Proteins detected in plasma using proximity extension assay
Proximity extension assays (PEA) based on Olink was performed for 1456 proteins based on a longitudinal wellness study covering 76 individuals for two years with three visits at month 0, month 18 and month 24 (visits 1-3). The results are presented as Normalized Protein eXpression (NPX) for the individual genes corresponding to these proteins for all females and males respectively.
Below is a summary of the variation between individuals and within individuals for these 1456 proteins calculated as the mean coefficient of variation (CV) for each protein within each visit and across all analyzed individuals (n=76), and as the mean CV for each protein within each individual across all three visits respectively.
Figure 1 Protein profiles of Leptin shown with the individual concentrations across three visits over two years and the median levels for males and females, respectively.
Figure 2 A summary of the results for females and males as "violin" plots showing the distribution of protein levels of Leptin across the individuals for each visit. These plots are shown for all the 1456 proteins on respective gene page accessed though the links in the Table above.