Protein interactions - SLC25A5 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A5
Synonyms	2F1, ANT2, T2, T3
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Essential proteins FDA approved drug targets Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Colonocytes & Enterocytes - Gastrointestinal absorption & barrier (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Colonocytes, Cytotrophoblasts, Enterocytes, Esophageal basal cells, Esophageal suprabasal cells, Parietal cells, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Stomach - Digestion (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	X
Cytoband	q24
Chromosome location (bp)	119468422 - 119471396
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1
Ensembl	ENSG00000005022 (version 109)
Entrez gene	292
HGNC	HGNC:10991
UniProt	P05141
GeneCards	SLC25A5

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

Filter menu »

e.g. Brain enriched, Localized to mitochondria, Stomach - Digestion

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Non-commercial use only, subject to AlphaFold3 Output Terms of Use

Interaction:

Color scheme:

Confidence

Antibodies

Interactor

Show surface:

Off

Autorotate:

Off

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
SLC25A6	3	13	19	0	59

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
LRRK2	36	108	69	0	0

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACE2	10	13	278	0	0
AIFM1	3	5	139	3	0
ARAF	19	16	65	11	4
ATXN3	3	74	64	1	0
CCNF	4	4	624	0	1
CUL3	40	45	771	2	0
CUL7	6	1	55	3	12
ESR1	34	59	479	0	0
GRB2	82	166	206	3	5
HSPA8	65	45	457	29	101
HUWE1	5	5	209	2	0
MAP2K3	3	5	23	0	0
MYC	66	90	1269	2	0
NPM1	112	30	347	208	0
NTRK1	5	6	134	0	0
PHB1	2	7	130	1	0
PMFBP1	0	1	1	0	0
PRKCZ	10	14	74	0	7
PRKN	11	11	1405	0	0
RC3H1	0	1	134	0	0
RHOA	21	21	121	9	16
RPL4	92	9	147	124	133
RPS3	32	16	144	45	24
SIRT4	1	5	3	0	0
SLC25A31	0	1	2	0	14
SLC25A4	2	3	12	0	40
SLC25A6	3	13	19	0	59
STAU1	32	13	371	39	0
STK4	23	17	947	24	7
TNK2	7	12	36	0	1
TP53	123	166	704	5	0
TUBB	22	18	89	0	82
VCP	57	56	348	43	5
VDAC1	9	15	77	22	2
WWP2	18	52	140	1	1
YAP1	31	32	304	10	0
Show allShow less

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
CAPZB	100	6	133	666	0
RTN4	23	13	45	66	0

Highlight:

Off

Subcell location

Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
SLC25A6	3	13	19	0	59
TBC1D17	1	1	6	0	3

METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene SLC25A5 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol, Mitochondria. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A5-201	P05141		Metabolic proteins Transporters Predicted membrane proteins Plasma proteins FDA approved drug targets Mapped to neXtProt Protein evidence (Kim et al 2014) Essential proteins Protein evidence (Ezkurdia et al 2014) Show all	298 aa 32.9 kDa	No	4