 67, right hemisphere 230.0
1842 Male, age 76, right hemisphere 191.6
2470 Male, age 75, right hemisphere 165.5
2426 Male, age 75, midline 158.8
Occipital cortex (white matter)
nTPM: 142.0
2257 Female, age 67, both hemispheres 149.6
2259 Male, age 75, midline 134.5
Olfactory area
nTPM: 242.1
2222 Female, age 67, right hemisphere 276.6
2756 Female, age 67, right hemisphere 265.1
1805 Female, age 85, right hemisphere 255.9
2352 Female, age 94, right hemisphere 245.4
2542 Male, age 74, left hemisphere 231.8
2440 Male, age 75, left hemisphere 177.8
Olfactory tubercle
nTPM: 233.7
2487 Female, age 94, left hemisphere 246.8
1846 Male, age 80, right hemisphere 239.3
2856 Male, age 75, right hemisphere 230.3
1998 Female, age 91, both hemispheres 218.3
Orbitofrontal gyrus, anterior
nTPM: 297.4
2863 Female, age 85, right hemisphere 470.3
2862 Female, age 85, left hemisphere 241.3
2864 Female, age 67, left hemisphere 180.7
Paracentral lobule, anterior
nTPM: 213.4
1776 Female, age 85, right hemisphere 266.0
1754 Male, age 75, left hemisphere 231.0
2638 Female, age 94, right hemisphere 224.3
2474 Male, age 74, left hemisphere 207.8
2340 Female, age 67, right hemisphere 189.3
1926 Male, age 61, left hemisphere 162.0
Paracentral lobule, posterior
nTPM: 196.0
1775 Female, age 85, right hemisphere 236.0
1764 Male, age 74, right hemisphere 204.9
2345 Male, age 61, left hemisphere 202.8
2446 Male, age 75, left hemisphere 190.0
2551 Female, age 94, right hemisphere 146.1
Parahippocampal cortex (white matter)
nTPM: 158.3
2157 Female, age 91, both hemispheres 158.3
Parietal operculum
nTPM: 225.8
2719 Male, age 75, left hemisphere 263.2
1763 Male, age 74, left hemisphere 237.2
2552 Female, age 94, right hemisphere 209.2
2356 Female, age 67, right hemisphere 193.8
Parieto-insular cortex
nTPM: 215.3
2671 Male, age 75, left hemisphere 247.1
2831 Male, age 76, right hemisphere 221.8
2232 Male, age 61, right hemisphere 209.2
1976 Female, age 91, right hemisphere 200.7
2508 Female, age 94, right hemisphere 197.5
Parieto-occipital transitional area
nTPM: 192.2
2683 Female, age 67, left hemisphere 202.7
1784 Male, age 76, right hemisphere 199.7
2674 Female, age 94, right hemisphere 197.2
2468 Male, age 75, left hemisphere 183.8
2270 Male, age 61, right hemisphere 177.5
Parieto-temporal junction (white matter)
nTPM: 128.0
2469 Male, age 75, right hemisphere 172.0
2774 Male, age 61, right hemisphere 130.8
2770 Female, age 91, right hemisphere 130.4
2121 Male, age 76, left hemisphere 121.1
1999 Female, age 67, right hemisphere 113.9
1935 Female, age 94, right hemisphere 99.7
Piriform cortex
nTPM: 157.6
2347 Male, age 75, right hemisphere 174.9
2153 Female, age 85, left hemisphere 140.3
Postcentral gyrus
nTPM: 247.0
2533 Male, age 75, right hemisphere 247.0
Postcentral gyrus, dorsal
nTPM: 189.7
2544 Male, age 74, left hemisphere 222.4
1836 Female, age 85, right hemisphere 217.9
2350 Male, age 75, left hemisphere 192.0
2151 Male, age 61, left hemisphere 174.2
2339 Female, age 67, right hemisphere 167.4
2477 Female, age 94, right hemisphere 164.3
Postcentral gyrus, middle
nTPM: 213.7
2545 Male, age 74, left hemisphere 325.9
1897 Female, age 85, right hemisphere 200.0
2146 Female, age 67, right hemisphere 196.2
2444 Male, age 75, left hemisphere 185.3
2248 Male, age 61, left hemisphere 161.1
Postcentral gyrus, ventral
nTPM: 196.0
2836 Female, age 94, right hemisphere 210.8
2445 Male, age 75, left hemisphere 194.2
2024 Female, age 85, right hemisphere 182.9
Posterior cingulate cortex
nTPM: 261.2
1759 Male, age 74, right hemisphere 292.3
2553 Female, age 94, right hemisphere 286.9
2473 Male, age 75, left hemisphere 204.3
Posterior cingulate cortex, dorsal
nTPM: 198.4
2540 Male, age 75, right hemisphere 249.3
2076 Female, age 85, right hemisphere 207.4
2343 Male, age 61, left hemisphere 190.5
2641 Female, age 94, right hemisphere 184.5
2556 Female, age 67, right hemisphere 180.1
2634 Male, age 74, left hemisphere 178.9
Posterior cingulate cortex, ventral
nTPM: 190.5
2346 Male, age 61, left hemisphere 214.1
1994 Female, age 85, right hemisphere 204.7
1762 Female, age 94, right hemisphere 199.1
2541 Male, age 75, right hemisphere 192.8
2635 Male, age 74, left hemisphere 180.9
2448 Female, age 67, right hemisphere 151.4
Posterior insular cortex
nTPM: 239.4
2603 Female, age 94, left hemisphere 287.1
2832 Female, age 91, right hemisphere 275.0
2597 Male, age 75, left hemisphere 231.9
2511 Female, age 67, right hemisphere 219.8
2231 Male, age 61, left hemisphere 211.5
1823 Male, age 76, right hemisphere 211.3
Precentral gyrus
nTPM: 243.0
2557 Male, age 75, right hemisphere 243.0
Precentral gyrus, dorsal
nTPM: 179.3
1756 Male, age 74, left hemisphere 196.4
2354 Female, age 67, right hemisphere 180.5
2442 Male, age 75, left hemisphere 179.4
2476 Female, age 94, right hemisphere 161.1
Precentral gyrus, middle
nTPM: 179.1
2549 Female, age 94, right hemisphere 213.0
1909 Male, age 61, left hemisphere 185.3
1969 Female, age 67, right hemisphere 180.6
2443 Male, age 75, left hemisphere 168.4
2475 Male, age 74, right hemisphere 147.9
Precentral gyrus, ventral
nTPM: 209.5
2678 Male, age 74, left hemisphere 256.3
2630 Male, age 75, left hemisphere 208.7
2550 Female, age 94, right hemisphere 200.4
2662 Female, age 67, right hemisphere 172.8
Precuneus
nTPM: 200.3
1780 Female, age 91, right hemisphere 248.4
2594 Male, age 61, left hemisphere 233.0
1782 Male, age 76, right hemisphere 207.3
2510 Female, age 67, right hemisphere 184.5
2673 Female, age 94, right hemisphere 183.1
2467 Male, age 75, right hemisphere 145.2
Premotor cortex, dorsal
nTPM: 197.3
1878 Female, age 85, right hemisphere 209.4
2554 Female, age 67, right hemisphere 207.9
2536 Male, age 75, left hemisphere 198.5
2027 Male, age 61, left hemisphere 186.0
2631 Male, age 74, left hemisphere 184.7
Premotor cortex, ventral
nTPM: 215.2
1779 Male, age 61, left hemisphere 268.1
2637 Female, age 94, right hemisphere 230.2
1757 Male, age 74, left hemisphere 218.0
1777 Female, age 67, left hemisphere 205.1
2349 Male, age 75, left hemisphere 188.6
1881 Female, age 85, right hemisphere 181.0
Retrosplenial cortex
nTPM: 210.4
1914 Male, age 76, right hemisphere 245.2
2675 Female, age 94, left hemisphere 223.4
1951 Male, age 61, right hemisphere 162.7
Somatomor cortex, precentral gyrus (white matter)
nTPM: 220.2
2439 Male, age 75, right hemisphere 220.2
Somatosensory cortex, postcentral gyrus, ventral (white matter)
nTPM: 229.1
2623 Male, age 75, right hemisphere 229.1
Subcentral gyrus, S2
nTPM: 214.2
2555 Female, age 67, right hemisphere 251.7
2839 Female, age 94, right hemisphere 243.3
2762 Male, age 74, left hemisphere 209.1
2072 Male, age 61, left hemisphere 201.5
1964 Female, age 85, right hemisphere 192.5
2351 Male, age 75, left hemisphere 186.9
Superior parietal lobule
nTPM: 198.6
2605 Female, age 67, right hemisphere 242.1
2672 Female, age 94, right hemisphere 233.5
2229 Male, age 61, right hemisphere 188.2
1800 Male, age 76, right hemisphere 168.5
1992 Female, age 91, right hemisphere 160.7
Superior temporal gyrus
nTPM: 225.7
2615 Female, age 94, left hemisphere 258.8
1844 Female, age 91, left hemisphere 228.3
1843 Male, age 76, left hemisphere 217.2
2687 Male, age 75, right hemisphere 216.4
2025 Male, age 80, right hemisphere 207.8
Supplementary motor cortex
nTPM: 198.3
2548 Female, age 94, right hemisphere 226.4
2537 Male, age 75, left hemisphere 206.7
2632 Male, age 74, left hemisphere 192.5
1993 Male, age 61, left hemisphere 167.6
Supramarginal gyrus
nTPM: 207.8
2513 Female, age 72, left hemisphere 227.7
1798 Male, age 76, right hemisphere 215.0
1991 Female, age 91, right hemisphere 207.2
2601 Female, age 94, left hemisphere 205.8
2415 Male, age 61, left hemisphere 183.2
Temporal pole
nTPM: 245.4
1832 Female, age 91, left hemisphere 285.7
2612 Female, age 94, left hemisphere 263.8
1853 Female, age 85, right hemisphere 246.5
1826 Male, age 76, right hemisphere 225.0
2518 Male, age 75, right hemisphere 206.2
Temporal white matter
nTPM: 141.4
2524 Female, age 85, left hemisphere 172.8
1801 Male, age 76, left hemisphere 150.1
2254 Male, age 75, right hemisphere 149.0
2736 Female, age 91, right hemisphere 128.1
2523 Female, age 94, left hemisphere 107.1
Temporo-insular cortex, parainsular gyrus
nTPM: 208.1
2676 Female, age 94, right hemisphere 280.7
2598 Male, age 75, left hemisphere 236.2
1802 Male, age 76, left hemisphere 233.6
2264 Female, age 91, right hemisphere 191.6
2416 Male, age 61, right hemisphere 154.1
2512 Female, age 67, right hemisphere 152.4
Temporo-occipital transitional zone
nTPM: 220.6
1900 Male, age 76, left hemisphere 229.7
1793 Male, age 80, right hemisphere 228.6
2251 Female, age 85, right hemisphere 203.5
Transversal temporal gyrus, anterior
nTPM: 210.5
2610 Male, age 75, right hemisphere 240.8
1888 Female, age 91, left hemisphere 223.6
1809 Male, age 76, right hemisphere 204.2
1910 Male, age 80, right hemisphere 202.8
2522 Female, age 94, left hemisphere 181.1
Transversal temporal gyrus, posterior
nTPM: 203.5
2833 Male, age 80, right hemisphere 225.6
2614 Female, age 94, left hemisphere 224.7
1967 Female, age 91, right hemisphere 212.2
1922 Male, age 76, left hemisphere 198.4
2520 Male, age 75, right hemisphere 156.4

CEREBRAL CORTEX - HPA PFC Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

45.6
Sample id Sample description nTPM
Anterior cingulate gyrus, pregenual-dorsal
nTPM: 41.7
1516 Female, age 85, left hemisphere 53.7
1514 Male, age 74, right hemisphere 44.1
1510 Male, age 61, left hemisphere 42.8
1517 Female, age 67, left hemisphere 42.4
1511 Male, age 61, right hemisphere 41.9
1513 Male, age 74, left hemisphere 40.4
1512 Male, age 75, left hemisphere 40.2
1518 Female, age 67, right hemisphere 39.4
1515 Female, age 94, right hemisphere 30.6
Anterior cingulate gyrus, pregenual-ventral
nTPM: 45.6
1519 Male, age 61, left hemisphere 54.6
1521 Male, age 74, left hemisphere 49.5
1523 Female, age 67, left hemisphere 46.0
1522 Male, age 74, right hemisphere 39.7
1520 Male, age 75, right hemisphere 38.0
Anterior cingulate gyrus, subgenual
nTPM: 44.7
1529 Female, age 85, left hemisphere 57.3
1527 Male, age 74, left hemisphere 48.3
1528 Male, age 74, right hemisphere 46.0
1525 Male, age 75, left hemisphere 45.2
1524 Male, age 61, left hemisphere 42.6
1526 Male, age 75, right hemisphere 37.7
1530 Female, age 67, right hemisphere 36.0
Dorsolateral prefrontal cortex
nTPM: 36.0
1450 Female, age 67, right hemisphere 43.8
1446 Male, age 74, right hemisphere 41.5
1445 Male, age 75, right hemisphere 39.9
1444 Male, age 75, left hemisphere 37.8
1449 Female, age 85, right hemisphere 34.7
1447 Female, age 94, left hemisphere 28.1
1448 Female, age 94, right hemisphere 26.4
Dorsomedial prefrontal cortex
nTPM: 41.1
1442 Male, age 75, right hemisphere 56.3
1441 Male, age 75, left hemisphere 44.8
1440 Male, age 61, right hemisphere 40.9
1443 Female, age 67, right hemisphere 33.5
1439 Male, age 61, left hemisphere 30.1
Frontomarginal cortex
nTPM: 33.1
1466 Male, age 61, right hemisphere 44.8
1465 Male, age 61, left hemisphere 42.9
1472 Female, age 67, left hemisphere 38.9
1467 Male, age 75, right hemisphere 36.1
1468 Male, age 74, left hemisphere 35.1
1473 Female, age 67, right hemisphere 31.0
1469 Female, age 94, left hemisphere 29.1
1470 Female, age 94, right hemisphere 21.5
1471 Female, age 85, left hemisphere 18.0
Frontopolar cortex
nTPM: 33.7
1459 Male, age 61, right hemisphere 44.5
1458 Male, age 61, left hemisphere 40.4
1463 Female, age 67, left hemisphere 36.4
1460 Male, age 75, left hemisphere 35.7
1462 Female, age 94, left hemisphere 29.5
1461 Male, age 75, right hemisphere 26.8
1464 Female, age 67, right hemisphere 22.9
Gyrus rectus
nTPM: 33.5
1475 Male, age 61, right hemisphere 42.6
1474 Male, age 61, left hemisphere 41.4
1479 Female, age 94, right hemisphere 35.1
1476 Male, age 75, left hemisphere 34.2
1477 Male, age 75, right hemisphere 33.1
1480 Female, age 85, left hemisphere 32.4
1481 Female, age 67, left hemisphere 25.5
1478 Female, age 94, left hemisphere 23.8
Inferior frontal gyrus, orbital
nTPM: 39.8
1507 Female, age 85, left hemisphere 51.0
1504 Male, age 74, left hemisphere 48.0
1508 Female, age 85, right hemisphere 46.9
1502 Male, age 75, left hemisphere 44.1
1503 Male, age 75, right hemisphere 43.7
1500 Male, age 61, left hemisphere 40.9
1509 Female, age 67, right hemisphere 35.7
1506 Female, age 94, left hemisphere 31.8
1505 Male, age 74, right hemisphere 31.5
1501 Male, age 61, right hemisphere 24.6
Inferior frontal gyrus, triangular
nTPM: 40.1
1545 Male, age 74, right hemisphere 49.0
1543 Male, age 61, right hemisphere 45.6
1542 Male, age 61, left hemisphere 42.7
1544 Male, age 75, right hemisphere 41.9
1548 Female, age 85, right hemisphere 38.6
1549 Female, age 67, left hemisphere 36.0
1547 Female, age 85, left hemisphere 33.6
1546 Female, age 94, right hemisphere 33.2
Orbitofrontal gyrus, lateral
nTPM: 38.8
1498 Female, age 85, right hemisphere 45.4
1497 Female, age 85, left hemisphere 44.2
1494 Male, age 75, left hemisphere 42.7
1493 Male, age 61, right hemisphere 41.7
1499 Female, age 67, right hemisphere 35.0
1496 Female, age 94, right hemisphere 32.5
1495 Female, age 94, left hemisphere 30.3
Orbitofrontal gyrus, medial
nTPM: 30.2
1490 Female, age 85, right hemisphere 35.3
1489 Female, age 85, left hemisphere 34.2
1491 Female, age 67, left hemisphere 34.1
1483 Male, age 75, left hemisphere 33.7
1486 Male, age 74, right hemisphere 32.5
1492 Female, age 67, right hemisphere 31.9
1488 Female, age 94, right hemisphere 28.0
1484 Male, age 75, right hemisphere 27.2
1482 Male, age 61, left hemisphere 26.5
1485 Male, age 74, left hemisphere 24.9
1487 Female, age 94, left hemisphere 23.6
Orbitofrontal gyrus, posterior
nTPM: 41.9
1533 Male, age 75, left hemisphere 46.6
1538 Female, age 85, left hemisphere 46.1
1532 Male, age 61, right hemisphere 45.3
1531 Male, age 61, left hemisphere 45.0
1535 Male, age 74, left hemisphere 44.8
1541 Female, age 67, right hemisphere 42.6
1540 Female, age 67, left hemisphere 40.4
1534 Male, age 75, right hemisphere 40.0
1536 Female, age 94, left hemisphere 39.3
1539 Female, age 85, right hemisphere 38.2
1537 Female, age 94, right hemisphere 32.8
Subcallosal gyrus
nTPM: 38.1
1551 Male, age 61, right hemisphere 50.3
1558 Female, age 85, left hemisphere 46.9
1554 Male, age 74, left hemisphere 40.8
1550 Male, age 61, left hemisphere 39.9
1559 Female, age 85, right hemisphere 39.9
1560 Female, age 67, left hemisphere 39.7
1555 Male, age 74, right hemisphere 39.6
1552 Male, age 75, left hemisphere 39.1
1553 Male, age 75, right hemisphere 35.6
1561 Female, age 67, right hemisphere 31.7
1557 Female, age 94, right hemisphere 29.0
1556 Female, age 94, left hemisphere 25.0
Superior frontal gyrus
nTPM: 37.3
1563 Male, age 61, right hemisphere 43.4
1569 Female, age 85, left hemisphere 43.0
1565 Male, age 75, right hemisphere 42.0
1570 Female, age 85, right hemisphere 41.4
1564 Male, age 75, left hemisphere 40.5
1571 Female, age 67, right hemisphere 39.8
1566 Male, age 74, right hemisphere 38.2
1562 Male, age 61, left hemisphere 34.5
1568 Female, age 94, right hemisphere 25.2
1567 Female, age 94, left hemisphere 24.6
Temporal cortex
nTPM: 35.4
1592 Male, age 74, left hemisphere 40.9
1593 Male, age 74, right hemisphere 39.5
1591 Male, age 75, right hemisphere 39.0
1596 Female, age 85, right hemisphere 33.1
1595 Female, age 94, right hemisphere 33.0
1590 Male, age 61, right hemisphere 32.6
1594 Female, age 94, left hemisphere 29.8
Ventrolateral prefrontal cortex
nTPM: 34.0
1455 Female, age 85, right hemisphere 39.0
1457 Female, age 67, right hemisphere 36.9
1451 Male, age 75, right hemisphere 35.6
1452 Male, age 74, left hemisphere 35.5
1453 Male, age 74, right hemisphere 32.8
1454 Female, age 94, left hemisphere 30.6
1456 Female, age 67, left hemisphere 27.6
Ventromedial prefrontal cortex
nTPM: 36.3
1436 Female, age 85, left hemisphere 55.9
1437 Female, age 85, right hemisphere 37.1
1438 Female, age 67, left hemisphere 35.0
1433 Male, age 61, right hemisphere 34.5
1434 Male, age 75, right hemisphere 31.8
1435 Female, age 94, right hemisphere 31.8
1432 Male, age 61, left hemisphere 27.9

CEREBRAL CORTEX - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

191.9
FANTOM5 sample id Sample description Scaled Tags Per Million
Occipital cortex
Scaled Tags Per Million: 108.2
FF:10163-103B1 76 years, female 108.2
Postcentral gyrus
Scaled Tags Per Million: 169.9
FF:10032-101E5 44-52 years, mixed 169.9
Frontal lobe
Scaled Tags Per Million: 145.6
FF:10040-101F4 32-61 years, mixed 145.6
Insula
Scaled Tags Per Million: 179.6
FF:10039-101F3 20-68 years, mixed 179.6
Medial frontal gyrus
Scaled Tags Per Million: 114.9
FF:10150-102I6 76 years, female 114.9
Medial temporal gyrus
Scaled Tags Per Million: 102.5
FF:10183-103D3 60 years, female 103.1
FF:10156-103A3 76 years, female 101.9
Occipital lobe
Scaled Tags Per Million: 131.1
FF:10076-102A4 27 years, male 131.1
Occipital pole
Scaled Tags Per Million: 191.9
FF:10036-101E9 22-68 years, mixed 191.9
Paracentral gyrus
Scaled Tags Per Million: 149.7
FF:10035-101E8 22-69 years, mixed 149.7
Parietal lobe
Scaled Tags Per Million: 111.9
FF:10034-101E7 35-89 years, mixed 149.2
FF:10157-103A4 76 years, female 103.0
FF:10171-103B9 60 years, female 83.6
Temporal lobe
Scaled Tags Per Million: 183.9
FF:10031-101E4 32-61 years, mixed 183.9

CEREBRAL CORTEX - Macaque RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

123.9
Macaque sample Sample description nTPM
Angular gyrus
nTPM: 75.3
Samples: 1

Max nTPM: 75.3
Min nTPM: 75.3
Sample A 75.3
Claustrum
nTPM: 122.9
Samples: 1

Max nTPM: 122.9
Min nTPM: 122.9
Sample B 122.9
Fusiform gyrus
nTPM: 122.0
Samples: 2

Max nTPM: 163.5
Min nTPM: 80.4
Sample A 80.4
Sample B 163.5
Inferior temporal gyrus
nTPM: 96.6
Samples: 2

Max nTPM: 98.6
Min nTPM: 94.6
Sample A 94.6
Sample B 98.6
Middle temporal gyrus
nTPM: 101.3
Samples: 2

Max nTPM: 112.1
Min nTPM: 90.4
Sample A 112.1
Sample B 90.4
Postcentral gyrus
nTPM: 92.2
Samples: 2

Max nTPM: 99.2
Min nTPM: 85.1
Sample A 85.1
Sample B 99.2
Posterior cingulate cortex
nTPM: 108.4
Samples: 2

Max nTPM: 113.5
Min nTPM: 103.2
Sample A 103.2
Sample B 113.5
Precentral gyrus
nTPM: 114.9
Samples: 3

Max nTPM: 143.6
Min nTPM: 93.8
Sample A 93.8
Sample B 107.3
Sample C 143.6
Superior parietal lobule
nTPM: 88.8
Samples: 2

Max nTPM: 93.3
Min nTPM: 84.2
Sample A 84.2
Sample B 93.3
Superior temporal gyrus
nTPM: 94.8
Samples: 2

Max nTPM: 107.8
Min nTPM: 81.7
Sample A 81.7
Sample B 107.8
Supramarginal gyrus
nTPM: 104.4
Samples: 2

Max nTPM: 117.3
Min nTPM: 91.6
Sample A 91.6
Sample B 117.3
Gyrus rectus
nTPM: 123.9
Samples: 2

Max nTPM: 130.7
Min nTPM: 117.2
Sample A 117.2
Sample B 130.7
Insular cortex
nTPM: 116.6
Samples: 2

Max nTPM: 122.7
Min nTPM: 110.5
Sample A 122.7
Sample B 110.5
Superior frontal gyrus
nTPM: 122.1
Samples: 2

Max nTPM: 137.2
Min nTPM: 106.9
Sample A 106.9
Sample B 137.2

CEREBRAL CORTEX - Pig RNA-seqi

RNA-seq data obtained from pig brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

120.9
Pig sample Sample description nTPM
Occipital cortex
nTPM: 108.8
Samples: 4

Max nTPM: 140.4
Min nTPM: 92.2
Sample A Female 106.9
Sample B Female 92.2
Sample C Male 140.4
Sample D Male 95.8
Retrosplenial cortex
nTPM: 102.4
Samples: 4

Max nTPM: 125.9
Min nTPM: 90.3
Sample A Female 90.3
Sample B Female 96.0
Sample C Male 125.9
Sample D Male 97.2
Cingulate cortex
nTPM: 102.6
Samples: 4

Max nTPM: 112.5
Min nTPM: 95.6
Sample A Female 105.3
Sample B Female 96.9
Sample C Male 112.5
Sample D Male 95.6
Insular cortex
nTPM: 119.1
Samples: 4

Max nTPM: 129.5
Min nTPM: 102.5
Sample A Female 124.3
Sample B Female 102.5
Sample C Male 129.5
Sample D Male 120.0
Motor cortex
nTPM: 116.0
Samples: 4

Max nTPM: 125.6
Min nTPM: 97.6
Sample A Female 125.6
Sample B Female 118.3
Sample C Male 122.4
Sample D Male 97.6
Prefrontal cortex
nTPM: 120.9
Samples: 4

Max nTPM: 130.7
Min nTPM: 115.2
Sample A Female 130.7
Sample B Female 118.9
Sample C Male 118.6
Sample D Male 115.2
Somatosensory cortex
nTPM: 118.6
Samples: 3

Max nTPM: 121.5
Min nTPM: 115.7
Sample B Female 115.7
Sample C Male 118.5
Sample D Male 121.5
Temporal cortex
nTPM: 108.9
Samples: 3

Max nTPM: 140.1
Min nTPM: 92.0
Sample A Female 94.6
Sample B Female 140.1
Sample D Male 92.0

CEREBRAL CORTEX - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

186.0
Mouse sample Sample description nTPM
Motor and prefrontal cortex
nTPM: 184.9
Samples: 4

Max nTPM: 231.5
Min nTPM: 155.4
Sample A 156.1
Sample B 155.4
Sample C 196.7
Sample D 231.5
Retrosplenial and cingulate cortex
nTPM: 186.0
Samples: 3

Max nTPM: 192.7
Min nTPM: 181.6
Sample A 181.6
Sample B 192.7
Sample C 183.8
Somatosensory cortex
nTPM: 156.7
Samples: 4

Max nTPM: 196.6
Min nTPM: 141.8
Sample A 196.6
Sample B 143.9
Sample C 144.3
Sample D 141.8
Visual cortex
nTPM: 173.8
Samples: 4

Max nTPM: 197.7
Min nTPM: 145.7
Sample A 171.9
Sample B 197.7
Sample C 180.0
Sample D 145.7

CEREBRAL CORTEX - Rat RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

123.5
Rat sample Sample description nTPM
Occipital cortex
nTPM: 123.5
Samples: 4

Max nTPM: 125.0
Min nTPM: 122.0
Sample A 123.9
Sample A 125.0
Sample A 122.0
Sample A 123.0
Retrosplenial and cingulate cortex
nTPM: 110.5
Samples: 4

Max nTPM: 113.3
Min nTPM: 109.0
Sample A 113.3
Sample A 109.6
Sample B 110.1
Sample A 109.0
Somatosensory cortex
nTPM: 115.1
Samples: 4

Max nTPM: 119.5
Min nTPM: 108.1
Sample A 114.7
Sample A 119.5
Sample A 118.0
Sample A 108.1

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