The single cell type resource - Explore the expression profiles in single cell types
This part of the Single cell resource contains Single cell type information based on single cell RNA sequencing (scRNA-seq) and single nuclei RNA sequencing (snRNA-seq) data from 34 human tissue types, including blood. The data is linked to in-house generated immunohistochemically stained tissue sections presented in the Tissue resource in order to visualize the corresponding spatial protein expression patterns. The single cell analysis is based on publicly available genome-wide expression data and comprises all protein-coding genes in 1175 individual cell type clusters corresponding to 15 different cell type classes, and 154 different cell types, this data is also summarised into 53 for classfication and overview. A specificity classification was performed to determine the number of genes elevated in the single cell types, as well as grouped cell types. The genes expressed in each of the cell types can be explored in interactive UMAP plots and bar charts, with links to corresponding immunohistochemical stainings in human tissues.
More information about the specific content, the generation and analysis of the data can be found on the Methods Summary. A cluster comparison between the HPA pipeline and the Tabula Sapiens can be found here.
Learn about:
- mRNA and protein expression in single cell types
- if a gene is enriched in a particular cell type (specificity)
- which genes have a similar expression profile across cell types (expression cluster)
The Human Protein Atlas project is funded
