Brain expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in.	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function.	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	Neurons	Mixed function	348	Medium
2	Neurons	Nucleosome	199	Medium
3	Choroid plexus	Cilium	205	Medium
4	Non-specific	mRNA splicing & Cell cycle	198	Low
5	Non-specific	Mixed function	50	Low
6	Non-specific	Immune response	524	Low
7	Non-specific	Ribosome	142	Medium
8	Immune cells	Immune response	183	Low
9	Non-specific	Receptor signaling	275	Medium
10	Cerebellum	Nucleic acid binding	343	Medium
11	White matter	Signal transduction	593	Medium
12	Non-specific	Vasculature	293	Low
13	Oligodendrocytes	Mixed function	308	Low
14	Neurons	Synaptic function	515	Medium
15	Non-specific	Transcription	490	Medium
16	Non-specific	Transcription	188	Medium
17	Choroid plexus	Cilium	190	Medium
18	Non-specific	Mixed function	61	Low
19	Astrocytes	Mixed function	451	Low
20	Macrophages & Microglia	Immune response	449	Medium
21	Non-specific	Metabolism	571	Low
22	Non-specific	Mixed function	56	Low
23	Choroid plexus	Mixed function	469	Low
24	Neurons	Mixed function	192	Low
25	Non-specific	Transcription	477	Low
26	Oligodendrocytes	Mixed function	150	Low
27	Non-specific	Mixed function	382	Low
28	Oligodendrocytes	Mixed function	601	Low
29	Forebrain	Mixed function	202	Low
30	White matter	Myelination	403	High
31	Non-specific	Transcription	461	Medium
32	Cerebral cortex	Mixed function	292	Low
33	Neurons	Mixed function	268	Low
34	Non-specific	Mixed function	433	Low
35	Non-specific	DNA binding	251	Low
36	Choroid plexus	Mixed function	219	Low
37	Neurons	Mixed function	337	Low
38	Sub-cortical	Mixed function	321	Low
39	Astrocytes	Mixed function	325	Medium
40	Astrocytes	Astrocyte-neuron interactions	369	Medium
41	Monoamines	Neurotransmitter signalling	231	High
42	Choroid plexus	Mitochondria	295	Low
43	Hindbrain	Mixed function	178	Medium
44	Non-specific	Mixed function	394	Low
45	Non-specific	Mixed function	225	Low
46	Brainstem	Mixed function	237	Low
47	Endothelial cells	Vasculature	221	Medium
48	Non-specific	Mixed function	355	Low
49	Hindbrain	Mixed function	266	Low
50	Non-specific	Nucleic acid binding	273	Low
51	Neurons	Mixed function	530	Low
52	Neurons & Synapses	Synaptic function	419	Medium
53	Neurons	Mixed function	527	Low
54	Immune cells	T cell receptor	58	High
55	Non-specific	Transcription	445	Low
56	Hypothalamus	Neuropeptide signaling	394	High

The interactive UMAP plot displays the 56 gene clusters resulting from Louvain clustering of gene expression across all tissue types. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all tissue types for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.

Blood & immune cells
Endocrine cells
Endothelial cells
Glial cells
Neuronal cells
Other
Non-Specific