Single cell type expression cluster

e.g. Metabolic proteins, Localized to mitochondria, Genes tissue enriched in brain (RNA)

Field

Cluster

Cell type

Category

Cluster

Pathway

IDⁱ The ID of each cluster.	Main specificityⁱ The annotated specificity of the cluster. This annotation aims to reflect which type of tissues or cell types the genes of the cluster show elevated expression in.	Main functionⁱ The annotated function of the cluster, based on an overrepresentation of genes associated with the annotated function.	# Genesⁱ Number of genes in the cluster.	Annotation reliabilityⁱ The annotation reliability is manually set for all clusters and indicates the level of reliability of the annotated specificity and function.
1	Enterocytes	Absorption and Digestion	148	High
2	Cerebellar granular cells	Neuronal signaling	130	High
3	Early primary spermatocytes	Early meiosis	153	High
4	Breast lactating luminal cells	Lactation	44	Medium
5	Pancreatic acinar cells	Pancreatic exocrine secretion	35	High
6	Plasmacytoid dendritic cells	Viral sensing & interferon response	79	High
7	Non-specific	Transcription	487	High
8	Non-specific	Secretory pathway	119	Medium
9	T-cells	Adaptive immunity: Regulation	281	High
10	Epididymal principal cells	Sperm maturation microenvironment	92	High
11	Muller glia cells	Retinal homeostasis	80	High
12	Endothelial cells	Angiogenesis & vascular homeostasis	216	High
13	Syncytiotrophoblasts	Placental remodeling & endocrine func.	65	High
14	Oligodendrocyte progenitor cells	Development & myelination	97	High
15	Non-specific	Protein processing	232	High
16	Prostatic glandular cells	Androgen response & seminal fluid	90	High
17	Non-specific	RNA processing	457	High
18	Adrenal cortex cells	Steroidogensis	86	High
19	Cerebellar purkinje cells	Neurotransmission & signaling	47	Medium
20	Non-specific	Transcription regulation	139	Medium
21	Extravillous trophoblasts	Placental invasion & endocrine regulatio	92	High
22	Non-specific	Basic cellular functions	156	Low
23	Elongating spermatids	Sperm cell metabolism & fertilization	306	Medium
24	Neutrophils	Innate immunity signal integration	352	Medium
25	Hepatocytes	Plasma protein synthesis & secretion	129	High
26	Keratinocytes	Keratinization	102	High
27	Non-specific	Cell proliferation	244	High
28	Astrocytes	Homeostasis & neuron support	158	High
29	Neutrophils	Innate immune cellular maintenance	342	Medium
30	Epididymal principal cells	Sperm storage microenvironment	84	High
31	Neutrophils	Chemotaxis & Apoptosis	311	Medium
32	Endothelial cells	Angiogenesis & vascular immunity	373	High
34	Ciliated cells	Cilia assembly & function	209	High
35	Neurons	Synaptic function & neurogenesis	348	High
36	Skeletal myocytes	Muscle excitation & contraction	183	High
37	Neutrophil progenitors	Granulopoiesis	242	High
38	Secretory epithelial cells	Exocrine secretion	178	Medium
39	Syncytiotrophoblasts	Placental homeostasis & endocrine signal	189	High
40	Monocytes & Neutrophils	Inflammatory signaling	283	High
41	Oocytes	Oogenesis	74	High
42	Early spermatids	Spermiogenesis: Acrosomal phase	250	High
43	Sertoli cells	Spermatogenesis microenvironment	81	High
44	Plasma cells	Antibody production & secretion	129	High
45	Colonocytes & Enterocytes	Gastrointestinal absorption & barrier	320	High
46	Skeletal myocytes	Muscle structure & formation	184	High
47	Platelets	Hemostasis	204	High
48	Neutrophils	Phagocytosis & degranulation	329	High
49	Apical squamous epithelium	Epithelial barrier & keratinization	130	High
50	Renal epithelial cells	Ion transport and pH regulation	155	High
51	Secretory epithelial cells	Mixed function	223	Medium
52	Glandular & Luminal cells	Estrogen-regulated epithelial secretion	120	Medium
53	Late primary spermatocytes	Meiotic division & transition	303	High
54	Intestinal epithelial cells	Intestinal epi homeostasis & respiration	107	Medium
55	Myocytes	Oxidative muscle function	145	High
56	Late spermatids	Spermiogenesis: Maturation	234	Medium
57	Podocytes	Glomerular filtration	56	High
58	Mast cells	Allergic inflammatory responses	80	High
59	Pituitary endocrine cells	Neuroendocrine signaling	213	High
60	Cardiomyocytes	Cardiac muscle contraction & structure	246	High
61	Schwann cells & Melanocytes	Mixed function	52	Low
62	Smooth muscle cells	Muscle contraction	172	High
63	Cytotrophoblasts	Basic cellular functions	220	Medium
64	Renal epithelial cells	Ion transport & homeostasis	105	Medium
65	Non-specific	Cell growth & division	117	Medium
66	Erythroid cells	Erythroid differentiation and maturation	145	Medium
67	Plasma cells	Plasma cell differentiation	116	Medium
68	Foveolar cells	Mucosal defense	65	Medium
69	Urothelial cells	Basic cellular functions	117	High
70	Intestinal goblet cells	Mucin production	92	High
71	Non-specific	Cardiac endocrine signaling & maintenanc	353	Medium
72	Macrophages	Phagocytosis & lysosomal degradation	247	High
73	Late spermatids	Spermiogenesis: Maturation	139	Medium
74	Microglia	Neuroimmunity & neuroinflammation	118	High
75	Non-specific	Chaperones and protein folding	37	Medium
76	Pancreatic endocrine cells	Endocrine signaling	102	High
77	Late primary spermatocytes	Spermiogenesis: Golgi Phase	126	High
78	Plasma cells	Antibody production & ER-stress response	76	High
79	Photoreceptor cells	Phototransduction	275	High
80	Oligodendrocytes	Myelination	134	High
81	Alveolar cells	Lung function	64	High
82	Dendritic cells	Antigen presentation	172	High
83	Epicardial mesothelial cells	Basic cellular functions	118	Medium
84	Apical squamous epithelium	Cornification	157	High
85	Squamous epithelial cells	Keratinization	194	High
86	Retinal bipolar cells	Synaptic signal transduction	272	High
87	B-cells	Adaptive immunity: Humoral response	200	High
88	Proximal tubular cells	Transmembrane transport	157	High
89	Adipocytes	Lipid metabolism	142	High
90	Elongating spermatids	Spermiogenesis: Elongation	154	High
91	Pituicytes/FSC	Homeostasis & neuron support	104	Medium
92	NK-cells & T-cells	Adaptive immunity: Cytotoxicity	312	High
93	Hepatocytes	Bile production & excretion	130	High
94	Gonadal somatic cells	Mixed function	128	Medium
95	Tuft cells	Chemosensory signaling	39	Medium
96	Enteroendocrine cells	Neuropeptide signaling	74	High
97	Non-specific	Cellular respiration	495	High
98	Neurons	Neurotransmission & signaling	318	Medium
99	Retinal pigment epithelial cells	Retinol metabolism	54	Medium
100	Stratified epithelial cells	Barrier functions	150	Medium
101	Choroid plexus epithelial cells	Ion transport	91	High
102	Non-specific	Mixed function	284	Very low
103	Non-specific	Basic cellular processes	199	Medium
104	Brain endothelial cells	Blood brain barrier	74	High
105	Non-specific	Mixed function	131	Low
106	Spermatogonia	Spermatogonial differentiation	115	High
107	Ciliated cells	Cilia assembly & function	203	High
108	Fibroblasts	ECM organization	348	High
110	Mural cells	ECM organization	120	High

The interactive UMAP plot displays the 110 gene clusters resulting from Louvain clustering of gene expression across all single cell types. General information about the different clusters regarding annotation and number of included genes is shown upon mouse-over, while clicking on a specific cluster in the table will highlight the selected cluster in the plot and display the general information together with a heatmap of the RNA expression across all single cell types for corresponding genes and a Gene Ontology treemap showing the enrichment of GO-terms in the cluster, where applicable.

Blood and immune cells
Ciliated cells
Endocrine cells
Endothelial and mural cells
Germ cells
Glandular epithelial cells
Glial cells
Mesenchymal cells
Muscle cells
Neuronal cells
Pigment cells
Specialized epithelial cells
Squamous epithelial cells
Trophoblast cells
Other
Non-Specific