Protein interactions - SLC25A6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A6
Synonyms	ANT3, ANT3Y, MGC17525
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 6
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	FDA approved drug targets Metabolic proteins Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Protein evidence	Evidence at protein level (all genes)

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression analysis and annotation data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Protein processing (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Cell type enhanced (Cytotrophoblasts, Decidual stromal cells, Esophageal basal cells, Migrating cytotrophoblasts, Syncytiotrophoblasts)
Tissue expression cluster (RNA)ⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Non-specific - Protein processing (mainly)
Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected.	Low tissue specificity
Subcellular locationⁱ Main subcellular location based on data generated in the subcellular section of the Human Protein Atlas.	Localized to the Mitochondria
Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes.	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome	X
Cytoband	p22.33
Chromosome location (bp)	1386152 - 1392113
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1
Ensembl	ENSG00000169100 (version 109)
Entrez gene	293
HGNC	HGNC:10992
UniProt	P12236
GeneCards	SLC25A6

ASSAYSⁱ

Interaction

Metabolic

INTERACTIONⁱ

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e.g. Brain enriched, Localized to mitochondria, Non-specific - Protein processing

Field

Cluster

Cell type

Category

Cluster

Pathway

Consensus

IntAct

BioGrid

OpenCell

BioPlex

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Predicted location

Cell type specificity

Protein class

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Interaction:

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Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AP2B1	17	15	70	9	0
SLC25A4	2	3	12	0	40
SLC25A5	1	1	36	2	2

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View all protein interaction data in IntAct

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
AP2B1	17	15	70	9	0
GPAM	0	3	0	0	0
KRT31	19	284	21	0	0
LRRK2	36	108	69	0	0
LZTS2	21	178	46	4	7
MTUS2	3	130	6	0	0
NOTCH2NLA	4	190	9	0	0
SLC25A4	2	3	12	0	40
TEKT4	1	81	2	0	1
TRAF1	17	168	46	0	9
TRIM23	9	142	23	0	0
TRIP6	9	90	24	2	9
VDAC1	9	15	77	22	2
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Predicted location

Cell type specificity

Protein class

Number of interactions:

Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
ACE2	10	13	278	0	0
ANLN	1	0	568	2	0
AP2B1	17	15	70	9	0
ATXN3	3	74	64	1	0
BRD3	0	1	85	0	0
CCNF	4	4	624	0	1
CUL3	40	45	771	2	0
GRB2	82	166	206	3	5
H4C1	32	56	356	0	5
MAD2L2	7	32	145	0	2
MKI67	4	2	39	14	2
MYC	66	90	1269	2	0
NDUFB8	3	0	14	0	11
NTRK1	5	6	134	0	0
PRKN	11	11	1405	0	0
SLC25A4	2	3	12	0	40
SLC25A5	1	1	36	2	2
SOCS2	3	4	59	0	3
STK4	23	17	947	24	7
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Predicted location

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Interaction	# Consensus	# IntAct	# BioGrid	# OpenCell	# BioPlex
A2ML1	0	0	0	1	32
ACP7	0	0	0	0	9
AKR1B10	1	3	1	1	7
ALOX12B	0	1	0	0	30
ANXA8	0	15	0	0	18
ASPRV1	0	0	0	0	4
C3	1	11	5	3	22
CACNG7	0	1	0	0	12
CALML3	2	4	6	3	42
CALML5	1	1	2	0	30
CAPNS2	0	5	0	0	13
CASP14	1	2	6	1	15
CPA4	0	0	0	0	17
CRYAB	9	18	29	0	18
CTSV	0	1	0	3	23
EVPL	0	0	3	1	18
FGB	1	1	4	0	18
FLG	0	1	0	0	17
GLUL	1	2	7	11	28
GM2A	0	2	0	0	19
GPR182	1	1	1	0	243
HAL	0	1	1	0	33
HPGD	0	0	0	0	4
IGHG1	0	1	0	0	35
IGHG2	0	0	0	0	28
IGHG4	0	0	0	1	19
ISLR	0	0	0	0	65
ITGAD	0	0	0	0	25
ITLN1	0	1	0	0	38
IVL	0	2	0	0	31
KLK10	0	0	0	0	115
KLK6	0	100	0	0	12
KLK9	0	0	0	0	4
LGALS7	0	6	1	0	27
LGALS7B	1	6	1	0	27
LRRC25	0	30	1	0	59
LRRN4CL	0	0	0	0	42
MFSD4A	9	0	13	0	146
MGARP	1	14	2	0	115
NAGK	1	9	3	0	18
NCCRP1	0	1	1	0	28
PLBD1	0	0	0	0	34
PPL	3	31	8	0	23
PRSS8	0	1	0	0	31
RAB5A	12	20	61	0	20
RAMP3	0	7	0	0	100
RNASE7	0	1	0	0	15
S100A2	1	13	4	0	21
S100A7A	0	1	0	0	26
SDR16C5	0	9	0	0	9
SDR9C7	0	0	0	0	22
SERPINB2	0	0	5	0	24
SERPINB3	1	1	4	1	32
SERPINB4	2	3	4	0	36
SLC25A4	2	3	12	0	40
SLC25A5	1	1	36	2	2
TGM1	0	24	1	0	35
TNFSF8	0	2	0	0	80
TYMP	0	2	0	0	22
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METABOLIC SUMMARYⁱ In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as the number of reactions for the selected gene. By clicking on a pathway in the summary table the associated metabolic network map is shown, together with a gene-tissue heatmap that shows the expression of genes in that pathway in different tissues.
Gene SLC25A6 is associated with 1 reactions in 1 different subsystems, and present in the compartments: Cytosol, Mitochondria. Provided by metabolicatlas.org
Pathway / Subsystem	Subsystem-associated compartments	# proteins	# metabolites	# reactions for this protein
Transport reactions	Cytosol, Extracellular, Lysosome, Peroxisome, Mitochondria, Golgi apparatus, Endoplasmic reticulum, Nucleus, Inner mitochondria	563	1599	1

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Splice variant	SwissProt	TrEMBL	Protein class	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC25A6-201	P12236	Q6I9V5	Metabolic proteins Transporters Predicted membrane proteins Plasma proteins FDA approved drug targets Mapped to neXtProt Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	298 aa 32.9 kDa	No	3