ENSG00000291316
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BETA
  • SUMMARY

  • TISSUE

  • BRAIN

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  • IMMUNE

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  • EVOLUTION

  • ENSG00000291316
EVOLUTIONARY MIDBRAIN Show tissue menu
BRAIN60 EYE4 ENDOCRINE TISSUES4 RESPIRATORY SYSTEM6 PROXIMAL DIGESTIVE TRACT5 GASTROINTESTINAL TRACT11 LIVER & GALLBLADDER4 PANCREAS1 KIDNEY & URINARY BLADDER4 MALE REPRODUCTIVE SYSTEM10 BREAST & FEMALE REPRODUCTIVE SYSTEM9 MUSCLE & VASCULAR TISSUE11 CONNECTIVE & SOFT TISSUE14 SKIN4 BONE MARROW & LYMPHOID TISSUES7
Select an organ to show its tissues
AMYGDALA ANGULAR GYRUS ANNECTANT GYRUS ANTERIOR CINGULATE GYRUS CAUDATE NUCLEUS CAUDATE PUTAMEN CEREBELLUM CEREBRAL CORTEX CHOROID PLEXUS CLAUSTRUM CUNEUS DORSAL ROOT GANGLION DORSAL SPINAL CORD ENTORHINAL CORTEX FUSIFORM GYRUS
GENICULATE NUCLEUS GLOBUS PALLIDUS GYRUS RECTUS HABENULA HIPPOCAMPAL FORMATION HYPOTHALAMUS HYPOTHALAMUS, ANTERIOR HYPOTHALAMUS, POSTERIOR INFERIOR FRONTAL GYRUS INFERIOR OCCIPITAL GYRUS INFERIOR TEMPORAL GYRUS INSULAR CORTEX LATERAL THALAMIC NUCLEI MEDULLA OBLONGATA MIDBRAIN
MIDDLE FRONTAL GYRUS MIDDLE TEMPORAL GYRUS MOTOR AND PREFRONTAL CORTEX OCCIPITAL GYRUS OLFACTORY BULB ORBITAL GYRUS PONS POSTCENTRAL GYRUS POSTERIOR CINGULATE CORTEX POSTERIOR PARAHIPPOCAMPAL GYRUS POSTERIOR THALAMUS PRECENTRAL GYRUS PREOPTIC AREA PUTAMEN RETROSPLENIAL AND CINGULATE CORTEX
SEPTUM SOMATOSENSORY CORTEX SPINAL CORD SUBICULUM SUBSTANTIA NIGRA SUPERIOR COLLICULI SUPERIOR FRONTAL GYRUS SUPERIOR PARIETAL LOBULE SUPERIOR TEMPORAL GYRUS SUPRAMARGINAL GYRUS THALAMUS VENTRAL FOREBRAIN VENTRAL SPINAL CORD VISUAL CORTEX WHITE MATTER
CORNEA HARDERIAN GLAND LENS RETINA
ADRENAL GLAND PARATHYROID GLAND PITUITARY GLAND THYROID GLAND
BRONCHUS LARYNX LUNG NASOPHARYNX OLFACTORY EPITHELIUM TRACHEA
ESOPHAGUS LIP ORAL MUCOSA SALIVARY GLAND TONGUE
CECUM COLON DUODENUM ILEUM JEJUNUM RECTUM SMALL INTESTINE STOMACH STOMACH (LOWER) STOMACH (MIDDLE) STOMACH (UPPER)
GALLBLADDER LIVER LIVER (LOBE 1) LIVER (LOBE 4)
PANCREAS
KIDNEY KIDNEY (CORTEX) KIDNEY (MEDULLA) URINARY BLADDER
BULBOURETHRAL GLAND DUCTUS DEFERENS EPIDIDYMIS MALE PREPUTIAL GLAND PENIS PROSTATE PROSTATE (ANTERIOR) PROSTATE (VENTRAL) SEMINAL VESICLE TESTIS
BREAST CERVIX CLITORIS ENDOMETRIUM FALLOPIAN TUBE OVARY PLACENTA UTERUS VAGINA
AORTA DIAPHRAGM HEART ATRIUM HEART MUSCLE HEART VALVE HEART WALL PERIPHERAL VASCULATURE SKELETAL MUSCLE SMOOTH MUSCLE SMOOTH MUSCLE (INTESTINE) SMOOTH MUSCLE (UTERUS)
ABDOMINAL ADIPOSE TISSUE ADIPOSE TISSUE BROWN ADIPOSE TISSUE DURA MATER EAR CANAL EAR CARTILAGE JOINT CARTILAGE ORBITAL ADIPOSE TISSUE PERICARDIUM PERITONEUM PLEURA SUBCUTANEOUS ADIPOSE TISSUE SYNOVIAL TISSUE VAGUS NERVE
EYE LID SKIN SKIN (BACK) SKIN (GROIN)
APPENDIX BLOOD, PBMC BONE MARROW LYMPH NODE SPLEEN THYMUS TONSIL
HumanMacaqueMouseRatPig
Protein evolution
Brain
Evolutionary methods
MIDBRAIN - Expression summary
Protein expressioni

On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). Underneath, protein expression in each annotated cell type are reported using the same units. Protein expression data is based on knowledge-based annotation. For genes where more than one antibody has been used, a collective score is set. If knowledge-based annotation could not be performed for a gene, no data is displayed here. View antibody staining data further down this page.

No data
RNA expressioni

A summary of mRNA expression data available for current tissue based on several datasets. The mRNA expression levels in human tissues are based on RNA-seq data generated by the Human Protein Atlas HPA, Genotype-Tissue Expression GTEx portal and CAGE data generated by the FANTOM5 consortium. Consensus normalized expression levels for human tissues was created by combining the data from HPA and GTEx datasets. The mRNA expression levels in pig brain are based on RNA-seq data generated by the Human Protein Atlas, and for mouse brain HPA data and in situ hybridization generated by the Allen brain atlas dataset are reported.

Scroll down to view mRNA expression data in more detail.

HPA Brain:13.3 nTPM
FANTOM5:22.4 Scaled Tags Per Million
Macaque:31.0 nTPM
Mouse:31.8 nTPM

MIDBRAIN - HPA Brain RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

13.3
Sample id Sample description nTPM
Cuneiform nucleus
nTPM: 12.1
2586 Male, age 75, left hemisphere 19.4
1827 Male, age 72, unknown 13.7
2828 Female, age 72, unknown 12.2
2666 Male, age 74, left hemisphere 12.1
2019 Male, age 18, unknown 11.1
1833 Male, age 53, unknown 10.9
2219 Male, age 76, both hemispheres 10.8
2411 Female, age 72, unknown 10.8
1830 Male, age 51, unknown 10.6
1870 Female, age 42, unknown 9.7
Dorsal raphe nucleus
nTPM: 11.6
2298 Female, age 72, unknown 14.0
2047 Male, age 72, unknown 12.5
1828 Male, age 53, unknown 11.8
2016 Female, age 72, unknown 10.4
2750 Male, age 76, both hemispheres 9.4
Inferior colliculus
nTPM: 11.5
2849 Male, age 72, unknown 13.0
1848 Female, age 42, unknown 12.5
2097 Female, age 72, unknown 11.3
1890 Male, age 53, unknown 9.3
Median raphe nucleus
nTPM: 12.4
2220 Male, age 76, midline 12.4
Periaquaductal grey, anterior
nTPM: 11.1
2502 Female, age 75, unknown 12.9
1947 Male, age 18, unknown 10.7
1795 Male, age 51, unknown 9.8
Periaquaductal grey, dorsal
nTPM: 13.3
1840 Male, age 53, unknown 15.7
1831 Male, age 72, unknown 14.2
2850 Male, age 76, both hemispheres 11.6
2464 Female, age 72, unknown 11.5
Periaquaductal grey, lateral
nTPM: 11.4
2053 Male, age 18, unknown 13.5
2272 Male, age 74, both hemispheres 11.0
2140 Male, age 76, both hemispheres 9.7
Pretectal area
nTPM: 12.3
1816 Male, age 51, unknown 16.9
1817 Female, age 42, unknown 16.6
1944 Female, age 72, unknown 13.1
2825 Male, age 18, unknown 13.1
1815 Male, age 53, unknown 12.5
2224 Female, age 72, unknown 11.7
2407 Male, age 75, both hemispheres 11.3
2667 Female, age 75, unknown 11.1
2007 Male, age 72, unknown 10.6
2316 Male, age 76, right hemisphere 9.9
2273 Male, age 74, both hemispheres 8.9
Red nucleus
nTPM: 9.9
1821 Female, age 72, unknown 12.0
1865 Male, age 51, unknown 11.3
2588 Male, age 74, left hemisphere 11.2
2584 Male, age 75, left hemisphere 11.1
2823 Male, age 76, right hemisphere 10.3
2503 Female, age 72, unknown 10.2
1904 Male, age 53, unknown 10.1
1954 Female, age 42, unknown 9.6
2227 Male, age 72, unknown 9.6
2725 Female, age 75, unknown 9.1
2785 Male, age 18, unknown 8.3
2769 Male, age 72, unknown 6.2
Substantia nigra
nTPM: 12.5
1916 Female, age 42, unknown 14.2
2241 Male, age 72, unknown 14.2
2665 Male, age 74, both hemispheres 13.6
2699 Male, age 18, unknown 13.2
1851 Male, age 51, unknown 12.8
2583 Male, age 75, right hemisphere 12.1
2590 Female, age 75, unknown 11.7
1889 Female, age 72, unknown 11.5
1941 Male, age 53, unknown 10.9
2409 Female, age 72, unknown 10.4
Superior colliculus
nTPM: 12.1
2087 Female, age 72, unknown 14.9
1796 Male, age 53, unknown 14.4
2664 Male, age 75, both hemispheres 13.2
2668 Female, age 75, unknown 12.8
1995 Male, age 72, unknown 12.2
2261 Male, age 18, unknown 11.3
1839 Male, age 51, unknown 11.1
1913 Female, age 42, unknown 10.9
2587 Male, age 74, left hemisphere 9.9
1895 Male, age 76, right hemisphere 9.7
Ventral tegmental area
nTPM: 12.5
2410 Female, age 72, unknown 15.5
2218 Male, age 76, both hemispheres 15.1
2021 Male, age 53, unknown 12.1
2223 Female, age 72, unknown 11.5
1915 Female, age 42, unknown 10.9
1942 Male, age 51, unknown 10.1

MIDBRAIN - FANTOM5 CAGEi

RNA expression in human tissues obtained through Cap Analysis of Gene Expression (CAGE) generated by the FANTOM5 project are reported as Scaled Tags Per Million.

Max subtype Scaled Tags Per Millioni

Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.

22.4
FANTOM5 sample id Sample description Scaled Tags Per Million
Substantia nigra
Scaled Tags Per Million: 22.4
FF:10158-103A5 76 years, female 22.4

MIDBRAIN - Macaque RNA-seq
Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

31.0
Macaque sample Sample description nTPM
Substantia nigra
nTPM: 24.7
Samples: 1

Max nTPM: 24.7
Min nTPM: 24.7
Sample A 24.7
Midbrain
nTPM: 26.0
Samples: 1

Max nTPM: 26.0
Min nTPM: 26.0
Sample A 26.0
Superior colliculi
nTPM: 31.0
Samples: 1

Max nTPM: 31.0
Min nTPM: 31.0
Sample A 31.0

MIDBRAIN - Mouse RNA-seqi

RNA-seq data obtained from mouse brain is reported as nTPM. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. nTPM values of the individual samples are presented next to the box plot.

Max subtype nTPMi

Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.

31.8
Mouse sample Sample description nTPM
Midbrain
nTPM: 31.8
Samples: 4

Max nTPM: 33.2
Min nTPM: 30.3
Sample A 30.3
Sample B 33.2
Sample C 32.8
Sample D 31.0

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