Brain tissue expression of ELN in pons - The Human Protein Atlas

PONS - Expression summary

Protein expressionⁱ

No data

RNA expressionⁱ

HPA Brain:	238.9	nTPM
FANTOM5:	9.1	Scaled Tags Per Million

Macaque:	7.5	nTPM
Mouse:	4.1	nTPM
Rat:	8.8	nTPM
Pig:	5.1	nTPM

PONS - SINGLE NUCLEI RNA EXPRESSIONⁱ RNA expression in the single nuclei cluster types identified in this brain region visualized by a UMAP plot (top) and a bar chart (to the right). - UMAP PLOT visualizes the cells in each cluster; where each dot corresponds to a cell. For each individual cell, mouseover reveals read count and which cluster the cell belongs to. Hovering over a cluster name will highlight the corresponding cluster in the bar chart two the right. There are 2 options for color schemes: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster. There are 3 options for cell intensities: 1) Intensity, which color the individual cells according to % of max (log2(read_count+1)/log2(max(read_count)+1)100) in five different bins (<1%,<25%,<50%,<75%,≥75%) 2) Interval, which color the individual cells according to fixed interval of read count (0,1,2-4,5-9,>10) 3) Hexagon, which color the hexagon on average read count of all cells inside the hexagon - The BAR CHART* shows RNA expression (nTPM) in each cluster type. Hovering over the cluster name reveals nTPM value and number of included cells. Hovering over a bar highlights the corresponding cluster in the UMAP plot above. Color-coding can be toggled on the top of the page, between 2 options: 1) cell type color, which is based on cell type groups used in the Single cell type part of the Single cell resource and 2) cluster color, which assigns a unique color to each cluster.

SINGLE NUCLEI BRAIN - PONS, NEURONSⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Excitatory (VGLUT1/2)
	c-2	Excitatory (VGLUT1) ETV1+ Z...
	c-3	Excitatory (VGLUT1/2)
	c-4	Excitatory (VGLUT1) ETV1+ Z...
	c-5	Excitatory (VGLUT1/2)
	c-6	Excitatory (VGLUT1/2)
	c-7	Excitatory (VGLUT1/2)
	c-8	Inhibitory (GAD1/2) SLC6A5+
	c-9	Excitatory (VGLUT2)
	c-10	Excitatory (VGLUT1/2)
	c-11	Excitatory (VGLUT1/2)
	c-12	Unassigned
	c-13	Inhibitory (GAD1/2) RORB+ K
	c-14	Inhibitory (GAD1/2) SST+
	c-15	Excitatory (VGLUT1) ETV1+ Z...
	c-16	Excitatory (VGLUT2)
	c-17	Excitatory (VGLUT1/2)
	c-18	Inhibitory (GAD1/2)
	c-19	Inhibitory (GAD1) PENK+ SST
	c-20	Excitatory (VGLUT2) FOXP2+
	c-21	Excitatory (VGLUT2) LMX1A+
	c-22	Excitatory (VGLUT2) MEIS2+
	c-23	Inhibitory (GAD1/2) SLC6A5+...
	c-24	Inhibitory (GAD1/2) SLC6A5+...
	c-25	Serotonergic SLC6A4+ SLC18A...
	c-26	Inhibitory (GAD1/2) PVALB+ ...
	c-27	Excitatory (VGLUT2)
	c-28	(VGLUT3) PENK+
	c-29	MEIS2+
	c-30	LMX1A+
	c-31	Inhibitory (GAD1/2) TAC1+
	c-32	Excitatory (VGLUT2) PVALB+
	c-33	Inhibitory (GAD1/2) PVALB+ ...
	c-34	Inhibitory (GAD1/2)
	c-35	Excitatory (VGLUT2) SST+ ME...
	c-36	LC Noradrenergic SLC6A2+ SL...
	c-37	Excitatory (VGLUT2) CRH+ FO...
	c-38	Inhibitory (GAD1/2) PVALB+ ...
	c-39	Excitatory (VGLUT2)
	c-40	Excitatory (VGLUT2) PVALB+
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

SINGLE NUCLEI BRAIN - PONS, NON-NEURONALⁱ

Cell type color

Cluster color

Colored according to cell type group

Read count filter: 0

Cluster		Cell type
	c-1	Oligodendrocytes
	c-2	Oligodendrocytes
	c-3	Oligodendrocyte progenitor ...
	c-4	Oligodendrocytes
	c-5	Oligodendrocytes
	c-6	Oligodendrocytes
	c-7	Microglia
	c-8	Astrocytes
	c-9	Oligodendrocytes
	c-10	Astrocytes (CD44+)
	c-11	Oligodendrocytes
	c-12	Fibroblasts
	c-13	Vascular endothelial cells
	c-14	Pericytes
	c-15	Ependymal cells
	c-16	Lymphocytes
	c-17	Macrophages
	c-18	Microglia (SPP1+ HIF1A+)
	c-19	Bergmann glia
	c-20	Immature oligodendrocytes
	c-21	Oligodendrocyte progenitor ...
	c-22	Vascular smooth muscle cell
	c-23	Monocytes
	c-24	Immature oligodendrocytes
	c-25	Fibroblasts (BNC2+ KCNMA1+ ...
	c-26	Choroid plexus epithelial c...
	c-27	Macrophage Microglia double
	c-28	OPC & lymphocytes doublets
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This data was generated by Siletti K et al. (2023), re-processed by HPA (see methods) and simplified for global overview

PONS - HPA Brain Stereo-seq

PONS - HPA Brain RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	238.9

Sample id

Sample description

nTPM

Anterior cochlear nucleus, ventral
nTPM: 201.5

2301	Female, age 85, both hemispheres	242.1
2188	Female, age 91, both hemispheres	234.3
2090	Male, age 80, both hemispheres	231.9
1984	Male, age 76, both hemispheres	97.6

Dorsal cochlear nucleus
nTPM: 172.3

2378	Male, age 80, both hemispheres	219.5
2802	Male, age 74, right hemisphere	193.3
2370	Male, age 61, both hemispheres	174.3
2187	Female, age 91, both hemispheres	162.3
2058	Male, age 76, both hemispheres	112.0

Dorsal tegmental nucleus
nTPM: 174.3

2083	Male, age 80, both hemispheres	214.1
2358	Male, age 61, both hemispheres	204.2
2326	Male, age 74, both hemispheres	153.6
1936	Male, age 76, left hemisphere	125.2

Dorsolateral tegmental area
nTPM: 181.0

2654	Male, age 80, both hemispheres	244.7
2751	Female, age 85, both hemispheres	229.7
2337	Male, age 61, both hemispheres	201.8
2141	Male, age 76, both hemispheres	128.3
2360	Male, age 74, both hemispheres	100.7

Kolliker-Fuse nucleus
nTPM: 186.2

2793	Female, age 91, left hemisphere	286.5
2163	Male, age 80, both hemispheres	177.8
2315	Male, age 76, right hemisphere	94.4

Lateral lemniscal nuclei
nTPM: 213.7

2320	Female, age 91, left hemisphere	283.7
2036	Male, age 80, both hemispheres	209.0
2746	Female, age 85, left hemisphere	204.9
2453	Male, age 74, right hemisphere	200.1
2169	Male, age 76, both hemispheres	170.7

Lateral parabrachial nucleus
nTPM: 188.2

2792	Male, age 76, both hemispheres	266.1
2013	Male, age 80, both hemispheres	203.0
2790	Male, age 61, both hemispheres	147.2
2139	Female, age 85, right hemisphere	136.4

Lateral vestibular nucleus
nTPM: 202.8

2184	Male, age 76, both hemispheres	233.2
2311	Male, age 80, both hemispheres	172.3

Locus coeruleus
nTPM: 81.8

2720	Male, age 74, both hemispheres	117.4
2162	Male, age 80, both hemispheres	94.6
2123	Female, age 91, both hemispheres	79.5
2317	Female, age 72, unknown	78.8
2788	Male, age 74, unknown	70.5
1980	Male, age 76, both hemispheres	66.7
2014	Male, age 55, unknown	65.2

Medial parabrachial nucleus
nTPM: 191.6

2786	Male, age 76, both hemispheres	247.1
2156	Male, age 61, both hemispheres	199.4
2854	Male, age 80, both hemispheres	185.0
2170	Female, age 91, both hemispheres	166.8
2463	Female, age 85, right hemisphere	159.8

Medial periolivary nuclei
nTPM: 193.0

2081	Male, age 80, both hemispheres	320.5
2458	Female, age 91, both hemispheres	268.5
2171	Female, age 85, both hemispheres	153.1
2791	Male, age 74, right hemisphere	141.3
2063	Male, age 76, both hemispheres	81.5

Motor facial nucleus
nTPM: 183.8

2697	Female, age 85, both hemispheres	303.9
2126	Male, age 61, both hemispheres	214.6
2795	Female, age 91, both hemispheres	182.6
2327	Male, age 80, both hemispheres	176.0
2365	Male, age 74, right hemisphere	147.1
2062	Male, age 76, both hemispheres	78.6

Motor trigeminal nucleus
nTPM: 211.6

2309	Male, age 76, both hemispheres	256.2
2321	Female, age 91, both hemispheres	241.5
2560	Male, age 74, both hemispheres	197.8
2079	Male, age 80, both hemispheres	189.9
2335	Male, age 61, both hemispheres	172.7

Nuclei of the trapezoid body
nTPM: 150.9

2166	Male, age 80, both hemispheres	249.1
2159	Male, age 61, both hemispheres	176.6
2368	Female, age 91, both hemispheres	167.6
1983	Male, age 76, both hemispheres	81.0
2735	Female, age 85, both hemispheres	80.2

Nucleus raphe magnus
nTPM: 153.3

2459	Female, age 91, both hemispheres	251.8
2328	Male, age 80, both hemispheres	203.2
2051	Male, age 76, both hemispheres	187.1
2455	Male, age 74, both hemispheres	133.3
2172	Female, age 85, both hemispheres	87.8
2160	Male, age 61, both hemispheres	56.3

Paramedian reticular nucleus
nTPM: 182.6

2052	Male, age 76, both hemispheres	270.4
2057	Male, age 80, both hemispheres	193.4
2050	Female, age 85, both hemispheres	178.9
2313	Male, age 61, both hemispheres	87.5

Pedunculopontine tegmental nucleus
nTPM: 157.6

2338	Male, age 61, both hemispheres	229.8
2334	Male, age 80, both hemispheres	150.0
1921	Female, age 85, both hemispheres	93.0

Pontine nuclei
nTPM: 191.3

2319	Female, age 91, both hemispheres	314.3
2115	Male, age 80, left hemisphere	279.5
2454	Male, age 74, left hemisphere	194.6
1863	Male, age 55, unknown	178.7
1968	Male, age 76, left hemisphere	177.8
2787	Female, age 85, both hemispheres	151.5
2727	Male, age 61, right hemisphere	128.2
2109	Female, age 72, unknown	106.0

Pontine raphe nucleus
nTPM: 135.5

2853	Male, age 76, midline	142.8
2122	Female, age 85, midline	128.2

Posteroventral cochlear nucleus
nTPM: 203.0

2135	Female, age 91, both hemispheres	271.8
2070	Male, age 76, both hemispheres	256.5
2341	Male, age 80, both hemispheres	251.0
2371	Male, age 61, both hemispheres	133.8
2752	Female, age 85, both hemispheres	101.7

Principal sensory trigeminal nucleus
nTPM: 194.6

2367	Female, age 91, left hemisphere	327.6
2008	Male, age 80, left hemisphere	187.5
2324	Male, age 76, both hemispheres	152.0
2158	Male, age 61, both hemispheres	111.5

Reticular pontine nucleus, caudal
nTPM: 238.9

2457	Female, age 91, both hemispheres	334.5
2332	Male, age 80, right hemisphere	235.2
2559	Male, age 74, both hemispheres	201.5
2092	Male, age 76, both hemispheres	184.4

Reticular pontine nucleus, oral
nTPM: 219.5

2366	Female, age 91, both hemispheres	273.9
2361	Male, age 74, both hemispheres	222.3
2012	Female, age 85, both hemispheres	217.1
2167	Male, age 76, both hemispheres	207.2
1939	Male, age 80, both hemispheres	177.1

Reticulotegmental nucleus
nTPM: 193.5

2333	Male, age 80, both hemispheres	222.8
2322	Female, age 91, both hemispheres	205.4
2452	Male, age 74, both hemispheres	202.3
2325	Male, age 76, both hemispheres	143.5

Spinal trigeminal nucleus, oral
nTPM: 163.9

2164	Male, age 80, both hemispheres	243.4
2737	Female, age 85, both hemispheres	139.6
1978	Male, age 76, both hemispheres	108.6

Subcoeruleus area
nTPM: 184.5

2369	Female, age 85, left hemisphere	309.9
2089	Male, age 76, left hemisphere	208.5
2451	Male, age 74, both hemispheres	153.5
1958	Male, age 80, both hemispheres	131.4
2323	Female, age 91, left hemisphere	119.2

Superior olive
nTPM: 200.1

2329	Male, age 80, right hemisphere	280.2
2561	Female, age 91, both hemispheres	273.1
1875	Female, age 85, both hemispheres	186.8
2020	Male, age 76, both hemispheres	170.2
2364	Male, age 74, right hemisphere	90.0

Ventral periolivary nuclei
nTPM: 190.3

2794	Female, age 91, left hemisphere	230.0
2023	Male, age 76, both hemispheres	228.9
2165	Male, age 80, both hemispheres	159.8
2130	Female, age 85, both hemispheres	142.3

Ventrolateral tegmental area, A5 NE cell group
nTPM: 184.5

2456	Female, age 91, both hemispheres	288.6
2840	Female, age 85, both hemispheres	232.7
2161	Male, age 80, both hemispheres	210.4
2359	Male, age 61, both hemispheres	132.3
2449	Male, age 74, both hemispheres	130.8
1959	Male, age 76, both hemispheres	112.1

PONS - FANTOM5 CAGEⁱ

Max subtype Scaled Tags Per Millionⁱ Max subtype Scaled Tags Per Million is the value for the subtype with the largest average Scaled Tags Per Million across the subtype samples.	9.1

FANTOM5 sample id

Sample description

Scaled Tags Per Million

Locus coeruleus
Scaled Tags Per Million: 9.1

FF:10165-103B3	76 years, female	9.6
FF:10182-103D2	60 years, female	8.7

Pons
Scaled Tags Per Million: 7.3

FF:10033-101E6

18-54 years, mixed

7.3

PONS - Macaque RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	7.5

Macaque sample

Sample description

nTPM

Pons
nTPM: 7.6

Samples: 2

Max nTPM: 10.4
Min nTPM: 4.7

Sample A		4.7
Sample B		10.4

PONS - Pig RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	5.1

Pig sample

Sample description

nTPM

Pons
nTPM: 5.1

Samples: 3

Max nTPM: 12.9
Min nTPM: 1.2

Sample A	Female	12.9
Sample B	Female	1.3
Sample C	Male	1.2

PONS - Mouse RNA-seqⁱ

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	4.1

Mouse sample

Sample description

nTPM

Pons
nTPM: 4.1

Samples: 4

Max nTPM: 4.9
Min nTPM: 3.5

Sample A		4.9
Sample B		3.9
Sample C		4.0
Sample D		3.5

PONS - Rat RNA-seq

Max subtype nTPMⁱ Max subtype nTPM is the value for the subtype with the largest average nTPM across the subtype samples.	8.8

Rat sample

Sample description

nTPM

Pons
nTPM: 8.9

Samples: 4

Max nTPM: 11.5
Min nTPM: 7.6

Sample A		7.8
Sample A		7.6
Sample A		11.5
Sample A		8.5